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Association of bisphenol A exposure with overweight in the elderly: a panel study

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Bisphenol A (BPA) is an ubiquitous chemical, which is an endocrine disruptor. Recent epidemiological studies have suggested a relationship between BPA exposure and body weight. However, most of these studies were cross-sectional and not on elderly people. We conducted a panel study with repeated measurements to evaluate the relationship between BPA and overweight in elderly people. A total of 560 elderly participants aged ≥60 years were recruited in Seoul from 2008 to 2010. Urinary BPA levels and body mass index (BMI, kg/m2) were measured at every visit. We defined a BMI ≥25 as overweight and examined the relations between urinary BPA and BMI or overweight. Repeated measures analysis was performed after adjusting for age, sex, low-density lipoprotein cholesterol levels, alcohol consumption, regular exercise, total calorie intake, fatty acid intake, urinary cotinine levels, and the status of diabetes mellitus. The geometric mean of BPA was 0.67 μg/g creatinine. The odds ratio (OR) of overweight was 1.17 (95 % confidence interval [CI] 1.04–1.32) per interquartile range increase of log-transformed BPA. When stratified based on sex, we observed a significant association in women (OR 1.25; 95 % CI 1.09–1.45) but not in men (OR 0.97; 95 % CI 0.77–1.22). The ORs of overweight increased with quartiles of BPA in women (quartile 2 vs 1: OR 1.54; 95 % CI 1.02–2.32, 3 vs 1: OR 1.70; 95 % CI 1.10–2.62, and 4 vs 1: OR 1.81; 95 % CI 1.13–2.92). Our results suggest that urinary BPA levels are significantly associated with overweight in elderly women but not elderly men.

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  1. Aballay LR, Eynard AR, Diaz Mdel P, Navarro A, Munoz SE (2013) Overweight and obesity: a review of their relationship to metabolic syndrome, cardiovascular disease, and cancer in South America. Nutr Rev 71:168–179. doi:10.1111/j.1753-4887.2012.00533.x

  2. Alonso-Magdalena P, Morimoto S, Ripoll C, Fuentes E, Nadal A (2006) The estrogenic effect of bisphenol A disrupts pancreatic beta-cell function in vivo and induces insulin resistance. Environ Health Perspect 114:106–112

  3. Alonso-Magdalena P, Quesada I, Nadal A (2011) Endocrine disruptors in the etiology of type 2 diabetes mellitus Nature reviews. Endocrinology 7:346–353. doi:10.1038/nrendo.2011.56

  4. Bae S, Kim JH, Lim YH, Park HY, Hong YC (2012) Associations of bisphenol A exposure with heart rate variability and blood pressure. Hypertension 60:786–793. doi:10.1161/hypertensionaha.112.197715

  5. Ben-Jonathan N, Hugo ER, Brandebourg TD (2009) Effects of bisphenol A on adipokine release from human adipose tissue: Implications for the metabolic syndrom. Mol Cell Endocrinol 304:49–54. doi:10.1016/j.mce.2009.02.022

  6. Bhandari R, Xiao J, Shankar A (2013) Urinary Bisphenol A and Obesity in US Children. Am J Epidemiol. doi:10.1093/aje/kws391

  7. Boucher JG, Boudreau A, Atlas E (2014) Bisphenol A induces differentiation of human preadipocytes in the absence of glucocorticoid and is inhibited by an estrogen-receptor antagonist. Nutr Diabetes 4:e102. doi:10.1038/nutd.2013.43

  8. Calafat AM, Ye X, Wong LY, Reidy JA, Needham LL (2008) Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004. Environ Health Perspect 116:39–44. doi:10.1289/ehp.10753

  9. Carwile JL, Michels KB (2011) Urinary bisphenol A and obesity: NHANES 2003-2006. Environ Res 111:825–830. doi:10.1016/j.envres.2011.05.014

  10. CDC (2014) Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables. National Center for Environmental Health Division of Laboratory Sciences. http://www.cdc.gov/exposurereport/pdf/FourthReport_UpdatedTables_Jul2014.pdf. Accessed 7th August 2014

  11. Chen CC et al (2008) Association among cigarette smoking, metabolic syndrome, and its individual components: the metabolic syndrome study in Taiwan. Metab Clin Exp 57:544–548. doi:10.1016/j.metabol.2007.11.018

  12. Christensen KL, Lorber M, Koslitz S, Bruning T, Koch HM (2012) The contribution of diet to total bisphenol A body burden in humans: results of a 48 hour fasting study. Environ Int 50:7–14. doi:10.1016/j.envint.2012.09.002

  13. Dekant W, Volkel W (2008) Human exposure to bisphenol A by biomonitoring: methods, results and assessment of environmental exposures. Toxicol Appl Pharmacol 228:114–134. doi:10.1016/j.taap.2007.12.008

  14. Fernandez MF (2007) Bisphenol-A and chlorinated derivatives in adipose tissue of women. Reprod Toxicol (Elmsford, NY) 24:259–264. doi:10.1016/j.reprotox.2007.06.007

