Environmental Science and Pollution Research

, Volume 25, Issue 20, pp 19962–19974 | Cite as

Determination of nine pharmaceutical active compounds in surface waters from Paraopeba River Basin in Brazil by LTPE-HPLC-ESI-MS/MS

  • André Luis Correa de Barros
  • Felix Florian Schmidt
  • Sérgio Francisco de Aquino
  • Robson José de Cássia Franco AfonsoEmail author
Research Article


A simple, inexpensive, versatile, and environment-friendly extraction method, using low-temperature partitioning extraction (LTPE), was validated to quantify pharmaceutical-active compounds (PhACs) in surface water samples by high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS). The PhACs analyzed were acetaminophen, bezafibrate, diclofenac, diltiazem, fluconazole, linezolid, miconazole, ondansetron hydrochloride, and trimethoprim. The detection and quantification limits ranged from 0.15 to 12.30 ng L−1 and 0.43 to 40.60 ng L−1, respectively. Recovery rates ranged from 46 to 135%, and relative standard deviation (RSD%) varied between 0.49 and 6.13%. This method was applied to monitor water contamination by PhACs in the Paraopeba River Basin (PRB), Minas Gerais state, Brazil. All PhACs, except linezolid which was not detected, were found in PRB water samples in concentrations that ranged from 2.6 ng L−1 to 2.62 μg L−1.


Pharmaceuticals HPLC-ESI-MS/MS Low-temperature partitioning extraction Surface water 



The authors would like to thank the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), the Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG), the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), and the Universidade Federal de Ouro Preto for their financial support, and the Instituto Mineiro de Gestão das Águas (IGAM) for the partnership.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • André Luis Correa de Barros
    • 1
  • Felix Florian Schmidt
    • 2
    • 3
  • Sérgio Francisco de Aquino
    • 4
  • Robson José de Cássia Franco Afonso
    • 4
    Email author
  1. 1.Environmental Engineering Postgraduate Program (Proamb)Universidade Federal de Ouro Preto (UFOP)Ouro PretoBrazil
  2. 2.Undergraduate Exchange ProgramUniversidade Federal de Ouro Preto (UFOP)Ouro PretoBrazil
  3. 3.Natural and Medical Sciences InstituteUniversity of TuebingenReutlingenGermany
  4. 4.Chemistry DepartmentUniversidade Federal de Ouro Preto (UFOP)Ouro PretoBrazil

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