Psychiatrie und Psychotherapie

, Volume 3, Issue 2, pp 45–49 | Cite as

Alkoholbedingte Störungen – ein kleines Alphabet der Neurobiologie

  • Jakob Hein
  • Michael Rapp
  • Andreas Heinz


Die neurobiologische Forschung auf dem Gebiet alkoholbedingter Störungen hat in den letzten Jahren vielfältige wichtige Erkenntnisse erbracht, über die hier eine kurze Übersicht gegeben werden soll. Insbesondere haben sich neue Erkenntnisse auf dem Gebiet der genetischen Disposition dieser Störungen ergeben, aber auch bei der Erforschung der Neurotransmittersysteme konnten mit Hilfe tierexperimentieller Studien und Untersuchungsmethoden der Bildgebung neue Erkenntnisse gewonnen werden. Besonders Forschungsergebnisse zum hypothalamischen-hyophysiär Regelsystem, sowie Rezeptoren für Endocannabinoide und Opiate bieten neue, interessante Aspekte. Aus diesen neurobiologischen Erkenntnissen ergeben sich neue pharmakologische Behandlungsmöglichkeiten zur Behandlung alkoholbedingter Störungen.


Acamprosat ADH ALDH Alkoholabhängigkeit Cannabinoid-Rezeptoren Dopamin GABA Glutamat HHNNR-Regelachse Ketamin Naltrexon Opiat-Rezeptoren Serotonin 

Neurobiology's little alphabet of alcohol use disorders


Neurobiological research has yielded a variety of important results on the field of alcohol use disorders in recent years. This article tries to give a brief overview of these results. Especially in researching the genetic disposition many new results have come forward. But also on the field of neurotransmitter changes new findings using animal models as well as modern imaging methods were made. New and interesting insights come from research of the hypothalamic-pituitary gland hormonal systems, endocannabinoid receptors, as well as opiate receptors. New pharmacological approaches for the treatment of alcohol use disorders begin to evolve from these neurobiological findings.


Acamprosate ADH ALDH Alcohol dependence Cannabinoid-receptors Dopamine GABA Glutamate HPA-axis Ketamine Naltrexone Opiate-receptors Serotonin 


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Jakob Hein
  • Michael Rapp
  • Andreas Heinz
    • 1
  1. 1.Universitätsklinik für Psychiatrie und Psychotherapie, Charité – Universitätsmedizin BerlinBerlinGermany

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