Advertisement

Environmental Science and Pollution Research

, Volume 25, Issue 26, pp 26446–26460 | Cite as

New applied pharmacological approach/trend on utilization of agro-industrial wastes

  • Tamer I. M. Ragab
  • Al Shimaa Gamal Shalaby
  • Sally A. El Awdan
  • Ahmed Refaat
  • Wafaa A. Helmy
Research Article
  • 57 Downloads

Abstract

This study aimed to transform the locally available lignocellulosic residual palm frond (PF) and rice straw (RS) wastes into multifunction added products like methylated cellulose and sulfated and phosphorylated hemicelluloses by simple processes. Hydrolysis with 2 N sulfuric acid was the most suitable reaction for microcrystalline cellulose production. The characteristics of the prepared products were studied to obtain the optimum reaction conditions. Palm frond hemicellulose (PFHC) recorded the highest antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Candida albicans (22, 22, 26 mm), respectively, and phosphorylated palm frond hemicellulose (PPFHC) exhibited the highest potential antioxidant activity of approximately 60%, suggesting a possible correlation between the two bioactivities. Most of extracted celluloses and their derivatives had a variety of promising probiotic activities which are expected to reduce the side effects of the gastric mucosa and possibly play a role in curing the gastric ulcer. Accordingly, the determination of anti-inflammatory and gastroprotective activity results revealed that methylcellulose, sulfated and phosphorylated hemicelluloses showed anti-inflammatory and gastroprotective activities and the capability of all tested compounds to ameliorate the ethanol-induced gastric ulcer in rats’ stomach. All results recommended PF and RS and their derivatives to be used as a medicinal food.

Keywords

Microcrystalline cellulose Sulfated and phosphorylated hemicelluloses Methylcellulose Gastroprotective Gastric ulcer and carrageenan 

Notes

Funding information

The authors thank Prof. Dr. Mona Esawy Department of Chemistry of Natural and Microbial Products, Division of Pharmaceutical Industry, and National Research Center for supporting and funding this work.

Compliance with ethical standards

Animal procedures were performed in accordance with the Ethics Committee of the National Research Centre and followed the recommendations of the National Institutes of Health Guide for Care and Use of Laboratory Animals (NIH., 1985).

Conflict of interest

The authors declare that they have no conflict of interest.

