Restoring knee joint kinematics after anterior cruciate ligament injury might inhibit synovial membrane inflammation
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We developed a novel controlled abnormal joint movement (CAJM) model that controls instability after traditional anterior cruciate ligament transection (ACL-T). We evaluated whether joint instability damping suppresses synovial inflammation in osteoarthritis patients using our new CAJM rat model. We found that joint instability in rats differed between the ACL-T and CAJM models. Joint instability might contribute to synovitis and inhibit osteoarthritis.
KeywordsJoint kinematics Synovitis Knee Rat model
Anterior cruciate ligament
Controlled abnormal joint movement
A disintegrin and metalloproteinase with thrombospondin motifs
We would like to thank Kassuya Onitsuka (Tokyo Women’s Medical University, Yachiyo Medical Center), Namine Kiso (Saitama Sekishinkai Hospital), Yoko Sirose (Yokohama Rosai Hospital), and Nozomi Kuwabara (Graduate School of Saitama Prefectural University) for their assistance with the surgery and sample collection. This study was supported by a JSPS KAKENHI (26560278) Grant in-Aid for Challenging Exploratory Research.
This study was funded by a JSPS KAKENHI (26560278) Grant in-Aid for Challenging Exploratory Research.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflicts of interest.
The Ethics Committee of Saitama Prefectural University approved all procedures (approval number: 27-6). All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.
Informed consent is not applicable for this study.
- 2.Kokubun T, Kanemura N, Murata K, Moriyama H, Morita S, Jinno T, Ihara H, Takayanagi K (2016) Effect of changing the joint kinematics of knees with a ruptured anterior cruciate ligament on the molecular biological responses and spontaneous healing in a rat model. Am J Sports Med 44:2900–2910CrossRefGoogle Scholar