Environmental Science and Pollution Research

, Volume 18, Issue 9, pp 1555–1566 | Cite as

Pharmaceuticals in the environment: an educational perspective

Research Article

Abstract

Purpose

Pharmaceuticals are an integral part of a dignified life. However, a lack of degradability and threats to the welfare of living beings cause concern due to their emission into the environment. There is also a lack of knowledge about cause and consequence. Therefore, we intend to contribute to the development of educational programmes which should increasingly include the topic ‘pharmaceuticals in the environment’.

Methods

Considering the current literature, we developed a corresponding series of worksheets (Online Resource) and sample solutions on an introductory level and integrated them into our curriculum.

Results

The material compiled for the worksheets was arranged in a logical order and considers several subtopics. The worksheets aim to support the examination of related aspects such as environmental effects, emissions, wastewater treatment plants, degradation, degradation by-products, advanced oxidation processes, hydraulic retention times, half-life times, biosolids, exposition pathways, precautionary principle, classification schemes for pharmaceuticals and, related to the structure–activity relationship, the design for degradability. The students managed to work on the tasks in an appropriate manner and received a good overview of the occurrence and fate of pharmaceuticals in the environment.

Conclusions

Tasks that were presented to students regarding the topic ‘pharmaceuticals in the environment’ contributed to a better understanding of the possible risks of medical care on an introductory level. The tasks have been incorporated into a logic series of worksheets (Online Resource) with sample solutions available. Alternatively, the material would be appropriate for the preparation of a corresponding lecture on this topic.

Keywords

Educational material Degradability Green pharmacy Water contamination Endocrine disruptors Mixtures Environmental risks Risk mitigation 

Abbreviations

WWTP

Wastewater treatment plant

Supplementary material

11356_2011_512_MOESM1_ESM.doc (2.4 mb)
Worksheets concerning the topic ‘Pharmaceuticals in the environment’ (DOC 2.40 mb)

