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Acute effects of aerobic and resistance exercises on serum leptin and risk factors for coronary heart disease in obese females

  • F. Rahmani-nia
  • N. RahnamaEmail author
  • Z. Hojjati
  • B. Soltani
Original Article

Abstract

Six young obese females (20.5±1.22 years; BMI=34.5±4.3 kg/m2) participated in a resistance exercise (RE) protocol (12 exercises, 4 sets × 15 repetitions at 60% of 1RM), an aerobic exercise (AE) protocol (3 sets × 10 min ergometer cycling at 60% of maximal heart rate with 5 min of rest between sets), and a control session. Blood samples were collected before, and immediately after and 10 h after exercise. All protocols were done in follicular phase of the menstrual cycle. ANOVA (3×3) with repeated measure on exercise (3 levels) and time (3 levels) factors was used to determine the effects of exercise protocol, time and exercise protocol by blood sampling time interaction, triglycerides, HDL-cholesterol, LDL-cholesterol, and glucose concentrations. Immediately and 10 h after AE, serum leptin was significantly lower (p<0.05). Serum insulin after AE was lower than after RE and control sessions (p<0.05). Furthermore, no significant differences were found in serum leptin and insulin between RE and control sessions immediately after and 10 h after exercise. Blood glucose, triglycerides, total cholesterol, HDL-cholesterol and LDL-cholesterol were unchanged in both exercise protocols. In conclusion, AE resulted in a serum leptin reduction and suppressed the circadian rhythm of serum insulin when sampled immediately and 10 h after exercise; instread, RE did not result in serum leptin or insulin changes.

