Environmental Science and Pollution Research

, Volume 22, Issue 11, pp 8738–8746 | Cite as

Short-term effects of multiple ozone metrics on daily mortality in a megacity of China

  • Tiantian LiEmail author
  • Meilin Yan
  • Wenjun Ma
  • Jie Ban
  • Tao Liu
  • Hualiang Lin
  • Zhaorong LiuEmail author
Research Article


Epidemiological studies have widely demonstrated association between ambient ozone and mortality, though controversy remains, and most of them only use a certain metric to assess ozone levels. However, in China, few studies have investigated the acute effects of ambient ozone, and rare studies have compared health effects of multiple daily metrics of ozone. The present analysis aimed to explore variability of estimated health effects by using multiple temporal ozone metrics. Six metrics of ozone, 1-h maximum, maximum 8-h average, 24-h average, daytime average, nighttime average, and commute average, were used in a time-series study to investigate acute mortality associated with ambient ozone pollution in Guangzhou, China, using 3 years of daily data (2006–2008). We used generalized linear models with Poisson regression incorporating natural spline functions to analyze the mortality, ozone, and covariate data. We also examined the association by season. Daily 1- and 8-h maximum, 24-h average, and daytime average concentrations yielded statistically significant associations with mortality. An interquartile range (IQR) of O3 metric increase of each ozone metric (lag 2) corresponds to 2.92 % (95 % confidence interval (CI) 0.24 to 5.66), 3.60 % (95 % CI, 0.92 to 8.49), 3.03 % (95 % CI, 0.57 to 15.8), and 3.31 % (95 % CI, 0.69 to 10.4) increase in daily non-accidental mortality, respectively. Nighttime and commute metrics were weakly associated with increased mortality rate. The associations between ozone and mortality appeared to be more evident during cool season than in the warm season. Results were robust to adjustment for co-pollutants, weather, and time trend. In conclusion, these results indicated that ozone, as a widespread pollutant, adversely affects mortality in Guangzhou.


Ambient ozone Non-accidental mortality Metric Time series 



This work was supported by the National Natural Science Foundation of China (project numbers: 21277135, 40905069, 41205081), Beijing National Natural Science Foundation (project number: 8132048), China Environmental Protection Agency (EPA) Charity Special Fund (project number: 201009032), and Guangdong Province medical fund (project number: B2012072)

Compliance with ethical standards

We confirm that the manuscript has been read and approved by all named authors and that there are no other persons who satisfied the criteria for authorship but are not listed. We also confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome.

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Chinese Center for Disease Control and PreventionInstitute for Environmental Health and Related Product SafetyBeijingChina
  2. 2.State Key Lab of Environmental Simulation and Pollution Control, College of Environmental Sciences and EngineeringPeking UniversityBeijingChina
  3. 3.Guangdong Institute of Public HealthGuangzhouChina

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