Environmental Science and Pollution Research

, Volume 23, Issue 14, pp 14284–14293 | Cite as

Body burden of persistent organic pollutants on hypertension: a meta-analysis

  • Su Hyun Park
  • Jung-eun Lim
  • Hyesook Park
  • Sun Ha Jee
Research Article
First Online:
Received:
Accepted:

Abstract

Except the known risk factors for hypertension, several studies have suggested that exposure to persistent organic pollutants (POPs), endocrine disrupting chemicals, could be associated with an increased risk of hypertension. In this study, we performed a meta-analysis to summarize the existing epidemiological studies to investigate the association between POPs concentration and risk of hypertension. Based on comprehensive literature search results (PubMed, EMBASE, and KoreaMed), a meta-analysis of 11 articles was performed using a random-effects model. While we observed no significant association between the sum of non-dioxin-like PCBs and the risk of hypertension (OR = 1.00; 95 % CI 0.89, 1.12), the sum of dioxin-like PCBs was associated with a significantly increased risk of hypertension (OR = 1.45; 95 % CI 1.00, 2.12). High p,p′-DDE level was also significantly associated with the increased risk of hypertension. When subgroup analyses were carried out for studies which analyzed POPs concentrations using high-resolution gas chromatography/high-resolution mass spectrometry, the overall pooled estimate ORs increased with decreased heterogeneity, providing it as a possible heterogeneity source (OR = 1.36; 95 % CI 1.21, 1.52; I 2 = 42.8 %; p = 0.045). This study suggested that the concentration of certain POPs, especially dioxin-related compounds, was associated with the risk of hypertension.

Keywords

Blood pressure Hypertension Endocrine disruptors Polychlorinated biphenyls 
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Notes

Acknowledgments

This research was supported by a grant (13162MFDS891) from the Ministry of Food and Drug Safety in 2013 and a grant (15162MFDS631) from the Ministry of Food and Drug Safety in 2015.

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.

Supplementary material

11356_2016_6568_MOESM1_ESM.docx (32 kb)
Table S1 (DOCX 32 kb)
11356_2016_6568_MOESM2_ESM.docx (20 kb)
Table S2 (DOCX 19 kb)
11356_2016_6568_MOESM3_ESM.docx (25 kb)
Figure S1 (DOCX 24 kb)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Su Hyun Park
    • 1
  • Jung-eun Lim
    • 2
    • 3
  • Hyesook Park
    • 1
  • Sun Ha Jee
    • 2
  1. 1.Department of Preventive Medicine, School of MedicineEwha Womans UniversitySeoulKorea
  2. 2.Institute for Health Promotion & Department of Epidemiology and Health Promotion, Graduate School of Public HealthYonsei UniversitySeoulKorea
  3. 3.Department of Public Health, Graduate SchoolYonsei UniversitySeoulKorea

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