Environmental Science and Pollution Research

, Volume 23, Issue 10, pp 9459–9479 | Cite as

Application of liquid chromatography-tandem mass spectrometry in quantitative bioanalyses of organic molecules in aquatic environment and organisms

  • Ugo Bussy
  • Ke Li
  • Weiming LiEmail author
Review Article


Analytical methods using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) for the simultaneous determination of metabolites or contaminants (or both) in various tissues of aquatic organisms and in the aquatic environment have received increasing attention in the last few years. This review discusses the findings relevant to such procedures published between 2005 and 2015. The aim is to evaluate the advantages, restrictions, and performances of the procedures from sample preparation to mass spectrometry measurement. To support these discussions, a general knowledge on LC-MS/MS is also provided.


Liquid chromatography-tandem mass spectrometry LC-MS/MS Sample preparation Pharmaceuticals Emergent pollutants Aquatic organisms Environmental water 


Compliance with ethical standards


This study was funded by grants from the Great Lakes Fishery Commission.

Conflict of interest

The authors declare that they have no competing interests.


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© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Department of Fisheries and WildlifeMichigan State UniversityEast LansingUSA

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