Key words

Obesity Leptin Exercise Coronary heart disease 

References

  1. 1.
    Mokdad AH, Ford ES, Bowman BA et al (2003) Prevalence of obesity, diabetes and obesity-related health risk factors, 2001. JAMA 289:76–79PubMedCrossRefGoogle Scholar
  2. 2.
    Cooke JP, Oka RK (2002) Does leptin cause vascular disease? Circulation 106:1904–1905PubMedCrossRefGoogle Scholar
  3. 3.
    Krauss RM, Winston M, Flecher BJ, Grundy SM (1998) Obesity: impact on cardiovascular disease. Circulation 98:10–16Google Scholar
  4. 4.
    Ronti T, Lupattelli G, Mannarino E (2006) The endocrine function of adipose tissue: an update. Clin Endocrinol 64(4):355–365Google Scholar
  5. 5.
    Kraemer KK, Chu H, Castracane VD, (2002) Leptin and exercise. Exp Biol Med 227:701–708Google Scholar
  6. 6.
    Zhang Y, Proenca R, Maffei M et al (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 373:425–432CrossRefGoogle Scholar
  7. 7.
    Thong FSL, Hudson R, Ross R et al (2000) Plasma leptin in moderately obese males: independent effects of weight loss and aerobic exercise. Am J Physiol Endocrinol Metab 279:E307–E313PubMedGoogle Scholar
  8. 8.
    Barbato KB, Martins Rde C, Rodrigues Mde L et al (2006) Effects of greater-than-5% weight reduction on hemodynamic, metabolic and neuroendocrine profiles of grade 1 obese subjects. Arq Bras Cardiol 87:12–21 (article in Portuguese)PubMedCrossRefGoogle Scholar
  9. 9.
    Hilton LK, Loucks AB (2000) Low energy availability, not exercise stress, suppresses the diurnal rhythm of leptin in healthy young women. Am J Physiol Endocrinol Metab 278:E43–E49PubMedGoogle Scholar
  10. 10.
    Houmard JA, Cox JH, Maclean PS, Barakat HA (2000) Effect of short-term exercise training on leptin and insulin action. Metabolism 49:858–861PubMedCrossRefGoogle Scholar
  11. 11.
    Livshits G, Pantsulaia I, Gerber LM (2005) Association of leptin levels with obesity and blood pressure: possible common genetic variation. Int J Obes 29:85–92CrossRefGoogle Scholar
  12. 12.
    Fenkci S, Sarsan A, Rota S, Ardic F (2006) Effects of resistance or aerobic exercises on metabolic parameters in obese women who are not on a diet. Adv Ther 23:404–413PubMedCrossRefGoogle Scholar
  13. 13.
    Konstantinides S, Schafer K, Koschnick S, Loskutoff DJ (2001) Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombitic disease in obesity. J Clin Invest 108:1533–1540PubMedGoogle Scholar
  14. 14.
    Mendosa-Nunez VM, Garcia-Sanchez A, Sanchez-Rodriguez M et al (2002) Overweight, waist circumference, age, gender, and insulin resistance as risk factors for hyperleptinemia. Obes Res 10:253–259CrossRefGoogle Scholar
  15. 15.
    Franklin SS (2005) Arterial stiffness and hypertension: a two way street? Hypertension 45:349–355PubMedCrossRefGoogle Scholar
  16. 16.
    Rahmouni K, Haynes WG (2004) Leptin and the cardiovascular system. Recent Progr Hormone Res 59:224–244Google Scholar
  17. 17.
    Altman R (2003) Risk factors in coronary atherosclerosis atheroinflamation: the meeting point. Thrombosis J 1:4–7CrossRefGoogle Scholar
  18. 18.
    Canavan B, Salem RO, Schurgin PK et al (2005) Effect of physiological leptin administration on markers of inflammation, platelet activation, and platelet aggregation during caloric deprivation. J Clin Endocrinol Metab 90(10):5779–5785PubMedCrossRefGoogle Scholar
  19. 19.
    Singhal A, Farooqi IS, Cole TJ et al J (2002) Influence of leptin on arterial distensibility: a novel link between obesity and cardiovascular disease? Circulation 106:1919–1926PubMedCrossRefGoogle Scholar
  20. 20.
    Wallace AM, McMahon AD, Packard CJ et al (2001) Plasma leptin and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS). Circulation 104:3052–3060PubMedCrossRefGoogle Scholar
  21. 21.
    Bouassida A, Zalleg D, Bouassida S et al (2006) Leptin, its implication in physical exercise and training: a short review. J Sport Science Med 5:172–181Google Scholar
  22. 22.
    McGill HC, McMahan A, Hederick EE et al (2002) Obesity accelerates the progression of coronary atherosclerosis in young men. Circulation 105:2712–2717PubMedCrossRefGoogle Scholar
  23. 23.
    Zafeiridis A, Smilios I, Conisidine V, Tokmakidis SP (2003) Serum responses after acute resistance exercise protocols. J Appl Physiol 94:591–597PubMedGoogle Scholar
  24. 24.
    Hickey MS, Considine RV, Israel RG (1996) Leptin is related to body fat content in male distance runners. Am J Physiol 271:E938–E940PubMedGoogle Scholar
  25. 25.
    Pasman WJ, Westerterp-Plantegna MS, Saris WHM (1998) The effect of exercise training on plasma leptin levels in obese male. Am J Physiol 274:E280–E286PubMedGoogle Scholar
  26. 26.
    Perusse L, Collier G, Gognon J et al (1997) Acute and chronic effects of exercise on leptin levels in humans. J Appl Physiol 83:5–10PubMedGoogle Scholar
  27. 27.
    Ryan AS, Praley RE, Goldberg AP (2000) Changes in plasma leptin and insulin action with resistive training in postmenopausal females. Int J Obes Rel Metab Disord 24:27–32CrossRefGoogle Scholar
  28. 28.
    Racette SB, Coppack SW, Landt M, Klein S (1997) Leptin production during moderate-intensity aerobic exercise. J Clin Endocrinol Metab 82:2275–2277PubMedCrossRefGoogle Scholar
  29. 29.
    Weltman A, Pritzlaff CJ, Wideman L et al (2000) Intensity of acute exercise dese not affect serum leptin concentrations in young males. Med Sci Sports Exercise 32:1556–1561CrossRefGoogle Scholar
  30. 30.
    Ishii T, Yamakita T, Yamagami K et al (2001) Effects of exercise training on serum leptin levels in type 2 diabetic patients. Metabolism 50:1136–1140PubMedCrossRefGoogle Scholar
  31. 31.
    Nindl BC, Kreamer WJ, Arciero PJ et al (2002) Leptin concentrations experience a delayed reduction after resistance exercise in men. Med Sci Sport Exercise 34:608–613CrossRefGoogle Scholar
  32. 32.
    Jurimae J, Jurimae T (2005) Leptin responses to short term exercise in college level male rowers. Br J Sports Med 39:6–9PubMedCrossRefGoogle Scholar
  33. 33.
    Leal-Cerro A, Garcia-Luna PP, Astorga R (1998) Serum leptin levels in male marathon athletes before and after the marathon run. J Clin Endocrinol Metab 83:2376–2379PubMedCrossRefGoogle Scholar
  34. 34.
    Olive JL, Miller GD (2001) Differential effects of maximal-and moderate-intensity run on plasma leptin in healthy trained subjects. Nutrition 17:365–369PubMedCrossRefGoogle Scholar
  35. 35.
    Reseland JE, Andessen SA, Solvoll K et al (2001) Effect of long-term change in diet and exercise on plasma leptin concentration. Clin Nutr 73:240–245Google Scholar
  36. 36.
    Fatouros IG, Tournis S, Leontsini D et al (2005) Leptin and adiponectin responses in overweight inactive elderly following resistance training and detraining are intensity related. J Clin Endocrinol Metab 90:5970–5977PubMedCrossRefGoogle Scholar
  37. 37.
    Kanaley JA, Fenicchia LM, Miller CS et al (2001) Resting leptin responses to acute and chronic resistance training in type 2 diabetic males and females. Int J Obes 25:1474–1480CrossRefGoogle Scholar
  38. 38.
    Essig DA, Alderson NL, Ferguson MA et al (2000) Delayed effects of exercise on the plasma leptin concentration. Metabolism 49:395–399PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia 2008

Authors and Affiliations

  • F. Rahmani-nia
    • 1
  • N. Rahnama
    • 2
    Email author
  • Z. Hojjati
    • 1
  • B. Soltani
    • 3
  1. 1.Department of Sports SciencesUniversity of GuilanRashtIran
  2. 2.Faculty of Physical Education and Sports SciencesUniversity of IsfahanIsfahanIran
  3. 3.Cellular and Molecular Research CenterGuilar University of Medical SciencesRashtIran

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