Winter accumulation of acidic pharmaceuticals in a Swedish river
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In this study, seasonal variations in the concentration profile of four analgesics and one lipid regulator were monitored on their way from a wastewater treatment plant (WWTP) effluent, along a river, and into a lake.
From December 2007 to December 2008, water samples were collected monthly (n = 12) from an upstream point, the effluent, four downstream points of the WWTP, and at the point where the river merges with the lake, and the concentrations of ibuprofen, naproxen, bezafibrate, diclofenac, and ketoprofen were determined. The analytical methodology involved solid-phase extraction of the target compounds from water samples followed by liquid chromatography coupled with tandem mass spectrometry for compound separation and detection.
The studied pharmaceuticals were found in the effluent at concentrations ranging from 31 to 1,852 ng l−1 depending on the season. In the river and lake, the concentrations were much lower (6–400 ng l−1) mainly due to dilution but also to a season-dependent contribution from natural transformation processes. The mean mass flow of all analgesics was highest during winter while the highest mean mass flow of the lipid regulator bezafibrate was observed in spring.
The WWTP is the main source of the target compounds in the aquatic environment. The observed winter accumulation signifies the importance of natural transformation processes, which can only be estimated based on mass flow data, on the fate of pharmaceuticals in the environment.
KeywordsWinter Pharmaceutical WWTP River Sweden
The authors would like to thank The Swedish Research Council for Environment, Agricultural Sciences, and Spatial Planning (Formas) for financial support of this project. Dr. Jerker Fick is acknowledged for contributing in the early planning of this project and providing the internal standards. Professor Michèle Prévost is also greatly thanked for reviewing the manuscript and her helpful comments.
- Castiglioni S, Bagnati R, Calamari D, Fanelli R, Zuccato E (2005) A multiresidue analytical method using solid-phase extraction and high-pressure liquid chromatography tandem mass spectrometry to measure pharmaceuticals of different therapeutic classes in urban wastewaters. J Chromatog A 1092:206–215CrossRefGoogle Scholar
- Loos R, Wollgast J, Huber T, Hanke G (2007) Polar herbicides, pharmaceutical products, perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), and nonylphenol and its carboxylates and ethoxylates in surface and tap waters around Lake Maggiore in northern Italy. Anal Bioanal Chem 387:1469–1478CrossRefGoogle Scholar
- Pharma Professional Service (2009) http://www.phaps.com. Accessed 1 July 2009
- SRC PhysProp Database (2009) Interactive PhysProp Database Demo. http://esc.syrres.com/interkow/physsdemo.htm. Accessed 01 July 2009
- Vieno N (2006) Occurrence of pharmaceuticals in Finnish sewage treatment plants, surface waters, and their elimination in drinking water treatment processes. Dissertation, Tampere University of TechnologyGoogle Scholar
- Viglino L, Aboulfadl K, Daneshvar Mahvelat A, Prévost M, Sauvé S (2008) On-line solid phase extraction and liquid chromatography/tandem mass spectrometry to quantify pharmaceuticals, pesticides and some metabolites in wastewaters, drinking, and surface waters. J Environ Monitor 10:482–489CrossRefGoogle Scholar