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Environmental Science and Pollution Research

, Volume 24, Issue 23, pp 19282–19292 | Cite as

Occurrence, distribution, and risk assessment of antibiotics in the Songhua River in China

  • Weihua Wang
  • He Wang
  • Wanfeng Zhang
  • Hong LiangEmail author
  • Dawen GaoEmail author
Research Article

Abstract

The occurrence, distribution, and risk assessment of antibiotics in freshwater systems are receiving global attention, because of their impact on the environment and human health. However, few studies have focused on this topic in Northeast China and its Songhua River, the third-largest river in China. This study investigated the occurrence and distribution of 12 antibiotics, including three cephalosporins (cefazolin, cefmetazole, cefotaxime), three macrolides (azithromycin, clarithromycin, roxithromycin), three fluoroquinolones (ofloxacin, norfloxacin, flumequine), and three sulfonamides (sulfadiazine, sulfapyridine, sulfamethoxazole) in the mainstream and tributaries of the Songhua River. A total of 152 surface water samples were collected in January, May, July, and October 2016. These samples were analyzed using solid-phase extraction (SPE) and ultra-high-performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS). The results indicated the wide use of all 12 antibiotics in the mainstream of the Songhua River. Sulfamethoxazole and cefazolin were the dominant antibiotics, with maximum concentrations of 73.1 and 65.4 ng L−1, respectively. Other antibiotics were present at mean concentrations below 15 ng L−1, except cefmetazole, present at a mean concentration of 35.6 ng L−1. The spatial distribution of antibiotics showed that unbalanced regional development may lead to the distribution pattern of the antibiotics in the tributaries and the mainstream. Thus study also assessed the seasonal variation of antibiotics in urban surface water; cephalosporin, sulfonamide, fluoroquinolone, and macrolide concentrations were significantly higher during the icebound season than during non-icebound season. This may be due to the low temperature and water flow of the river in winter. Risk assessment showed that azithromycin, clarithromycin, roxithromycin, flumequine, and sulfamethoxazole posed a low or median risk to the aquatic organisms in the mainstream. The potential risks created by antibiotics to the aquatic environment should not be neglected in the Songhua River. The potential risks created by antibiotics to the aquatic environment should not be neglected in the Songhua River.

Keywords

Antibiotics Surface water Risk assessment Icebound season 

Notes

Acknowledgments

This work was supported by the National Natural Science Foundation of China (No. 31470543).

Supplementary material

11356_2017_9471_MOESM1_ESM.doc (541 kb)
ESM 1 (DOC 541 kb)