References

  1. Abdel-Fattah AM, Gamal-Eldeenb AM, Helmy WA, Esawy MA (2012) Antitumor and antioxidant activities of Levan and its derivative from the isolate Bacillus subtilis NRC1aza. Carbohydr Polym 89:314–322.  https://doi.org/10.1016/j.carbpol.2012.02.041 CrossRefGoogle Scholar
  2. Abou Hussein SD, Sawan OM (2010) The utilization of agricultural waste as one of the environmental issues in Egypt (a case study). J Appl Sci Res 6:1116–1124Google Scholar
  3. American Public Health Association, American Chemical Society, (1920) Association of official agricultural chemists standard methods for the examination of water and sewage. American Public Health Association, p 95Google Scholar
  4. AssociaçãoBrasileiraTécnica de Celulose e Papel-ABTCP(1996) Standard C26-Pastacelulósica–Determinação de viscosidadeintrínsecaemsolução de cuproetilenodiamina (CUEN) com viscosímetrotipocapilaGoogle Scholar
  5. Brown LF, Wilson DE (1999) Gastroduodenal ulcers: causes, diagnosis, prevention and treatment. ComprTher 25(1):30–38Google Scholar
  6. Chattopadhyay D, Arunachalam G, Mandal AB, Sur TK, Mandal SC, Bhattacharya SK (2002) Antimicrobial and anti-inflammatory activity of folklore: Mallotus peltatus leaf extract. J Ethnopharmacol 82:229–237.  https://doi.org/10.1016/S0378-8741(02)00165-4 CrossRefGoogle Scholar
  7. Chandrasekaran B (2013) Valorization of date palm (Phoenix dactylifera) fruit processing by-products and wastes using bioprocess technology. Review 8:581–587.  https://doi.org/10.1016/j.sjbs.2012.12.004 Google Scholar
  8. De Man JD, Rogosa M, Sharpe ME (1960) A medium for the cultivation of lactobacilli. J Appl Bact 23:130–135.  https://doi.org/10.1111/j.1365-2672.1960.tb00188.x CrossRefGoogle Scholar
  9. Dace R, Mcbride E, Brooks K, Gander J, Buszko M, Doctor VM (1997) Comparison of the anticoagulant action of sulfated and phosphorylated polysaccharides. Thromb Res 87(1):113–121.  https://doi.org/10.1016/S0049-3848(97)00110-2 CrossRefGoogle Scholar
  10. Dave RH (2011) Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics. Advanstar.Google Scholar
  11. Dufresne A (2008) Polysaccharide nano crystal reinforced nanocomposites. Can J Chem 8(6):484–494.  https://doi.org/10.1139/v07-152 CrossRefGoogle Scholar
  12. El-Dakhakhny M, Barakat M, El-Halim MA, Aly SM (2000) Effects of Nigella sativa oil on gastric secretion and ethanol induced ulcer in rats. J Ethnopharmacol 72(1–2):299–304.  https://doi.org/10.1016/S0378-8741(00)00235-X CrossRefGoogle Scholar
  13. Erginer M, Ayca Akcay A, Binnaz C, Tunc M, Deniz R, Seyda B, Nihat B, Rahmi O, Mehmet SE, Mehmet A, Ebru TO (2016) Sulfated Levan from Halomonas smyrnensis as a bioactive, heparin-mimetic glycan for cardiac tissue engineering applications. Carbohydr Polym 149:289–296.  https://doi.org/10.1016/j.carbpol.2016.04.092 CrossRefGoogle Scholar
  14. Fengel D, Wegener G (1989) Wood—chemistry, ultrastructure, reactions, 2nd edn. Walter de Gruyter, Berlin.  https://doi.org/10.1002/pol.1985.130231112 Google Scholar
  15. Garrido ML (1964) Determination of sulphur in plant material. Analyst 89:61–66.  https://doi.org/10.1039/AN9648900061 CrossRefGoogle Scholar
  16. Ghimire KN, Inoue K, Yamaguchi H, Makino K, Miyajima T (2003) Adsorptive separation of arsenate and arsenite anions from aqueous medium by using orange waste. Water Res 37:4945–4953.  https://doi.org/10.1016/j.watres.2003.08.029 CrossRefGoogle Scholar
  17. Han JS, Rowell JS (1996) Chemical composition of fibers. In: Rowell RM, Young RA, Rowell J (eds) Paper and composites from agrobased resources. CRC, LondonGoogle Scholar
  18. Hassan EA, Hassan ML (2016) Rice straw nanofibrillated cellulose films with antimicrobial properties via supramolecular route. Ind Crop Prod 93:142–150.  https://doi.org/10.1016/j.indcrop.2016.02.025 CrossRefGoogle Scholar
  19. Hon DNS (1996) Cellulose and its derivatives. In: Dimitriu S (ed) Plysaccharides in medicinal applications. Marcel Dekker, New YorkGoogle Scholar
