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Alleviation of lead-induced oxidative stress and immune damage by selenium in chicken bursa of Fabricius

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Abstract

We investigated lead (Pb)-induced oxidative stress and immune damage in the chicken bursa of Fabricius (BF) and the ameliorative effect of selenium (Se). Seven-day-old male chickens were randomly divided into four groups and were provided standard diet and drinking water, Na2SeO3 added to the standard diet and drinking water, standard diet and (CH3COO)2Pb added to drinking water, and Na2SeO3 added to the standard diet and (CH3COO)2Pb added to drinking water for 30, 60, and 90 days. The presence of Pb inhibited total antioxidant capacity (T-AOC), glutathione peroxidase (GPx), glutathione S-transferase (GST), superoxide dismutase (SOD), and catalase (CAT) activities; decreased glutathione (GSH) content; increased malondialdehyde (MDA) and hydrogen peroxide (H2O2) contents; inhibited interleukin (IL)-2 and interferon-γ (IFN-γ) messenger RNA (mRNA) expression; and increased IL-4, IL-6, IL-10, IL-12β, and IL-17 mRNA expression. The presence of Se relieved all of the above Pb-induced changes. There were close correlations among GSH, CAT, T-AOC, SOD, GPx, MDA, and H2O2 and among IL-2, IL-4, IL-6, IL-12β, IL-17, and IFN-γ. Our data showed that Pb caused oxidative stress and immune damage in the chicken BF. Se alleviated Pb-induced oxidative stress and immune damage in the chicken BF.

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Acknowledgements

This study was funded by the Scientific Research Projects of Education Department of Heilongjiang Province (No. 12541006) and the Heilongjiang Province on Natural Fund Project (No. 41400172-4-14089).

All authors have read the manuscript and agreed to submit it for consideration in its current form for publication in Environmental Science and Pollution Research.

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Correspondence to Xiaojie Teng or Xiaohua Teng.

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The authors declare that they have no conflicts of interest.

Additional information

Xiaoyan Jiao and Kai Yang contributed equally and should be considered co-first authors.

Responsible editor: Philippe Garrigues

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Jiao, X., Yang, K., An, Y. et al. Alleviation of lead-induced oxidative stress and immune damage by selenium in chicken bursa of Fabricius. Environ Sci Pollut Res 24, 7555–7564 (2017). https://doi.org/10.1007/s11356-016-8329-y

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Keywords

  • Lead
  • Selenium
  • Chicken
  • Bursa of Fabricius
  • Cytokine
  • Oxidative stress