References

  1. Ali AM, Rønning HT, Alarif W, Kallenborn R, Al-Lihaibi SS (2017) Occurrence of pharmaceuticals and personal care products in effluent-dominated Saudi Arabian coastal waters of the Red Sea. Chemosphere 175:505–513CrossRefGoogle Scholar
  2. Arikan OA, Rice C, Codling E (2008) Occurrence of antibiotics and hormones in a major agricultural watershed. Desalination 226:121–133CrossRefGoogle Scholar
  3. Boxall AB, Blackwell P, Cavallo R, Kay P, Tolls J (2002) The sorption and transport of a sulphonamide antibiotic in soil systems. Toxicol Lett 131:19–28CrossRefGoogle Scholar
  4. Bu QW, Wang B, Huang J, Deng SB, Yu G (2013) Pharmaceuticals and personal care products in the aquatic environment in China: a review. J Hazard Mater 262:189–211CrossRefGoogle Scholar
  5. Burke V, Richter D, Greskowiak J, Mehrtens A, Schulz L, Massmann G (2016) Occurrence of antibiotics in surface and groundwater of a drinking water catchment area in Germany. Water Environ Res 88:652–659CrossRefGoogle Scholar
  6. Chen K, Zhou JL (2014) Occurrence and behavior of antibiotics in water and sediments from the Huangpu River, Shanghai, China. Chemosphere 95:604–612CrossRefGoogle Scholar
  7. Chen YM, Leung KSY, Wong JWC, Selvam A (2013) Preliminary occurrence studies of antibiotic residues in Hong Kong and Pearl River Delta. Environ Monit Assess 185:745–754CrossRefGoogle Scholar
  8. Dirany A, Sirés I, Oturan N, Ozcan A, Oturan MA (2012) Electrochemical treatment of the antibiotic sulfachloropyridazine: kinetics, reaction pathways, and toxicity evolution. Environ Sci Technol 46:4074–4082CrossRefGoogle Scholar
  9. Du J, Zhao H, Liu S, Xie H, Wang Y, Chen J (2017) Antibiotics in the coastal water of the South Yellow Sea in China: occurrence, distribution and ecological risks. Sci Total Environ 595:521–527CrossRefGoogle Scholar
  10. Duong HA, Pham NH, Nguyen HT, Hoang TT, Pham HV, Pham VC, Berg M, Giger W, Alder AC (2008) Occurrence, fate and antibiotic resistance of fluoroquinolone antibacterials in hospital wastewaters in Hanoi, Vietnam. Chemosphere 72:968–973CrossRefGoogle Scholar
  11. Galvachin J, Katz SE (1994) The persistence of fecal-borne antibiotics in soil. J AOAC Int 77:481–487Google Scholar
  12. Gao LH, Shi YL, Li WH, Liu JM, Cai YQ (2012) Occurrence, distribution and bioaccumulation of antibiotics in the Haihe River in China. J Environ Monit 14:1248–1255CrossRefGoogle Scholar
  13. Graham DW, Olivares-Rieumont S, Knapp CW, Lima L, Werner D, Bowen E (2011) Antibiotic resistance gene abundances associated with waste discharges to the Almendares River near Havana, Cuba. Environ Sci Technol 45:418–424CrossRefGoogle Scholar
  14. Harris SJ, Cormican M, Cummins E (2012) Antimicrobial residues and antimicrobial-resistant bacteria: impact on the microbial environment and risk to human health—a review. Hum Ecol Risk Assess 18:767–809CrossRefGoogle Scholar
  15. Huang CH, Renew JE, Smeby KL, Pinkston K, Sedlak DL (2011) Assessment of potential antibiotic contaminants in water and preliminary occurrence analysisGoogle Scholar
  16. Hvistendahl M (2012) China takes aim at rampant antibiotic resistance. Science 336:795–795CrossRefGoogle Scholar
  17. Jiang L, Hu X, Xu T, Zhang H, Sheng D, Yin D (2013) Prevalence of antibiotic resistance genes and their relationship with antibiotics in the Huangpu River and the drinking water sources, Shanghai, China. Sci Total Environ 458-460:267–272CrossRefGoogle Scholar
  18. Kim S-C, Carlson K (2007) Temporal and spatial trends in the occurrence of human and veterinary antibiotics in aqueous and river sediment matrices. Environ Sci Technol 41:50–57CrossRefGoogle Scholar
  19. Klosterhaus SL, Grace R, Hamilton MC, Yee D (2013) Method validation and reconnaissance of pharmaceuticals, personal care products, and alkylphenols in surface waters, sediments, and mussels in an urban estuary. Environ Int 54:92–99CrossRefGoogle Scholar
