Relationship between cadmium content in semen and male infertility: a meta-analysis
- 63 Downloads
Meta-analysis with high-quality studies can provide superior evidence. In this paper, we use meta-analysis to analyze the relationship between cadmium (Cd) content in semen and male infertility, and then objectively evaluate the effect of Cd on sperm quality. The objectives of this study were to update our understanding of infertility and to provide evidence to treat and prevent the infertility. We searched potentially relevant studies that were published from establishing database data to April 2018. Articles came from the databases of CNKI, Wanfang, VIP, PubMed, CMCI, and EMBASE. A total of 11 articles were included. We gathered the mean and variance of the infertility group and the control group to compare the Cd content in two groups. In total, the 11 studies include 1707 subjects, 1093 of which were in the infertility group and 614 of which were in the control group. We can get some information from this meta-analysis: SMD = 0.50 (95% Cl 0.39–0.61), Z = 8.92, P < 0.05; the funnel plot of the meta-analysis shows incomplete symmetry, which may have the publication bias. Therefore, the high content of Cd in semen is a causative factor of infertility. The Cd content in semen can be used as an indicator of sperm quality.
KeywordsInfertility Cadmium Meta-analysis Semen
The authors thank Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine.
This study was supported by the National Natural Science Foundation of China (Grant No. 31472161).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflicts of interest.
- Chen T et al. (2009) Correlation of trace elements with male infertility. Chin J Health Lab Technol 155–156Google Scholar
- Frühmesser A, Vogt PH, Zimmer J, Witsch-Baumgartner M, Fauth C, Zschocke J, Pinggera GM, Kotzot D (2013) Single nucleotide polymorphism array analysis in men with idiopathic azoospermia or oligoasthenozoospermia syndrome. Fertil Steril 100:81–87. https://doi.org/10.1016/j.fertnstert.2013.03.016 CrossRefGoogle Scholar
- Keck C, Bramkamp G, Behre HM, Müller C, Jockenhövel F, Nieschlag E (1995) Lack of correlation between cadmium in seminal plasma and fertility status of nonexposed individuals and two cadmium-exposed patients. Reprod Toxicol 9(35):35–40. https://doi.org/10.1016/0890-6238(94)00053-Y CrossRefGoogle Scholar
- Li X, Xing M, Chen M, Zhao J, Fan R, Zhao X, Cao C, Yang J, Zhang Z, Xu S (2017) Effects of selenium-lead interaction on the gene expression of inflammatory factors and selenoproteins in chicken neutrophils. Ecotoxicol Environ Saf 139:447–453. https://doi.org/10.1016/j.ecoenv.2017.02.017 CrossRefGoogle Scholar
- Liu J (1986) Studies in technic of cryopreservation for human spermatozoa by liquid nitrogen vapor——I. Effects on sperm survival rate of different methods of storage and different times of cold—balance. doi: https://doi.org/10.13361/j.qdyxy.1986.04.003
- Meerpohl JJ, Timmer A, Antes G (2008) Evidence-based medicine and systematic reviews. Mmw Fortschr Med 150:41–43. https://doi.org/10.1007/BF03365424
- Mendiola J, Moreno JM, Roca M, Vergara-Juárez N, Martínez-García MJ, García-Sánchez A, Elvira-Rendueles B, Moreno-Grau S, López-Espín JJ, ten J, Bernabeu R, Torres-Cantero AM (2011) Relationships between heavy metal concentrations in three different body fluids and male reproductive parameters: a pilot study. Environ Health 10:6. https://doi.org/10.1186/1476-069X-10-6 CrossRefGoogle Scholar
- Salort-Llorca C, Mínguez-Serra MP, Silvestre FJ (2008) Drug-induced burning mouth syndrome: a new etiological diagnosis. Med Oral Patol Oral Cir Bucal 13:E167–E170Google Scholar
- Semczuk M, Semczuksikora A (2001) New data on toxic metal intoxication (Cd, Pb, and Hg in particular) and Mg status during pregnancy. Med Sci Monit 7:332–340Google Scholar
- Shaoxian L et al. (1994) Determination of eight elements in semen of infertile patients and normal persons and analysis of zinc to cadmium ratio. J Reprod Med 84–86Google Scholar
- Wittmaack FM, Shapiro SS (1992) Longitudinal study of semen quality in Wisconsin men over one decade. Wis Med J 91:477Google Scholar
- Xiaojia W, Ziming H, Chunli L (1995) Analysis of trace elements zinc, copper, lead and cadmium in human semen. Reprod Contracept 393–395Google Scholar
- Xu Z (2012) Detection and analysis of trace elements of seminal plasma in male infertility. Hainan Med J. https://doi.org/10.3969/j.issn.1003-6350.2012.03.039
- Zheng L, Zhu X, Qin J, Ma N, Luo K (2012) Correlation between sperm quality and trace elements in infertile patients international. J Lab Med 33:659–660. https://doi.org/10.3969/j.issn.1673-4130.2012.06.009 Google Scholar