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Environmental Science and Pollution Research

, Volume 21, Issue 19, pp 11361–11369 | Cite as

PCB153 and p,p′-DDE disorder thyroid hormones via thyroglobulin, deiodinase 2, transthyretin, hepatic enzymes and receptors

  • Changjiang Liu
  • Mei Ha
  • Lianbing Li
  • Kedi Yang
Research Article

Abstract

Polychlorinated biphenyls (PCBs) and DDT are widespread environmental persistent organic pollutants that have various adverse effects on reproduction, development and endocrine function. In order to elucidate effects of PCBs and DDT on thyroid hormone homeostasis, Sprague–Dawley rats were dosed with PCB153 and p,p′-DDE intraperitoneally (ip) for five consecutive days and sacrificed within 24 h after the last dose. Results indicated that after combined exposure to PCB153 and p,p′-DDE, total thyroxine , free thyroxine, total triiodothyronine, and thyroid-stimulating hormone in serum were decreased, whereas free triiodothyronine and thyrotropin-releasing hormone were not affected. Thyroglobulin and transthyretin levels in serum were significantly reduced. mRNA expression of deiodinases 2 (D2) was also suppressed, while D1 and D3 levels were not significantly influenced after combined exposure. PCB153 and p,p′-DDE induced hepatic enzymes, UDPGTs, CYP1A1, CYP2B1, and CYP3A1 mRNA expressions being significantly elevated. Moreover, TRα1, TRβ1, and TRHr expressions in the hypothalamus displayed increasing trends after combined exposure to PCB153 and p,p′-DDE. Taken together, observed results indicate that PCB153 and p,p′-DDE could disorder thyroid hormone homeostasis via thyroglobulin, deiodinase 2, transthyretin, hepatic enzymes, and hormone receptors.

Keywords

Thyroid hormone PCB153 p,p′-DDE Thyroglobulin Deiodinase Transthyretin Hepatic enzyme Hormone receptor 

Notes

Acknowledgments

This work is supported by grants from the National Natural Science Foundation of China (81172623).

Conflict of interest

No conflict of interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Changjiang Liu
    • 1
    • 2
  • Mei Ha
    • 3
  • Lianbing Li
    • 1
  • Kedi Yang
    • 2
  1. 1.Key Lab of Birth Defects and Reproductive Health of National Health and Family Planning CommissionChongqing Population and family planning Science and Technology Research InstituteChongqingPeople’s Republic of China
  2. 2.MOE Key Lab of Environment and Health, Department of Occupational and Environmental Health, School of Public Health, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanPeople’s Republic of China
  3. 3.Chongqing Three Gorges Medical CollegeChongqingPeople’s Republic of China

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