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Sport Sciences for Health

, Volume 15, Issue 1, pp 249–253 | Cite as

Restoring knee joint kinematics after anterior cruciate ligament injury might inhibit synovial membrane inflammation

  • Kenji MurataEmail author
  • Takanori Kokubun
  • Kiyomi Takayanagi
  • Naohiko Kanemura
Short Communication
  • 19 Downloads

Abstract

We developed a novel controlled abnormal joint movement (CAJM) model that controls instability after traditional anterior cruciate ligament transection (ACL-T). We evaluated whether joint instability damping suppresses synovial inflammation in osteoarthritis patients using our new CAJM rat model. We found that joint instability in rats differed between the ACL-T and CAJM models. Joint instability might contribute to synovitis and inhibit osteoarthritis.

Keywords

Joint kinematics Synovitis Knee Rat model 

Abbreviations

OA

Osteoarthritis

ACL

Anterior cruciate ligament

ACL-T

ACL transection

CAJM

Controlled abnormal joint movement

MMP

Matrix metalloproteinase

ADAMTs

A disintegrin and metalloproteinase with thrombospondin motifs

Notes

Acknowledgements

We would like to thank Kassuya Onitsuka (Tokyo Women’s Medical University, Yachiyo Medical Center), Namine Kiso (Saitama Sekishinkai Hospital), Yoko Sirose (Yokohama Rosai Hospital), and Nozomi Kuwabara (Graduate School of Saitama Prefectural University) for their assistance with the surgery and sample collection. This study was supported by a JSPS KAKENHI (26560278) Grant in-Aid for Challenging Exploratory Research.

Funding

This study was funded by a JSPS KAKENHI (26560278) Grant in-Aid for Challenging Exploratory Research.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.

Ethical approval

The Ethics Committee of Saitama Prefectural University approved all procedures (approval number: 27-6). All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

Informed consent

Informed consent is not applicable for this study.

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Copyright information

© Springer-Verlag Italia S.r.l., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Physical Therapy, School of Health and Social ServicesSaitama Prefectural UniversityKoshigayaJapan

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