  20. Hwang ES, Do Thi N (2014) Effects of extraction and processing methods on antioxidant compound contents and radical scavenging activities of laver (Porphyratenera). Prev Nutr Food Sci 19:40–48.  https://doi.org/10.3746/pnf.2014.19.1.040 CrossRefGoogle Scholar
  21. Hussaini J, Nazmul MHM, Abdullah MA, Ismail S (2012) Recombinant clone ABA392 protects laboratory animals from Pasteurella multocida serotype B.J. Vet Adv 2(2):114–119Google Scholar
  22. Hussin N, Hazwan M, Aqilah P, Zaharaddeen N, Garba M, Jain K, Abdul Rahim A, Nicolas B, Mehdi Yemloul MR, NurulFazita MK, Mohamad H (2016) Physicochemical of microcrystalline cellulose from oil palm fronds as potential methylene blue adsorbents. Int J Biol Macromol 92:11–19.  https://doi.org/10.1016/j.ijbiomac.2016.06.094 CrossRefGoogle Scholar
  23. Hussein MM, Ghaly MF, ShalabyAlG OMY, Helal MM (2015) Production and prebiotic activity of exopolysaccharides derived from some probiotics.Egypt Pharm J 14:1–9.  https://doi.org/10.4103/1687-4315.154687 CrossRefGoogle Scholar
  24. Ibrahim MM, Ali HM, Abdullah MA, Hassandarvish P (2012) Acute toxicity and gastroprotective effect of the Schiff base ligand (1)H-indole-3-ethylene-5-nitrosalicylaldimine and its nickel (II) complex on ethanol induced gastric lesions in rats. Molecules 17:12449–12459.  https://doi.org/10.3390/molecules171012449 CrossRefGoogle Scholar
  25. Jain KS, Shah AK, Bariwal J, Shelke SM, Kale AP, Jagtap JR, Bhosale AV (2007) Recent advances in proton pump inhibitors and management of acid-peptic disorders. Bioorg Med Chem 15(3):1181–1205.  https://doi.org/10.1016/j.bmc.2006.07.068 CrossRefGoogle Scholar
  26. Jainu M, Devi CS (2006) Gastroprotective action of Cissus quadrangularis extract against NSAID induced gastric ulcer: role of pro inflammatory cytokines and oxidative damage. Chem Biol Interact 161:262–270.  https://doi.org/10.1016/j.cbi.2006.04.011 CrossRefGoogle Scholar
  27. Khandanlou R, Ahmad MB, Shameli K, Saki E, Kalantari K (2014) Studies on properties of rice straw/polymer nanocomposites based on polycaprolactone and Fe3O4 nanoparticles and evaluation of antibacterial activity. Int J Mol Sci 15(10):18466–18483.  https://doi.org/10.3390/ijms151018466 CrossRefGoogle Scholar
  28. Khiari R, Mhenni MF, Belgacem MN, Mauret E (2010) Chemical composition and pulping of date palm rachis and Posidonia oceanica—a comparison with other wood and non-wood fibre sources. Bioresour Technol 101:775–780.  https://doi.org/10.1016/j.biortech.2009.08.079 CrossRefGoogle Scholar
  29. Kurosaki T, Furugaki H, Matsunaga A, Yuzawa M, Manba A (1990) Studies on phosphorylation. I. Phosphorylation of alcohol with phosphorus pentoxide in the presence of water. J Japan Oil ChemSoc 39:250–258.  https://doi.org/10.1021/ja01186a033 CrossRefGoogle Scholar
  30. Larsen B, Haug A, Painter JTJ (1960) Sulphated polysaccharides in brown algae 1- isolation and preliminary characterization of three sulphated polysaccharides of from Ascophyllum nodosum. Acta Chem Scand 20:219–230.  https://doi.org/10.3891/acta.chem.scand.24-3339 CrossRefGoogle Scholar
  31. Larsson PT, Wickholm K, Iversen T (1997) A CP/MAS C-13 NMR investigation of molecular ordering in celluloses. Carbohydr Res 302:19–25CrossRefGoogle Scholar
  32. Lora M, Morisset S, Menard HA, Leduc R, de Brum-Fernandes AJ (1997) Expression of recombinant human cyclooxygenase isoenzymes in transfected COS-7 cells in vitro and inhibition by tenoxicam, indomethacin and aspirin. Prostaglandins Leukot Essent Fatty Acids 56:361–367.  https://doi.org/10.1016/S0952-3278(97)90584-6 CrossRefGoogle Scholar
  33. Lima MM, Borsali R (2004) Rodlike cellulose microcrystals: structure, properties and applications. Macromol Rapid Commun 25:771–787.  https://doi.org/10.1002/marc.200300268 CrossRefGoogle Scholar
  34. Liu J, Luo J, Hong Y, Xiaoxiong Z (2012) Preparation, antioxidant and antitumor activities in vitro of different derivatives of Levan from endophytic bacterium Paenibacillus Polymyxa EJS-3. Food Chem Toxicol 50:767–772.  https://doi.org/10.1016/j.fct.2011.11.016 CrossRefGoogle Scholar