  20. Kummerer K (2009a) Antibiotics in the aquatic environment—a review—part I. Chemosphere 75:417–434CrossRefGoogle Scholar
  21. Kummerer K (2009b) Antibiotics in the aquatic environment—a review—part II. Chemosphere 75:435–441CrossRefGoogle Scholar
  22. Li W, Shi Y, Gao L, Liu J, Cai Y (2012) Occurrence of antibiotics in water, sediments, aquatic plants, and animals from Baiyangdian Lake in North China. Chemosphere 89:1307–1315CrossRefGoogle Scholar
  23. Li W, Gao L, Shi Y, Liu J, Cai Y (2015) Occurrence, distribution and risks of antibiotics in urban surface water in Beijing, China. Environ Sci-Process Impacts 17:1611CrossRefGoogle Scholar
  24. Liang X, Chen B, Nie X, Shi Z, Huang X, Li X (2013) The distribution and partitioning of common antibiotics in water and sediment of the Pearl River Estuary, South China. Chemosphere 92:1410–1416CrossRefGoogle Scholar
  25. Liao XB, Li BX, Zou RS, Dai Y, Xie SG, Yuan BL (2016) Biodegradation of antibiotic ciprofloxacin pathways, influential factors, and bacterial community structure. Environ Sci Pol 23:7911–7918CrossRefGoogle Scholar
  26. Lindberg RH, Wennberg P, Johansson MI, Tysklind M, Andersson BAV (2007) Screening of human antibiotic substances and determination of weekly mass flows in five sewage treatment plants in Sweden. Le Journal De Physique Colloques 39:3421–3429Google Scholar
  27. Llorca M, Gros M (2014) Sample preservation for the analysis of antibiotics in water. J Chromatogr A 1369:43–51CrossRefGoogle Scholar
  28. Managaki S, Murata A, Takada H, Tuyen BC, Chiem NH (2007) Distribution of macrolides, sulfonamides, and trimethoprim in tropical waters: ubiquitous occurrence of veterinary antibiotics in the Mekong Delta. Environ Sci Technol 41:8004–8010CrossRefGoogle Scholar
  29. Moreno-González R, Rodriguez-Mozaz S, Gros M, Barceló D, León VM (2015) Seasonal distribution of pharmaceuticals in marine water and sediment from a mediterranean coastal lagoon (SE Spain). Environ Res 138:326–344CrossRefGoogle Scholar
  30. Nödler K, Voutsa D, Licha T (2014) Polar organic micropollutants in the coastal environment of different marine systems. Mar Pollut Bull 85:50–59CrossRefGoogle Scholar
  31. Quesada-Molina C, Olmo-Iruela MD, García-Campaña AM (2012) Analysis of cephalosporin residues in environmental waters by capillary zone electrophoresis with off-line and on-line preconcentration. Anal Methods-UK 4:2341–2347CrossRefGoogle Scholar
  32. Sacher F, Lange FT, Brauch HJ, Blankenhorn I (2001) Pharmaceuticals in groundwaters analytical methods and results of a monitoring program in Baden-Württemberg, Germany. J Chromatogr A 938:199–210CrossRefGoogle Scholar
  33. Sarmah AK, Meyer MT, Boxall ABA (2006) A global perspective on the use, sales, exposure pathways, occurrence, fate and effects of veterinary antibiotics (VAs) in the environment. Chemosphere 65:725–759CrossRefGoogle Scholar
  34. Selvam A, Kwok K, Chen Y, Cheung A, Leung KSY, Wong JWC (2017) Influence of livestock activities on residue antibiotic levels of rivers in Hong Kong. Environ Sci Pollut Res 24:9058–9066CrossRefGoogle Scholar
  35. Straub JO (2015) Aquatic environmental risk assessment for human use of the old antibiotic sulfamethoxazole in Europe. Environ Toxicol Chem 35:767–779CrossRefGoogle Scholar
  36. Tamtam F, Mercier F, Le BB, Eurin J, Tuc DQ, Clément M, Chevreuil M (2008) Occurrence and fate of antibiotics in the Seine River in various hydrological conditions. Sci Total Environ 393:84–95CrossRefGoogle Scholar
  37. US Environmental Protection Agency (2012) Estimation Program Interface EPI, suite, version. Environmental Protection Agency, Office of Pollution Prevention and Toxic's, Washington, DC, USAGoogle Scholar
  38. Wang XH, Lin AY (2012) Phototransformation of cephalosporin antibiotics in an aqueous environment results in higher toxicity. Environ Sci Technol 46:12417–12426CrossRefGoogle Scholar
