Environmental Science and Pollution Research

, Volume 24, Issue 11, pp 10621–10629

Hepatic transcriptomic responses in mice exposed to arsenic and different fat diet

Research Article

DOI: 10.1007/s11356-017-8743-9

Cite this article as:
Hou, H., Yu, Y., Shen, Z. et al. Environ Sci Pollut Res (2017) 24: 10621. doi:10.1007/s11356-017-8743-9


Chronic exposure to inorganic arsenic (iAs) or a high-fat diet (HFD) can produce liver injury. However, effects of HFD on risk assessment of iAs in drinking water are unclear. In this study, we examined how HFD and iAs interact to alter iAs-induced liver injury in C57BL/6 mice. Mice fed low-fat diet (LFD) or HFD were exposed to 3 mg/L iAs or deionized water for 10 weeks. Results showed that HFD changed intake and excretion of iAs by mice. Then, HFD increased the amount of iAs-induced hepatic DNA damage and amplified changes in pathways related to cell death and growth, signal transduction, lipid metabolism, and insulin signaling. Compared to gene expression profiles caused by iAs alone or HFD alone, insulin signaling pathway might play important roles in the interactive effects of iAs and HFD. Our data suggest that HFD increases sensitivity of mice to iAs in drinking water, resulting in increased hepatotoxicity. This study highlight that HFD might enhance the risk of iAs hepatotoxicity in iAs-polluted regions. The diet should be considered during risk assessment of iAs in drinking water.


Transcriptomic profiles High-fat diet Arsenic Hepatotoxicity Drinking water Mice 

Supplementary material

11356_2017_8743_MOESM1_ESM.docx (7.2 mb)
ESM 1(DOCX 7412 kb)

Funding information

Funder NameGrant NumberFunding Note
Natural Science Foundation of Jiangsu Province
  • BK20131270
Foundation of State Key Laboratory of Pollution Control and Resource Reuse
    Science Foundation of Nanjing University

      Copyright information

      © Springer-Verlag Berlin Heidelberg 2017

      Authors and Affiliations

      • Hui Hou
        • 1
      • Yue Yu
        • 1
      • Zhuoyan Shen
        • 1
      • Su Liu
        • 1
      • Bing Wu
        • 1
      1. 1.State Key Laboratory of Pollutant Control and Resource Reuse, School of the EnvironmentNanjing UniversityNanjingPeople’s Republic of China

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