Environmental Science and Pollution Research

, Volume 20, Issue 12, pp 8567–8578 | Cite as

Fast determination of sulfonamides and their acetylated metabolites from environmental water based on magnetic molecularly imprinted polymers

  • Haiyan Chen
  • Yiqun Zhang
  • Bo Gao
  • Yang Xu
  • Qi Zhao
  • Juan Hou
  • Jin Yan
  • Guijie Li
  • Hui Wang
  • Lan Ding
  • Jie Ding
  • Chun Zhao
Research Article

Abstract

Group-selective magnetic molecularly imprinted polymers (MMIPs) that can extract four widely used sulfonamide antibiotics and their acetylated metabolites from environmental water were synthesized in this study. The MMIPs with saturation magnetization value of 16.7 emu g-1 could be separated from the environmental water samples easily by the application of an adscititious magnetic field, reducing the time consumption of pretreatment. The extraction conditions were evaluated, and optimal extraction conditions were as follows: extraction time, 25 min; amount of polymers, 90 mg; washing solvent, 30 % methanol aqueous solution; and elution solvent, methanol–acetic acid (95:5, v/v). The target analytes were detected by liquid chromatography–tandem mass spectrometry, and the detection limits of the method are in the range of 0.38–1.32 ng L-1. The relative standard deviations of intra- and inter-day are in the range of 1.3–6.8 % and 1.7–9.1 %, respectively. The proposed method is suitable for the analysis of environmental water samples.

Keywords

Sulfonamides Acetylated metabolites Environmental water Molecularly imprinted polymer Magnetic Scatchard analysis Matrix effect Liquid chromatography–tandem mass spectrometry 

Notes

Acknowledgments

The authors would like to thank the National Natural Science Fund of China (Grant No. 51078108), the Program for New Century Excellent Talents in University (Grant No. NCET-11-0795), and the Development Program of the Ministry of Science and Technology of Jilin Province (Grant No. 20120327) for their support in this study.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Haiyan Chen
    • 1
  • Yiqun Zhang
    • 1
  • Bo Gao
    • 2
    • 3
  • Yang Xu
    • 1
  • Qi Zhao
    • 1
  • Juan Hou
    • 1
  • Jin Yan
    • 1
  • Guijie Li
    • 1
  • Hui Wang
    • 1
  • Lan Ding
    • 1
  • Jie Ding
    • 4
  • Chun Zhao
    • 2
  1. 1.College of ChemistryJilin UniversityChangchunChina
  2. 2.Joint State Key Laboratory on Integrated OptoelectronicsJilin UniversityChangchunChina
  3. 3.College of Resources and Environmental SciencesJilin Agricultural UniversityChangchunChina
  4. 4.State Key Laboratory of Urban Water Resource and EnvironmentHarbin Institute of TechnologyHarbinChina

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