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Environmental Science and Pollution Research

, Volume 25, Issue 35, pp 35501–35514 | Cite as

Effects of single exposure and binary mixtures of ultraviolet filters octocrylene and 2-ethylhexyl 4-(dimethylamino) benzoate on gene expression in the freshwater insect Chironomus riparius

  • Ana-Belén Muñiz-González
  • José-Luis Martínez-GuitarteEmail author
Research Article

Abstract

Ultraviolet filters are used extensively in the production of many personal care and industrial products. These products can inadvertently pollute the environment through recreational activities. They have been associated with endocrine disruption in vertebrates but their effects in invertebrates are poorly understood. Chironomus riparius is a species of the dipteran order, with aquatic larvae that are frequently used in toxicity tests. Previously, we showed that octocrylene (OC) and 2-ethylhexyl 4-(dimethylamino) benzoate (OD-PABA) differentially affected the mRNA levels of the ecdysone receptor and Hsp70 genes. For a better understanding of their mode of action, transcriptional activity by real-time PCR was analyzed in fourth instar larvae exposed to OC, OD-PABA, or a binary mixture of both. We studied 16 genes related to the endocrine system, stress, the immune system, and biotransformation mechanisms to elucidate the putative interactions between these compounds. No response was observed for the genes involved in biotransformation, suggesting that enzymes other than cytochromes P450 and glutathione-S-transferases (GSTs) could get involved in transformation of these compounds. Similarly, no response was observed for endocrine-related genes while the stress gene HYOU1 was inhibited by OD-PABA, suggesting an effect in response to hypoxia. In addition, no significant interactions were observed following exposure to a binary mixture of these compounds. Overall, the results suggest a weak, acute response in different metabolic pathways and a lack of interaction between the compounds. Finally, new genes are identified in this organism, opening the possibility to analyze new cellular pathways as targets of toxicants.

Keywords

UV filters Binary mixture Endocrine system Stress Biotransformation Invertebrate Endocrine disruptors Chironomus riparius 

Notes

Funding information

This work was supported by Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica (Spain), grant CTM2015-64913-R from the Ciencias y Tecnologías Medioambientales program. A.B.M.G is the receiver of a predoctoral contract from Universidad Nacional de Educación a Distancia.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.

Supplementary material

11356_2018_3516_MOESM1_ESM.pdf (552 kb)
ESM 1 (PDF 551 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Grupo de Biología y Toxicología Ambiental, Departamento de Física Matemática y de FluidosUniversidad Nacional de Educación a Distancia, UNEDMadridSpain
  2. 2.Facultad de CienciasUNEDMadridSpain

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