References

  1. Aitken RJ, Koopman P, Lewis SEM (2004) Seeds of concern. Nature 432:48–52CrossRefGoogle Scholar
  2. Alfonsi K, Colberg J, Dunn PJ, Fevig T, Jennings S, Johnson TA, Kleine HP, Knight C, Nagy MA, Perry DA, Stefaniak M (2008) Green chemistry tools to influence a medicinal chemistry and research chemistry based organisation. Green Chem 10:31–36CrossRefGoogle Scholar
  3. Barrett JR (2009) The Yin and Yang of exposure: chemical combinations may explain feminization of wild fish. Environ Health Perspect 117:A210CrossRefGoogle Scholar
  4. Bedner M, MacCrehan WA (2005) Transformation of acetaminophen by chlorination produces the toxicants 1,4-benzoquinone and N-acetyl-p-benzoquinone imine. Environ Sci Technol 40:516–522CrossRefGoogle Scholar
  5. Boethling RS, Sommer E, DiFiore D (2007) Designing small molecules for biodegradability. Chem Rev 107:2207–2227CrossRefGoogle Scholar
  6. Bögershausen K, Parchmann I (1996) Denitrifikation von Trinkwasser Demonstration im Schulversuch. CHEMKON 3:187–189CrossRefGoogle Scholar
  7. Böschen S, Lenoir D, Scheringer M (2003) Sustainable chemistry: starting points and prospects. Naturwissenschaften 90:93–102Google Scholar
  8. Caliman FA, Gavrilescu M (2009) Pharmaceuticals, personal care products and endocrine disrupting agents in the environment—a review. Clean-Soil Air Water 37:277–303CrossRefGoogle Scholar
  9. Carvalho I, Borges ADL, Bernardes LSC (2005) Medicinal chemistry and molecular modeling: an integration to teach drug structure–activity relationship and the molecular basis of drug action. J Chem Educ 82:588–596CrossRefGoogle Scholar
  10. Castensson S, Eriksson V, Lindborg K, Br W (2009) A method to include the environmental hazard in drug prescribing. Pharm World Sci 31:24–31CrossRefGoogle Scholar
  11. Chen XB, Halasz SM, Giles EC, Mankus JV, Johnson JC, Burda C (2006) A simple parallel photochemical reactor for photodecomposition studies. J Chem Educ 83:265–267CrossRefGoogle Scholar
  12. Christen V, Hickmann S, Rechenberg B, Fent K (2010) Highly active human pharmaceuticals in aquatic systems: a concept for their identification based on their mode of action. Aquat Toxicol 96:167–181CrossRefGoogle Scholar
  13. Colucci MS, Topp E (2001) Persistence of estrogenic hormones in agricultural soils: II. 17 alpha-ethynylestradiol. J Environ Qual 30:2077–2080CrossRefGoogle Scholar
  14. Committee for Medicinal Products for Human Use (2006) Guideline on the environmental risk assessment of medicinal products for human use. Report no. EMEA/CHMP/SWP/4447/00. European Medicines Agency, London. http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/10/WC500003978.pdf. Accessed 7 Nov 2010
  15. Cooper ER, Siewicki TC, Phillips K (2008) Preliminary risk assessment database and risk ranking of pharmaceuticals in the environment. Sci Total Environ 398:26–33CrossRefGoogle Scholar
  16. Crane M, Watts C, Boucard T (2006) Chronic aquatic environmental risks from exposure to human pharmaceuticals. Sci Total Environ 367:23–41CrossRefGoogle Scholar
  17. Daughton CG (2003a) Cradle-to-cradle stewardship of drugs for minimizing their environmental disposition while promoting human health. I. Rationale for and avenues toward a green pharmacy. Environ Health Perspect 111:757–774CrossRefGoogle Scholar
  18. Daughton CG (2003b) Cradle-to-cradle stewardship of drugs for minimizing their environmental disposition while promoting human health. II. Drug disposal, waste reduction, and future directions. Environ Health Perspect 111:775–785CrossRefGoogle Scholar
  19. Daughton CG, Ternes TA (1999) Pharmaceuticals and personal care products in the environment: agents of subtle change? Environ Health Perspect 107:907–938CrossRefGoogle Scholar
  20. Deffner J, Götz K (2008) Handlungsoptionen für einen umweltfreundlicheren Umgang mit Arzneimitteln. Umweltwiss Schadst Forsch 20:238–248CrossRefGoogle Scholar