  39. Wen Q, Yang L, Duan R, Chen Z (2016) Monitoring and evaluation of antibiotic resistance genes in four municipal wastewater treatment plants in Harbin, Northeast China. Environ Pollut 212:34–40CrossRefGoogle Scholar
  40. Winckler C, Grafe A (2001) Use of veterinary drugs in intensive animal production. J Soils Sediments 1:66–70CrossRefGoogle Scholar
  41. Wu XL, Xiang L, Yan QY, Jiang YN, Li YW, Huang XP, Li H, Cai QY, Mo CH (2014) Distribution and risk assessment of quinolone antibiotics in the soils from organic vegetable farms of a subtropical city, Southern China. Sci Total Environ 487:399–406CrossRefGoogle Scholar
  42. Wu MH et al (2016) Distribution, fate, and risk assessment of antibiotics in five wastewater treatment plants in Shanghai, China. Environ Sci Pollut Res 23:18055–18063. doi: 10.1007/s11356-016-6946-0 CrossRefGoogle Scholar
  43. Xiang L, Wu XL, Jiang YN, Yan QY, Li YW, Huang XP, Li H, Cai QY, Mo CH (2016) Occurrence and risk assessment of tetracycline antibiotics in soil from organic vegetable farms in a subtropical city, south China. Environ Sci Pollut Res 23:13984–13995CrossRefGoogle Scholar
  44. Xu WH, Yan W, Li XD, Zou YD, Chen XX, Huang WX, Miao L, Zhang RJ, Zhang G, Zou SC (2013) Antibiotics in riverine runoff of the Pearl River Delta and Pearl River Estuary, China: concentrations, mass loading and ecological risks. Environ Pollut 182:402–407CrossRefGoogle Scholar
  45. Yan C, Yang Y, Zhou J, Liu M, Nie M, Shi H, Gu L (2013) Antibiotics in the surface water of the Yangtze Estuary: occurrence, distribution and risk assessment. Environ Pollut 175:22–29CrossRefGoogle Scholar
  46. Yang JF, Ying GG, Zhao JL, Tao R, Su HC, Chen F (2010) Simultaneous determination of four classes of antibiotics in sediments of the Pearl Rivers using RRLC–MS/MS. Sci Total Environ 408:3424–3432CrossRefGoogle Scholar
  47. Yang G, Fan M, Zhang G (2014a) Emerging contaminants in surface waters in China—a short review. Environ Res Lett 9:1195–1206CrossRefGoogle Scholar
  48. Yu X, Tang X, Zuo J, Zhang M, Chen L, Li Z (2016) Distribution and persistence of cephalosporins in cephalosporin producing wastewater using SPE and UPLC-MS/MS method. Sci Total Environ 569–570:23–30CrossRefGoogle Scholar
  49. Zhang RJ, Tang JH, Li J, Zheng Q, Liu D, Chen YJ, Zou YD, Chen XX, Luo CL, Zhang G (2013) Antibiotics in the offshore waters of the Bohai Sea and the Yellow Sea in China: occurrence, distribution and ecological risks. Environ Pollut 174:71–77CrossRefGoogle Scholar
  50. Zhang QQ, Ying GG, Pan CG, Liu YS, Zhao JL (2015) Comprehensive evaluation of antibiotics emission and fate in the river basins of China: source analysis, multimedia modeling, and linkage to bacterial resistance. Environ Sci Technol 49:6772–6782CrossRefGoogle Scholar
  51. Zhang R, Zhang R, Li J, Cheng Z, Luo C, Wang Y, Yu K, Zhang G (2017) Occurrence and distribution of antibiotics in multiple environmental media of the East River (Dongjiang) catchment, South China. Environ Sci Pollut Res 24:9690–9701. doi: 10.1007/s11356-017-8664-7 CrossRefGoogle Scholar
  52. Zhou L, Ying G, Zhao J, Yang J, Wang L, Yang B, Liu S (2011) Trends in the occurrence of human and veterinary antibiotics in the sediments of the Yellow River, Hai River and Liao River in northern China. Environ Pollut 159:1877–1885CrossRefGoogle Scholar
  53. Zhou H, Ying T, Wang X, Liu J (2016) Occurrence and preliminarily environmental risk assessment of selected pharmaceuticals in the urban rivers, China. Sci Rep-Uk 6Google Scholar
  54. Zou SC, Xu WH, Zhang RJ, Tang JH, Chen YJ, Zhang G (2011) Occurrence and distribution of antibiotics in coastal water of the Bohai Bay, China: impacts of river discharge and aquaculture activities. Environ Pollut 159:2913–2920CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  1. 1.Center for Ecological ResearchNortheast Forestry UniversityHarbinChina
  2. 2.Harbin Environmental Monitoring CenterHarbinChina
  3. 3.School of ForestryNortheast Forestry UniversityHarbinChina

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