Environmental Science and Pollution Research

, Volume 20, Issue 7, pp 4933–4946 | Cite as

Adverse birth outcomes in the vicinity of industrial installations in Spain 2004–2008

  • Adela Castelló
  • Isabel Río
  • Javier García-Pérez
  • Pablo Fernández-Navarro
  • Lance A. Waller
  • Julie A. Clennon
  • Francisco Bolúmar
  • Gonzalo López-Abente
Research Article
First Online:
Received:
Accepted:

Abstract

Industrial activity is one of the main sources of ambient pollution in developed countries. However, research analyzing its effect on birth outcomes is inconclusive. We analyzed the association between proximity of mother’s municipality of residence to industries from 24 different activity groups and risk of very (VPTB) and moderate (MPTB) preterm birth, very (VLBW) and moderate (MLBW) low birth weight, and small for gestational age (SGA) in Spain, 2004–2008. An ecological study was defined, and a “near vs. far” analysis (3.5 km threshold) was carried out using Hierarchical Bayesian models implemented via Integrated Nested Laplace Approximation. VPTB risk was higher for mothers living near pharmaceutical companies. Proximity to galvanization and hazardous waste management industries increased the risk of MPTB. Risk of VLBW was higher for mothers residing near pharmaceutical and non-hazardous or animal waste management industries. For MLBW many associations were found, being notable the proximity to mining, biocides and animal waste management plants. The strongest association for SGA was found with proximity to management animal waste plants. These results highlight the importance of further research on the relationship between proximity to industrial sites and the occurrence of adverse birth outcomes especially for the case of pharmaceutical and animal waste management activities.

Keywords

Preterm Birth weight Gestational age Industrial pollution INLA Besag, York and Mollié 
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Notes

Acknowledgments

We would like to acknowledge the support of the Fondo de Investigación Sanitaria (PI081330), Spanish Ministry of Science and Innovation (SEJ 2005/07679 and CD11/00018), and the CIBER en Epidemiología y Salud Pública (CIBERESP), Spain.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Adela Castelló
    • 1
    • 5
  • Isabel Río
    • 1
  • Javier García-Pérez
    • 1
    • 2
  • Pablo Fernández-Navarro
    • 1
    • 2
  • Lance A. Waller
    • 3
  • Julie A. Clennon
    • 3
  • Francisco Bolúmar
    • 2
    • 4
  • Gonzalo López-Abente
    • 1
    • 2
  1. 1.National Center for EpidemiologyCarlos III Institute of HealthMadridSpain
  2. 2.CIBER en Epidemiología y Salud Pública (CIBERESP)BarcelonaSpain
  3. 3.Department of Biostatistics and Bioinformatics, Rollins School of Public HealthEmory UniversityAtlantaUSA
  4. 4.Department of Public Health Sciences, Faculty of MedicineUniversity of AlcaláAlcalá de Henares, MadridSpain
  5. 5.Instituto de Salud Carlos III, Centro Nacional de EpidemiologíaMadridSpain

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