  21. Dhawale SW (1993) Introducing the treatment of waste and wastewater in the general chemistry course: applying physical and chemical principles to the problems of waste management. J Chem Educ 70:395–397CrossRefGoogle Scholar
  22. Dodd MC, Buffle M-O, von Gunten U (2006) Oxidation of antibacterial molecules by aqueous ozone: moiety-specific reaction kinetics and application to ozone-based wastewater treatment. Environ Sci Technol 40:1969–1977CrossRefGoogle Scholar
  23. Doerr-MacEwen NA, Haight ME (2006) Expert stakeholders’ views on the management of human pharmaceuticals in the environment. Environ Manage 38:853–866CrossRefGoogle Scholar
  24. Dorne J, Ragas AMJ, Frampton GK, Spurgeon DS, Lewis DF (2007a) Trends in human risk assessment of pharmaceuticals. Anal Bioanal Chem 387:1167–1172CrossRefGoogle Scholar
  25. Dorne J, Skinner L, Frampton G, Spurgeon D, Ragas A (2007b) Human and environmental risk assessment of pharmaceuticals: differences, similarities, lessons from toxicology. Anal Bioanal Chem 387:1259–1268CrossRefGoogle Scholar
  26. Eissen M, Metzger JO, Schmidt E, Schneidewind U (2002) 10 years after Rio—concepts on the contribution of chemistry to a sustainable development. Angew Chem Int Ed 41:414–436CrossRefGoogle Scholar
  27. Eissen M, Kaling S, Strudthoff M, Backhaus S, Eismann C, Oetken G, Lenoir D (2011) Oxidation numbers, oxidants, and redox reactions: variants of the electrophilic bromination of alkenes and variants of the application of oxone. J Chem Educ 88:284–291CrossRefGoogle Scholar
  28. European Parliament (2004) Directive 2004/27/EC of the European Parliament and of the Council of 31 March 2004 amending Directive 2001/83/EC on the Community code relating to medicinal products for human use. European Parliament, Strasbourg. http://ec.europa.eu/enterprise/pharmaceuticals/eudralex/vol-1/dir_2004_27/dir_2004_27_en.pdf; in German: http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2004:136:0034:0057:DE:PDF. Accessed 12 Mar 2009
  29. Evans AL, Messersmith RE, Green DB, Fritsch JM (2011) Degradation of environmental contaminants with water-soluble cobalt catalysts: an integrative inorganic chemistry investigation. J Chem Educ 88:204–208CrossRefGoogle Scholar
  30. Federsel HJ (2006) In search of sustainability: process R&D in light of current pharmaceutical industry challenges. Drug Discov Today 11:966–974CrossRefGoogle Scholar
  31. Fent K, Weston AA, Caminada D (2006) Ecotoxicology of human pharmaceuticals. Aquat Toxicol 76:122–159CrossRefGoogle Scholar
  32. Fick J, Lindberg RH, Tysklind M, Haemig PD, Waldenström J, Wallensten A, Olsen B (2007) Antiviral oseltamivir is not removed or degraded in normal sewage water treatment: implications for development of resistance by influenza A virus. PLoS ONE 2:1–5CrossRefGoogle Scholar
  33. Ginebreda A, Muñoz I, de Alda ML, Brix R, López-Doval J, Barceló D (2010) Environmental risk assessment of pharmaceuticals in rivers: relationships between hazard indexes and aquatic macroinvertebrate diversity indexes in the Llobregat River (NE Spain). Environ Int 36:153–162CrossRefGoogle Scholar
  34. Grguric G (2002) Denitrification as a model chemical process. J Chem Educ 79:179–182CrossRefGoogle Scholar
  35. Gros M (2010, personal communication) Personal communication with Meritxell Gros allowed us to identify two errors in Table 3 of the reference [Gros M, Petrovic M, Barceló D (2007) Wastewater treatment plants as a pathway for aquatic contamination by pharmaceuticals in the Ebro river basin (Northeast Spain). Environ. Toxicol. Chem. 26:1553–1562]. (1) Table 3, WWTP2: analgesics and anti-inflammatories in influent wastewaters were 0.3 g/day/1000 inhabitants instead of 1.60 g/day/1000 inhabitants. (2) Measuring results being noted below “WWTP3” have to change the place with those being noted below “WWTP2”. A correct presentation of the total loads is illustrated with Figure 1 in reference [Petrovic M, de Alda MJL, Diaz-Cruz S, Postigo C, Radjenovic J, Gros M, Barcelo D (2009) Fate and removal of pharmaceuticals and illicit drugs in conventional and membrane bioreactor wastewater treatment plants and by riverbank filtration. Philos. Trans. R. Soc. London, Ser. A 367:3979–4003]Google Scholar
