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Tobacco influence in heavy metals levels in head and neck cancer cases

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Abstract

Heavy metals intoxication is known to be risk factors for various diseases, including cancer. These metals may be presented in food and soil as well as in leaf and tobacco smoke. The aim of this study was to correlate the exposure to heavy metals stemming from tobacco and head and neck squamous cell carcinoma carcinogenesis. Analysis of lead, copper, manganese, arsenic, chromium, and cadmium by atomic absorption spectrophotometry was performed in whole blood samples from 91 patients: 68 smokers with oral cavity, pharynx, or laryngeal cancer; 8 non-smokers with oral or larynx cancer; and 15 non-cancer smokers with tobacco-related diseases (control group). No differences were found in metals quantifications, except a significant difference was observed (p = 0.0223) with higher mean in copper levels for non-smokers with cancer. The present study concluded, for the groups evaluated, it was not possible to prove the relationship between the studied metals in the development of the neoplasm. On the other hand, the results of copper demonstrated a correlation with smokers with cancer and lower levels of circulating copper.

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Acknowledgments

The authors thank the Center of Toxicological Assistance (CEATOX), São Paulo State University (Unesp), Institute of Biosciences of Botucatu, Botucatu, São Paulo, Brazil.

Author information

Correspondence to Janete Dias Almeida.

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The present work was approved by the ethics committee of ISCMSP (Protocol number 147/10) and complies with the international guidelines of human use on sciences. All the participants agreed to participate in the research and signed an Informed Consent Term (ICT).

Conflict of interest

The authors declare that they have no competing interests.

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Responsible editor: Philippe Garrigues

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Cite this article

Bandeira, C.M., de Almeida, A.Á., Carta, C.F.L. et al. Tobacco influence in heavy metals levels in head and neck cancer cases. Environ Sci Pollut Res 25, 27650–27656 (2018). https://doi.org/10.1007/s11356-018-2668-9

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Keywords

  • Tobacco
  • Carcinoma, squamous cell
  • Head and neck neoplasms
  • Metals, heavy