Enantioselective degradation of the chiral alpha-cypermethrin and detection of its metabolites in five plants
- 67 Downloads
Alpha-cypermethrin (α-cypermethrin), an important chiral pyrethroid insecticide, is frequently detected in human samples. Because of the possible human health risks caused by α-cypermethrin, we studied dynamics, residues, and metabolism of α-cypermethrin in five common vegetables (tomato, cucumber, rape, cabbage, and pepper) on enantiomeric levels after foliar spray. α-Cypermethrin was qualified by a HP-5 column and its enantiomers could be separated by gas chromatograph (GC) using a BGB-172 chiral column. The results of degradation showed that α-cypermethrin dissipated rapidly in vegetables with half-lives being only 2.85–8.88 days. Stereoselective degradation was observed on pepper and cucumber while the two metabolites (cis-DCCA and 3-PBA) of α-cypermethrin were not detected during its dissipation in all plants. This is the first evidence of enantioselective degradation of α-cypermethrin in the five common vegetables and the results should be considered in future environmental risk and food safety evaluations.
KeywordsEnantioselective Degradation Metabolites Alpha-cypermethrin Plants
This work was supported by the National Natural Science Foundation of China (Contract Grants: 21337005).
- Barr DB, Olsson AO, Wong LY, Udunka S, Baker SE, Whitehead RD, Magsumbol MS, Williams BL, Needham LL (2010) Urinary concentrations of metabolites of pyrethroid insecticides in the general U.S. population: national health and nutrition examination survey 1999–2002. Environ Health Perspect 118:742–748CrossRefGoogle Scholar
- Hardt J, Angerer J (2003) Biological monitoring of workers after the application of insecticidal pyrethroids. Int Arch Occup Environ Health 76:492–498Google Scholar
- Jin Y, Zhang P, Wang X, Xu M, Wang Y, Zhou Z, Zhu W (2015) Stereoselective degradation of alpha-Cypermethrin and its enantiomers in rat liver microsomes. Chirality 28:58–64Google Scholar
- Knaak JB, Dary CC, Zhang X, Gerlach RW, Tornero-Velez R, Chang DT, Goldsmith R, Blancato JN (2012): Parameters for pyrethroid insecticide QSAR and PBPK/PD models for human risk assessment. Springer New York, 1–114 ppGoogle Scholar
- Naeher LP, Tulve NS, Egeghy PP, Barr DB, Adetona O, Fortmann RC, Needham LL, Bozeman E, Hilliard A, Sheldon LS (2010) Organophosphorus and pyrethroid insecticide urinary metabolite concentrations in young children living in a southeastern United States city. Sci Total Environ 408:1145–1153CrossRefGoogle Scholar
- Velisek J, Wlasow T, Gomulka P, Svobodova Z, Dobsikova R, Novotny L, Dudzik M (2006): Effects of cypermethrin on rainbow trout (Oncorhynchus mykiss). Veterinarni Medicina - UZPI (Czech Republic) 51: 469Google Scholar
- Worthing CR, Walker SB (1983) The pesticide manual, a world compendium. British Crop Protection CouncilGoogle Scholar