  36. Gros M, Petrovic M, Barceló D (2007) Wastewater treatment plants as a pathway for aquatic contamination by pharmaceuticals in the Ebro river basin (Northeast Spain). Environ Toxicol Chem 26:1553–1562CrossRefGoogle Scholar
  37. Gros M, Petrovic M, Ginebreda A, Barceló D (2010) Removal of pharmaceuticals during wastewater treatment and environmental risk assessment using hazard indexes. Environ Int 36:15–26CrossRefGoogle Scholar
  38. Gunnarsson B, Wennmalm Å (2006) Environmental risk assessment and environmental classification of drugs. In: Bengtsson B-E, Gunnarsson B, Wall T, Wennmalm Å (eds) Environment and pharmaceuticals. Apoteket AB (The National Corporation of Swedish Pharmacies), Stockholm County Council and Stockholm University, pp 117–125. http://www.janusinfo.se/Global/Miljo_och_lakemedel/lakemed_miljo_eng2007.pdf. Accessed 26 Mar 2011
  39. Hansmann R, Mieg HA, Frischknecht PM (2010) Qualifications for contributing to sustainable development. A survey of environmental sciences graduates. Gaia-Ecol Perspect Sci Soc 19:278–286Google Scholar
  40. Harremoës P, Gee D, MacGarvin M, Stirling A, Keys J, Wynne B, Guedes Vaz S (2002) Late lessons from early warnings: the precautionary principle 1896–2000. OPOCE (Office for Official Publications of the European Communities), Copenhagen. http://www.eea.europa.eu/publications/environmental_issue_report_2001_22; in German: http://www.umweltdaten.de/publikationen/fpdf-l/2697.pdf. Accessed 2 May 2011Google Scholar
  41. Heberer T (2002) Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Toxicol Lett 131:5–17CrossRefGoogle Scholar
  42. Hernandez MA, Czerwinska J (2008) A web-based interactive module to teach acid–base principles of drug action. J Chem Educ 85:1704CrossRefGoogle Scholar
  43. Hernando MD, Fernández-Alba AR, Tauler R, Barceló D (2005) Toxicity assays applied to wastewater treatment. Talanta 65:358–366CrossRefGoogle Scholar
  44. Hickman RJS, Neill J (1997) Influence of pH on drug absorption from the gastrointestinal tract—a simple chemical model. J Chem Educ 74:855–856CrossRefGoogle Scholar
  45. Huber MM, Göbel A, Joss A, Hermann N, Löffler D, McArdell CS, Ried A, Siegrist H, Ternes TA, von Gunten U (2005) Oxidation of pharmaceuticals during ozonation of municipal wastewater effluents: a pilot study. Environ Sci Technol 39:4290–4299CrossRefGoogle Scholar
  46. Hutchinson TH, Beesley A, Frickers PE, Readman JW, Shaw JP, Straub JO (2009) Extending the environmental risk assessment for oseltamivir (Tamiflu (R)) under pandemic use conditions to the coastal marine compartment. Environ Int 35:931–936CrossRefGoogle Scholar
  47. Institute for Social-Ecological Research GmbH (2008) Start: management strategies for pharmaceutical residues in drinking water—pharmaceuticals for human use: options of action for reducing the contamination of water bodies—a practical guide. http://www.start-project.de/downloads/start_Practical_Guide.pdf (in German: http://www.start-project.de/downloads/start.pdf). Accessed 29 Jan 2010
  48. Jacobsen EK (2004) Water filtration. J Chem Educ 81:224AGoogle Scholar
  49. Jones-Lepp TL, Stevens R (2007) Pharmaceuticals and personal care products in biosolids/sewage sludge: the interface between analytical chemistry and regulation. Anal Bioanal Chem 387:1173–1183CrossRefGoogle Scholar
  50. Keil F, Bechmann G, Kümmerer K, Schramm E (2008) Systemic risk governance for pharmaceutical residues in drinking water. GAIA - Ecol Perspect Sci Soc 17:355–361Google Scholar
  51. Khetan SK, Collins TJ (2007) Human pharmaceuticals in the aquatic environment: a challenge to green chemistry. Chem Rev 107:2319–2364CrossRefGoogle Scholar