  15. Gregoire FM, Smas CM, Sul HS (1998) Understanding adipocyte differentiation. Physiol Rev 78:783–809

  16. Harley KG et al (2013) Prenatal and postnatal bisphenol A exposure and body mass index in childhood in the CHAMACOS Cohort. Environ Health Perspect 121:514–520. doi:10.1289/ehp.1205548

  17. Hugo ER, Brandebourg TD, Woo JG, Loftus J, Alexander JW, Ben-Jonathan N (2008) Bisphenol A at environmentally relevant doses inhibits adiponectin release from human adipose tissue explants and adipocytes. Environ Health Perspect 116:1642–1647. doi:10.1289/ehp.11537

  18. Ishunina TA, Kruijver FP, Balesar R, Swaab DF (2000) Differential expression of estrogen receptor alpha and beta immunoreactivity in the human supraoptic nucleus in relation to sex and aging. J Clin Endocrinol Metab 85:3283–3291

  19. Jackson AS et al (2002) The effect of sex, age and race on estimating percentage body fat from body mass index. Heritage Family Study Int J Obesity and Relat Metab Disord: J Int Ass Study Obesity 26:789–796. doi:10.1038/sj.ijo.0802006

  20. Ko A, Hwang MS, Park JH, Kang HS, Lee HS, Hong JH (2014) Association between urinary Bisphenol A and waist circumference in Korean adults. Toxicol Res 30:39–44. doi:10.5487/tr.2014.30.1.039

  21. Li DK et al (2013) Urine bisphenol-a level in relation to obesity and overweight in school-age children. PLoS One 8:e65399. doi:10.1371/journal.pone.0065399

  22. Mackay H, Patterson ZR, Khazall R, Patel S, Tsirlin D, Abizaid A (2013) Organizational effects of perinatal exposure to bisphenol-A and diethylstilbestrol on arcuate nucleus circuitry controlling food intake and energy expenditure in male and female CD-1 mice. Endocrinology 154:1465–1475. doi:10.1210/en.2012-2044

  23. Masuno H, Iwanami J, Kidani T, Sakayama K, Honda K (2005) Bisphenol a accelerates terminal differentiation of 3 T3-L1 cells into adipocytes through the phosphatidylinositol 3-kinase pathway Toxicological sciences: an official journal of the Society of. Toxicology 84:319–327. doi:10.1093/toxsci/kfi088

  24. Masuno H, Kidani T, Sekiya K, Sakayama K, Shiosaka T, Yamamoto H, Honda K (2002) Bisphenol A in combination with insulin can accelerate the conversion of 3 T3-L1 fibroblasts to adipocytes. J Lipid Res 43:676–684

  25. Matthews JB, Twomey K, Zacharewski TR (2001) In vitro and in vivo interactions of bisphenol A and its metabolite, bisphenol A glucuronide, with estrogen receptors alpha and beta. Chem Res Toxicol 14:149–157

  26. McCracken J et al (2010) Annual ambient black carbon associated with shorter telomeres in elderly men: Veterans Affairs Normative Aging Study. Environ Health Perspect 118:1564–1570

  27. Mervish N et al (2014) Dietary predictors of urinary environmental biomarkers in young girls, BCERP, 2004-7. Environ Res 133c:12–19. doi:10.1016/j.envres.2014.04.040

  28. Nadal A (2013) Obesity: Fat from plastics? Linking bisphenol A exposure and obesity. Nat Rev Endocrinol 9:9–10. doi:10.1038/nrendo.2012.205

  29. Oh SY, Kim EM, Shin MH, Lee SH, Kim JE, Lee HS (2007) Development and validation of food frequency questionnaire for adults. Paper presented at the The Korean Society of Health Promotion Annual Spring Conference, Seoul, Korea; 2007., May 19, 2007

  30. Robins JMR, Rotnitzky A, Zhao LP (1995) Analysis of semiparametric regression models for repeated outcomes in the presence of missing data. J Am Stat Assoc 90:106–121

  31. Rochester JR et al (2013) Bisphenol A and human health: a review of the literature. Reprod Toxicol (Elmsford, NY) 42:132–155. doi:10.1016/j.reprotox.2013.08.008

  32. Rogers JA, Metz L, Yong VW (2013) Review: Endocrine disrupting chemicals and immune responses: a focus on bisphenol-A and its potential mechanisms. Mole Immunol 53:421–430. doi:10.1016/j.molimm.2012.09.013

  33. Rubin BS (2011) Bisphenol A: an endocrine disruptor with widespread exposure and multiple effects. J Steroid Biochem Mole Biol 127:27–34. doi:10.1016/j.jsbmb.2011.05.002

  34. Rubin BS, Soto AM (2009) Bisphenol A: perinatal exposure and body weight. Mole Cell Endocrinology 304:55–62. doi:10.1016/j.mce.2009.02.023