  35. McColl KE (2010) Clinical practice. Helicobacter pylori infection. N Engl J Med 362(17):1597–1604.  https://doi.org/10.1056/NEJMcp1001110 CrossRefGoogle Scholar
  36. Mohtar SS, Tengku NZT, Ahmad MMN, Norsalliana SHM (2017) An ionic liquid treatment and fractionation of cellulose, hemicellulose and lignin from oil palm empty fruit bunch. Carbohydrate Polymers 166:291–299.  https://doi.org/10.1016/j.carbpol.2017.02.102 CrossRefGoogle Scholar
  37. Mitscher LA, Leu RP, Bathala W, Beal JL (1972) Antimicrobial agents from higher plants. I. Introduction, rationale, and methodology. Lloydia 35:157–166Google Scholar
  38. Mohamed SS, EL-Desouky TA, Sherif RM, Khayria MNA, Mustafa HH (2015) Antioxidant compounds from rice straw extract and their effect on diazinon insecticide hazard. Middle East J Appl Sci 5(3):687–694Google Scholar
  39. Mohan R, Mukherjee A, Sevgen SE, Sanpitakseree C, Lee J, Schroeder CM, Kenis PJ (2013) A multiplexed microfluidic platform for rapid antibiotic susceptibility testing. Biosens Bioelectron 149:118–125CrossRefGoogle Scholar
  40. Mahmood S, Hassan S, Ahmed F, Ashraf M, Alam M, Muzaffar A (2005) Influence of feed withdrawal for different durations on performance of broilers in summer. Int J AgriBiol 7:975–978Google Scholar
  41. Mozsik G, Moron F, Javor T (1982) Cellular mechanisms of the development of gastric mucosal damage and of gastrocytoprotection induced by prostacyclin in rats. A pharmacological study. Prostaglandins Leukotrienes Med 9:71–84.  https://doi.org/10.1016/0262-1746(82)90074-9 CrossRefGoogle Scholar
  42. Myron R, Chellappan S, Sudhakar Y (2017) Report on the first international conference on cancer research and targeted therapy (CRT-2016). J Nat Prod Cancer Prev Ther 1(1):1–2Google Scholar
  43. Nuessle AC, Ford FM, Hall WP, Lippert AL (1956) Some aspects of the cellulose-phosphate-urea reaction. Text Res J 26(1):32–39CrossRefGoogle Scholar
  44. Panda SS, Chowdary PVR (2008) Synthesis of novel indolyl–pyrimidine A anti-inflammatory, antioxidant and antibacterial agents. Indian J Pharm Sci 70:208–215.  https://doi.org/10.4103/0250-474X.41457 CrossRefGoogle Scholar
  45. Paralikar KM, Aravindanath S (1988) Crystallization of cellulose. J Appl Polym Sci 35(8):2085–2089.  https://doi.org/10.1002/app.1988.070350809 CrossRefGoogle Scholar
  46. Pepeljnjak S, Kalodera Z, Zovko M (2005) Investigation of antimicrobial activity of Pelargonium radula (Cav.) L’Hérit. Acta Pharma 55:409–415Google Scholar
  47. Rafael L, Oliveira JG, Vieira HS, Barud R, Assunção MN, Guimes R, Sidney F, Ribeiro JL, Younes M (2015) Synthesis and characterization of methylcellulose produced from bacterial cellulose under heterogeneous condition. J Braz Chem Soc 26(9):1861–1870.  https://doi.org/10.5935/0103-5053.20150163 Google Scholar
  48. Ragab TIM, Amer H, Wasfy AAF, Abdel Hady MS, Abdel Tawab H, Liebner F (2014) Sulfated cellulose from agriculture wastes, anticoagulant, fibrinolytic and toxicological studies. J Environ Sci Technol 7(5):266–280.  https://doi.org/10.3923/jest.2014.266.280 CrossRefGoogle Scholar
  49. Robert A, Nezamis JE, Lancaster C, Hanchar AJ (1979) Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol-HCl, NaOH, hypertonic NaCl and thermal injury. Gastroenterol 77(3):433–443Google Scholar
  50. Sanjay L, Bandana R, Shantilata O (2000) Anti inflammatory activity of neem seed oil. Ind J pharmacol 33:303Google Scholar
  51. Shirwaikar A, Ram HN, Mohapatra P (2006) Antioxidant and antiulcer activity of aqueous extract of a polyherbal formulation. Indian J ExpBiol 44:474–480 http://hdl.handle.net/123456789/6522 Google Scholar
  52. Sahoo SC, Anjana T, Seik WN, Pance N (2012) Glucosamine salts: resolving ambiguities over the market-based compositions. Cryst Growth Des 12:5148–5154.  https://doi.org/10.1021/cg301276y CrossRefGoogle Scholar