  52. Kidd KA, Blanchfield PJ, Mills KH, Palace VP, Evans RE, Lazorchak JM, Flick RW (2007) Collapse of a fish population after exposure to a synthetic estrogen. P Natl Acad Sci USA 104:8897–8901CrossRefGoogle Scholar
  53. Kümmerer K (2007) Sustainable from the very beginning: rational design of molecules by life cycle engineering as an important approach for green pharmacy and green chemistry. Green Chem 9:899–907CrossRefGoogle Scholar
  54. Kümmerer K (2009) The presence of pharmaceuticals in the environment due to human use—present knowledge and future challenges. J Environ Manage 90:2354–2366CrossRefGoogle Scholar
  55. Kümmerer K, Schramm E (2008) Arzneimittelentwicklung: Die Reduzierung von Umweltbelastungen durch gezieltes Moleküldesign. Umweltwiss Schadst Forsch 20:249–263CrossRefGoogle Scholar
  56. Längin A, Schuster A, Kümmerer K (2008) Chemicals in the environment—the need for a clear nomenclature: parent compounds, metabolites, transformation products and their elimination. CLEAN - Soil, Air, Water 36:349–350CrossRefGoogle Scholar
  57. Lubick N (2008) Opening the “green pharmacy”. Environ Sci Technol 42:8620–8621CrossRefGoogle Scholar
  58. Luehrs DC, Roher AE (2007) Demonstration of the Fenton reaction. J Chem Educ 84:1290–1291CrossRefGoogle Scholar
  59. Lund T (1999–2004) Working Document 21.06.2000, Endocrine disrupting substances—background paper, European Parliament, Committee on the Environment, Public Health and Consumer Policy. http://www.europarl.europa.eu/meetdocs/committees/envi/20000710/413253_en.doc. Accessed 10 Jan 2010
  60. Lundgren A (2006) Assessment in the chemicals control of environmental hazards and risks. In: Bengtsson B-E, Gunnarsson B, Wall T, Wennmalm Å (eds) Environment and Pharmaceuticals. Apoteket AB (The National Corporation of Swedish Pharmacies), Stockholm County Council and Stockholm University, 105–115, pp 117–125. http://www.janusinfo.se/Global/Miljo_och_lakemedel/lakemed_miljo_eng2007.pdf. Accessed 26 Mar 2011
  61. Mailhot G, Sarakha M, Lavedrine B, Cáceres J, Malato S (2002) Fe(III)-solar light induced degradation of diethyl phthalate (DEP) in aqueous solutions. Chemosphere 49:525–532CrossRefGoogle Scholar
  62. Marks R, Eilks I (2010) Research-based development of a lesson plan on shower gels and musk fragrances following a socio-critical and problem-oriented approach to chemistry teaching. Chem Educ Res Pract 11:129–141CrossRefGoogle Scholar
  63. McDowell DC, Huber MM, Wagner M, von Gunten U, Ternes TA (2005) Ozonation of carbamazepine in drinking water: identification and kinetic study of major oxidation products. Environ Sci Technol 39:8014–8022CrossRefGoogle Scholar
  64. Miles WH, Smiley PM (2002) Modeling the drug discovery process: the isolation and biological testing of eugenol from clove oil. J Chem Educ 79:90CrossRefGoogle Scholar
  65. Monteiro SC, Boxall ABA (2010) Occurrence and fate of human pharmaceuticals in the environment. In: Whitacre DM (ed) Reviews of environmental contamination and toxicology, vol 202. Springer, New York, pp 53–154, <Go to ISI>://000272540400002CrossRefGoogle Scholar
  66. Nash JJ, Meyer JAR, Nurrenbern SC (1996) Waste treatment in the undergraduate laboratory: let the students do it! J Chem Educ 73:1183–1185CrossRefGoogle Scholar
  67. Nikolaou A, Meric S, Fatta D (2007) Occurrence patterns of pharmaceuticals in water and wastewater environments. Anal Bioanal Chem 387:1225–1234CrossRefGoogle Scholar
  68. Oaks JL, Gilbert M, Virani MZ, Watson RT, Meteyer CU, Rideout BA, Shivaprasad HL, Ahmed S, Iqbal Chaudhry MJ, Arshad M, Mahmood S, Ali A, Ahmed Khan A (2004) Diclofenac residues as the cause of vulture population decline in Pakistan. Nature 427:630–633CrossRefGoogle Scholar