  35. Rudel RA et al (2011) Food packaging and bisphenol A and bis(2-ethyhexyl) phthalate exposure: findings from a dietary intervention. Environ Health Perspect 119:914–920. doi:10.1289/ehp.1003170

  36. Sabanayagam C, Teppala S, Shankar A (2013) Relationship between urinary bisphenol A levels and prediabetes among subjects free of diabetes. Acta Diabetologica 50:625–631. doi:10.1007/s00592-013-0472-z

  37. Shankar A, Teppala S, Sabanayagam C (2012) Urinary bisphenol a levels and measures of obesity: results from the national health and nutrition examination survey 2003-2008 ISRN endocrinology 2012:965243 doi:10.5402/2012/965243

  38. Shin MH et al (2013) J Epidemiol/Japan Epidemiol Assoc 23:122–131

  39. Song Y, Hauser R, Hu FB, Franke AA, Liu S, Sun Q (2014) Urinary concentrations of bisphenol A and phthalate metabolites and weight change: a prospective investigation in US women. Int J Obesity (2005). doi:10.1038/ijo.2014.63

  40. Stahlhut RW, Welshons WV, Swan SH (2009) Bisphenol A data in NHANES suggest longer than expected half-life, substantial nonfood exposure, or both. Environ Health Perspect 117:784–789. doi:10.1289/ehp.0800376

  41. Trasande L, Attina TM, Blustein J (2012) Association between urinary bisphenol A concentration and obesity prevalence in children and adolescents. JAMA: J Am Med Assoc 308:1113–1121. doi:10.1001/2012.jama.11461

  42. Volkel W, Bittner N, Dekant W (2005) Quantitation of bisphenol A and bisphenol A glucuronide in biological samples by high performance liquid chromatography-tandem mass spectrometry. Drug Metab Dispos: Biol Fate Chem 33:1748–1757. doi:10.1124/dmd.105.005454

  43. Volkel W, Colnot T, Csanady GA, Filser JG, Dekant W (2002) Metabolism and kinetics of bisphenol a in humans at low doses following oral administration. Chem Res Toxicol 15:1281–1287

  44. Wada K, Sakamoto H, Nishikawa K, Sakuma S, Nakajima A, Fujimoto Y, Kamisaki Y (2007) Life style-related diseases of the digestive system: endocrine disruptors stimulate lipid accumulation in target cells related to metabolic syndrome. J Pharmacol Sci 105:133–137

  45. Wang B, Wang H, Zhou W, He Y, Zhou Y, Chen Y, Jiang Q (2014) Exposure to bisphenol A among school children in eastern China: a multicenter cross-sectional study. J Expo Sci Environ Epidemiol. doi:10.1038/jes.2014.36

  46. Wang HX, Zhou Y, Tang CX, Wu JG, Chen Y, Jiang QW (2012a) Association between bisphenol A exposure and body mass index in Chinese school children: a cross-sectional study. Environ Health : A Glob Access Sci Sour 11:79. doi:10.1186/1476-069x-11-79

  47. Wang T et al (2012b) Urinary bisphenol A (BPA) concentration associates with obesity and insulin resistance. J Clin Endocrinol Metab 97:E223–E227. doi:10.1210/jc.2011-1989

  48. Wc W (1998) Nutritional Epidemiology. Oxford university press, New York

  49. WHO (2004) Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet 363:157–163. doi:10.1016/s0140-6736(03)15268-3

  50. Xia X, Serrero G (1999) Inhibition of adipose differentiation by phosphatidylinositol 3-kinase inhibitors. J Cell Physiol 178:9–16. doi:10.1002/(sici)1097-4652(199901)178:1<9::aid-jcp2>3.0.co;2-#

  51. Yang YJ, Hong YC, Oh SY, Park MS, Kim H, Leem JH, Ha EH (2009) Bisphenol A exposure is associated with oxidative stress and inflammation in postmenopausal women. Environ Res 109:797–801. doi:10.1016/j.envres.2009.04.014

  52. Ye X et al (2008) Urinary metabolite concentrations of organophosphorous pesticides, bisphenol A, and phthalates among pregnant women in Rotterdam, the Netherlands: the Generation R study. Environ Res 108:260–267. doi:10.1016/j.envres.2008.07.014

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This study was supported by the Environmental Exposures and Health Effects in Elderly Population program (0411-20080013, 0411-20090007, 0411-20100016) of the Ministry of Environment, Republic of Korea.

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The authors declare that they have no conflict of interests.

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Correspondence to Yun-Chul Hong.

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Responsible editor: Philippe Garrigues

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Lee, M., Kim, J.H., Choi, Y. et al. Association of bisphenol A exposure with overweight in the elderly: a panel study. Environ Sci Pollut Res 22, 9370–9377 (2015). https://doi.org/10.1007/s11356-015-4087-5

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  • Bisphenol A
  • BMI
  • Overweight
  • Elderly people
  • Sex difference
  • Panel study