  53. Seo PJ, Nayoung K, Joo-Hyon K, Byoung H, Lee R, Hee N, Lee HS, Ji Hyun P, Lee MK, Chang H, Jung HC, Song SI (2012) Comparison of indomethacin, diclofenac and aspirin-induced gastric damage according to age in rats. Gut and Liver 6(2):210–217.  https://doi.org/10.5009/gnl.2012.6.2.210 CrossRefGoogle Scholar
  54. Shalaby ALG, Esawy MA, MEl H (2017) Comparative study between free and immobilized Penicillium chrysogenum mannanase: a local fungal isolate. Biocatal Agric Biotechnol 7(06):97–104.  https://doi.org/10.7324/JAPS.2017.70613 Google Scholar
  55. Suflet DM, Chitanu GC, Valentin IP (2006) Phosphorylation of polysaccharides: new results on synthesis and characterisation of phosphorylated cellulose. React Funct Polym 66:1240–1249.  https://doi.org/10.1016/j.reactfunctpolym.2006.03.006 CrossRefGoogle Scholar
  56. Sun RC, Tomkinson J, Ma PL, Liang SF (2000) Comparative study of hemicelluloses from rice straw by alkali and hydrogen peroxide treatment. Carbohydr Polym 42:111–122.  https://doi.org/10.1016/S0144-8617(99)00136-8 CrossRefGoogle Scholar
  57. Thygesen A, Oddershede J, Lilholt H, Thomsen AB, Stahl K (2005) On the determination of crystallinity and cellulose content in plant fibres. Cellulose 12:563–576CrossRefGoogle Scholar
  58. Vieira RGP (2004) Síntese e caracterização da metilcelulose a partir da metilaçãoheterogênea do bagaço de cana-de-açúcar, Dissetação de Mestrado, Federal University of Uberlândia, BrazilGoogle Scholar
  59. Vieira RGP, Rodrigues FG, Assunção RMN, Meireles CS, Vieira JG, Oliveira GS (2007) Synthesis and characterization of methylcellulose from sugar cane bagasse cellulose. Carbohydr Polym 67:182–189.  https://doi.org/10.1016/j.carbpol.2006.05.007 CrossRefGoogle Scholar
  60. Vieira JG, Guimes RF, da Carla SM, FAC F, Dayane D, Gomided D, Pasquini D, Sebastião F, da Cruz S, Rosana MN, de Assunção RMN, Motta LAC (2012) Synthesis and characterization of methylcellulose from cellulose extracted from mango seeds for use as a mortar additive. Polímero 22(1):80–87.  https://doi.org/10.1590/S0104-14282012005000011 CrossRefGoogle Scholar
  61. Warner TD1, Giuliano F, Vojnovic I, Bukasa A, Mitchell JA, Vane JR (1999) Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc Natl Acad Sci US A 96(13):7563–7568.  https://doi.org/10.1073/pnas.96.13.7563 CrossRefGoogle Scholar
  62. Waldum HL, Arnestad JS, Brenna E, Eide I, Severest U, Sandvik AK (1996) Marked increase in gastric acid secretory capacity after omeprazole treatment. Gut 39:649–653CrossRefGoogle Scholar
  63. Wilkie JS (1961) Carl Nageli and the fine structure of living matter. Nature 190:1145–1150CrossRefGoogle Scholar
  64. Winter CA, Risley EA, Nuss GW (1962) Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatorydrugs. ProcSocExpBiol Med 111:544–547.  https://doi.org/10.3181/00379727-111-27849 Google Scholar
  65. Xue J, Ngadi M (2009) Effect of some hydrocolloids on reducing oil uptake and quality factors of fermented donuts. FoodHydrocoll 23:286–295Google Scholar
  66. Yang XB, Gao XD, Han F, Tan RX (2005) Sulfation of a polysaccharide produced by a marine filamentous fungus Phoma herbarum YS4108 alters its antioxidant properties in vitro. Biochim Biophys Acta 1725:120–127.  https://doi.org/10.1016/j.bbagen.2005.06.013 CrossRefGoogle Scholar
  67. Ye DY, Farriol X (2007) Preparation and characterization of methylcelluloses from some annual plant pulps. Ind Crop Prod 26:54–62.  https://doi.org/10.1016/j.indcrop.2007.01.004 CrossRefGoogle Scholar
  68. Zeid IF, Kassem EM, Mohamed N. A., Salman AA, Shalaby AG (2018). Enhancement of different biomedical activities of newly synthesized quinazoline derivatives. JHET doi  https://doi.org/10.1002/j.het.3147

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Tamer I. M. Ragab
    • 1
  • Al Shimaa Gamal Shalaby
    • 1
  • Sally A. El Awdan
    • 2
  • Ahmed Refaat
    • 3
  • Wafaa A. Helmy
    • 1
  1. 1.Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Division, National Research CentreGizaEgypt
  2. 2.Department of Pharmacology, National Research CentreGizaEgypt
  3. 3.Spectroscopy Department, National Research CentreCairoEgypt

Personalised recommendations