Environmental Science and Pollution Research

, Volume 22, Issue 10, pp 7705–7715 | Cite as

Comparison of essential and toxic elements in esophagus, lung, mouth and urinary bladder male cancer patients with related to controls

  • Tasneem Gul Kazi
  • Sham Kumar Wadhwa
  • Hassan Imran Afridi
  • Farah Naz Talpur
  • Mustafa Tuzen
  • Jameel Ahmed Baig
Research Article
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Abstract

There is a compelling evidence in support of negative associations between essential trace and toxic elements in different types of cancer. The aim of the present study was to investigate the relationship between carcinogenic (As, Cd, Ni) and anti-carcinogenic (Se, Zn) trace elements in scalp hair samples of different male cancerous patients (esophagus, lung, mouth, and urinary bladder). For comparative purposes, the scalp hair samples of healthy males of the same age group (ranged 35–65 years) as controls were analyzed. Both controls and patients have the same socioeconomic status, localities, dietary habits, and smoking locally made cigarette. The scalp hair samples were oxidized by 65 % nitric acid: 30 % hydrogen peroxide (2:1) ratio in microwave oven followed by atomic absorption spectrometry. The validity and accuracy of the methodology were checked using certified reference material of human hair BCR 397. The mean concentrations of As, Cd, and Ni were found to be significantly higher in scalp hair samples of patients having different cancers as compared to the controls, while reverse results were obtained in the case of Se and Zn levels (p < 0.01). The study revealed that the carcinogenic processes are significantly affecting the trace elements burden and mutual interaction of essential trace and toxic elements in the cancerous patients.

Keywords

Zinc Selenium Toxic elements Cancer Male Atomic absorption spectrophotometer 
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Supplementary material

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Tasneem Gul Kazi
    • 1
  • Sham Kumar Wadhwa
    • 1
  • Hassan Imran Afridi
    • 1
  • Farah Naz Talpur
    • 1
  • Mustafa Tuzen
    • 2
  • Jameel Ahmed Baig
    • 1
  1. 1.National Center of Excellence in Analytical ChemistryUniversity of SindhJamshoroPakistan
  2. 2.Faculty of Science and Arts, Chemistry DepartmentGaziosmanpasa UniversityTokatTurkey

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