  69. Pain DJ, Bowden CGR, Cunningham AA, Cuthbert R, Das D, Gilbert M, Jakati RD, Jhala Y, Khan AA, Naidoo V, Oaks JL, Parry-Jones J, Prakash V, Rahman A, Ranade SP, Baral HS, Senacha KR, Saravanan S, Shah N, Swan G, Swarup D, Taggart MA, Watson RT, Virani MZ, Wolter K, Green RE (2008) The race to prevent the extinction of South Asian vultures. Bird Conserv Int 18:S30–S48CrossRefGoogle Scholar
  70. Petrovic M, de Alda MJL, Diaz-Cruz S, Postigo C, Radjenovic J, Gros M, Barcelo D (2009) Fate and removal of pharmaceuticals and illicit drugs in conventional and membrane bioreactor wastewater treatment plants and by riverbank filtration. Philos Trans R Soc Lond A 367:3979–4003CrossRefGoogle Scholar
  71. Pomati F, Orlandi C, Clerici M, Luciani F, Zuccato E (2008) Effects and interactions in an environmentally relevant mixture of pharmaceuticals. Toxicol Sci 102:129–137CrossRefGoogle Scholar
  72. Prasse C, Schlüsener MP, Schulz R, Ternes TA (2010) Antiviral drugs in wastewater and surface waters: a new pharmaceutical class of environmental relevance? Environ Sci Technol 44:1728–1735CrossRefGoogle Scholar
  73. Price LB, Johnson E, Vailes R, Silbergeld E (2005) Fluoroquinolone-resistant Campylobacter isolates from conventional and antibiotic-free chicken products. Environ Health Perspect 113:557–560CrossRefGoogle Scholar
  74. Price LB, Lackey LG, Vailes R, Silbergeld E (2007) The persistence of fluoroquinolone-resistant Campylobacter in poultry production. Environ Health Perspect 115:1035–1039CrossRefGoogle Scholar
  75. Prüße U, Vorlop K-D (1996) Entfernung von Nitrat aus Trinkwasser. CHEMKON 3:62–67CrossRefGoogle Scholar
  76. Radke M (2010) Personal communication: the data demonstrated in the worksheet table were provided by Michael RadkeGoogle Scholar
  77. Radke M, Lauwigi C, Heinkele G, Mürdter TE, Letzel M (2009) Fate of the antibiotic sulfamethoxazole and its two major human metabolites in a water sediment test. Environ Sci Technol 43:3135–3141CrossRefGoogle Scholar
  78. Rieger PG, Meier HM, Gerle M, Vogt U, Groth T, Knackmuss HJ (2002) Xenobiotics in the environment: present and future strategies to obviate the problem of biological persistence. J Biotechnol 94:101–123CrossRefGoogle Scholar
  79. Ruzickova P, Holoubek I, Klanova J (2006) Experimental studies of environmental processes: a practical course in environmental chemistry. Environ Sci Pollut Res 13:435–440CrossRefGoogle Scholar
  80. Santos LHMLM, Araújo AN, Fachini A, Pena A, Delerue-Matos C, Montenegro MCBSM (2010) Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment. J Hazard Mater 175:45–95CrossRefGoogle Scholar
  81. Schäfer AI, Beder S (2006) Relevance of the precautionary principle in water recycling. Desalination 187:241–252CrossRefGoogle Scholar
  82. Segura PA, Francois M, Gagnon C, Sauve S (2009) Review of the occurrence of anti-infectives in contaminated wastewaters and natural and drinking waters. Environ Health Perspect 117:675–684CrossRefGoogle Scholar
  83. Shearouse WC, Waddell DC, Mack J (2009) Alternative solvent-free methodologies in the synthesis of pharmaceutical drugs. Curr Opin Drug Discov Dev 12:772–783Google Scholar
  84. Singer AC, Nunn MA, Gould EA, Johnson AC (2007) Potential risks associated with the proposed widespread use of Tamiflu. Environ Health Perspect 115:102–106CrossRefGoogle Scholar
  85. Singer AC, Howard BM, Johnson AC, Knowles CJ, Jackman S, Accinelli C, Caracciolo AB, Bernard I, Bird S, Boucard T, Boxall A, Brian JV, Cartmell E, Chubb C, Churchley J, Costigan S, Crane M, Dempsey MJ, Dorrington B, Ellor B, Fick J, Holmes J, Hutchinson T, Karcher F, Kelleher SL, Marsden P, Noone G, Nunn MA, Oxford J, Rachwal T, Roberts N, Roberts M, Sacca ML, Sanders M, Straub JO, Terry A, Thomas D, Toovey S, Townsend R, Vouivoulis N, Watts C (2008) Meeting report: risk assessment of tamiflu use under pandemic conditions. Environ Health Perspect 116:1563–1567CrossRefGoogle Scholar
