Dose-response association between sleep duration and obesity risk: a systematic review and meta-analysis of prospective cohort studies

  • Qionggui Zhou
  • Zhang Ming Email author
  • Hu Dongsheng Email author
Sleep Breathing Physiology and Disorders • Review


The association between sleep duration and obesity risk remains unclear. We performed an updated meta-analysis to quantify a potential dose-response relation between sleep duration and risk of obesity. PubMed and Embase were searched for prospective cohort studies examining the association between sleep duration and risk of obesity that were published up to October 28, 2017. Random effects models were used to evaluate the pooled relative risks (RRs) and 95% confidence intervals (CIs) for the association of sleep duration and obesity. Restricted cubic splines were used to model the dose-response association. The meta-analysis included 12 studies (16 reports). We found a reverse J-shaped relation between sleep duration and obesity, with the lowest risk at 7–8-h sleep per day. Compared with 7-h sleep duration per day, the pooled relative risks for obesity were 1.09 (95% CI 1.05–1.14) for each 1-h decrement among individuals who slept < 7 h per day and 1.02 (95% CI 0.99–1.05) for each 1-h increment of sleep duration among individuals with longer sleep duration. Short sleep duration significantly increased the risk of obesity. Compared with 7-h sleep duration per day, the risk of obesity increases 9% for each 1-h decrease in sleep duration.


Sleep duration Obesity Cohort studies meta-analysis Dose-response relation 



This study was funded by the National Natural Science Foundation of China (grant nos. 81373074, 81402752, and 81673260); the Natural Science Foundation of Guangdong Province (grant no. 2017A030313452); the Science and Technology Development Foundation of Shenzhen (grant nos. JCYJ 20170302143855721 and JCYJ 20170412110537191); and the Postgraduate Innovation Development Fund Project of Shenzhen University (grant no. 31500004151).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

Not applicable for this meta-analysis in which all analyses were based on published literature.

Informed consent

Not applicable for this meta-analysis in which all analyses were based on published literature.

Supplementary material

11325_2019_1824_MOESM1_ESM.doc (1.2 mb)
ESM 1 (DOC 1274 kb)
11325_2019_1824_MOESM2_ESM.doc (27 kb)
ESM 2 Additional file: ESM 2 was received; however, no citation was provided in the manuscript. Please provide the location of where to insert the citation in the main body of the text. Otherwise, kindly advise us on how to proceed.Please note that additional files should be cited in ascending numerical order in the main body of the text.Dear editor, ESM 2 is a list of all authors who contributed to this study. We added all authors in the Appendix by following to the Editors comments when submitting the paper for the first time: "Authorship-23 named authors is too many for this paper as it is a review and meta-analysis. Please prepare a study group and place the additional named authors there. You could perhaps place your co-authors who conducted the data collection into a study group and the remaining should be named authors. Place place the names of the study group on the title page as XXX study group, then prepare an Appendix with the names of all members of the study group-including the named authors on the title page. This will ensure in case of acceptance that all named authors will be searchable in PubMed". If possible, please add this author list behind the first author (Qionggui Zhou) in order when this article is published. Please do not hesitate to contact me if you have any problems or questions (DOC 27 kb)


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Authors and Affiliations

  1. 1.Department of Preventive MedicineShenzhen University Health Science CenterShenzhenPeople’s Republic of China
  2. 2.Guangdong Key Laboratory for Genome Stability & Disease PreventionShenzhen University Health Science CenterShenzhenPeople’s Republic of China
  3. 3.The Affiliated Luohu Hospital of Shenzhen University Health Science CenterShenzhenPeople’s Republic of China

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