  86. Smith DK (2005) A supramolecular approach to medicinal chemistry: medicine beyond the molecule. J Chem Educ 82:393–400CrossRefGoogle Scholar
  87. Smith SR (2009) Organic contaminants in sewage sludge (biosolids) and their significance for agricultural recycling. Philos Trans R Soc Lond A 367:4005–4041CrossRefGoogle Scholar
  88. Stabile RG, Dicks AP (2003) Microscale synthesis and spectroscopic analysis of flutamide, an antiandrogen prostate cancer drug. J Chem Educ 80:1439–1443CrossRefGoogle Scholar
  89. Stachulski AV, Lennard MS (2000) Drug metabolism: the body's defense against chemical attack. J Chem Educ 77:349–353CrossRefGoogle Scholar
  90. Stockholm County Council (2011) Environmentally Classified Pharmaceuticals, Stockholm. http://www.janusinfo.se/Global/Miljo_och_lakemedel/miljobroschyr_2011_uppslag_eng.pdf. Accessed 2 May 2011
  91. Straub JO (2009) An environmental risk assessment for oseltamivir (Tamiflu (R)) for sewage works and surface waters under seasonal-influenza- and pandemic-use conditions. Ecotoxicol Environ Saf 72:1625–1634CrossRefGoogle Scholar
  92. Stumpe B, Marschner B (2009) Factors controlling the biodegradation of 17[beta]-estradiol, estrone and 17[alpha]-ethinylestradiol in different natural soils. Chemosphere 74:556–562CrossRefGoogle Scholar
  93. Sumpter JP (2009) Protecting aquatic organisms from chemicals: the harsh realities. Philos Trans R Soc Lond A 367:3877–3894CrossRefGoogle Scholar
  94. Taggart MA, Senacha KR, Green RE, Jhala YV, Raghavan B, Rahmani AR, Cuthbert R, Pain DJ, Meharg AA (2007) Diclofenac residues in carcasses of domestic ungulates available to vultures in India. Environ Int 33:759–765CrossRefGoogle Scholar
  95. Tatarko M, Tricker J, Andrzejewski K, Bumpus JA, Rhoads H (1999) Remediation of water contaminated with an azo dye: an undergraduate laboratory experiment utilizing an inexpensive photocatalytic reactor. J Chem Educ 76:1680CrossRefGoogle Scholar
  96. Ternes TA, Meisenheimer M, McDowell D, Sacher F, Brauch H-J, Haist-Gulde B, Preuss G, Wilme U, Zulei-Seibert N (2002) Removal of pharmaceuticals during drinking water treatment. Environ Sci Technol 36:3855–3863CrossRefGoogle Scholar
  97. Tsai CS (2007) Using computer applications and online resources to teach and learn pharmaceutical chemistry. J Chem Educ 84:2019–2023CrossRefGoogle Scholar
  98. United Nations (1992) a) Rio Declaration on Environment and Development; b) Agenda 21, United Nations Conference on Environment and Development, Rio de Janeiro. http://www.un.org/esa/sustdev. Accessed 10 Jul 2008
  99. Vedani A, Schwardt O, Rabbani S, Ernst B (2006) A thorough training in Modem Drug Design. Chimia 60:70–75CrossRefGoogle Scholar
  100. Velagaleti R, Burns PK, Gill M, Prothro J (2002) Impact of current good manufacturing practices and emission regulations and guidances on the discharge of pharmaceutical chemicals into the environment from manufacturing, use, and disposal. Environ Health Perspect 110:213–220CrossRefGoogle Scholar
  101. Voutchkova AM, Osimitz TG, Anastas PT (2010) Toward a comprehensive molecular design framework for reduced hazard. Chem Rev 110:5845–5882CrossRefGoogle Scholar
  102. Wennmalm A, Gunnarsson B (2009) Pharmaceutical management through environmental product labeling in Sweden. Environ Int 35:775–777CrossRefGoogle Scholar
  103. Yu JC, Chan LYL (1998) Photocatalytic degradation of a gaseous organic pollutant. J Chem Educ 75:750–751CrossRefGoogle Scholar
  104. Yuriev E, Chalmers D, Capuano B (2009) Conformational analysis of drug molecules: a practical exercise in the medicinal chemistry course. J Chem Educ 86:477–478CrossRefGoogle Scholar
  105. Zwiener C (2007) Occurrence and analysis of pharmaceuticals and their transformation products in drinking water treatment. Anal Bioanal Chem 387:1159–1162CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  1. 1.Gymnasium GanderkeseeGanderkeseeGermany

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