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Association of continuous positive airway pressure with F2-isoprostanes in adults with obstructive sleep apnea: a meta-analysis

  • Zhi-Wei Huang
  • Wu Ouyang
  • Liang-Ji Zhang
  • Hao Li
  • Yu-Ming Ye
  • Xue-Jun Lin
  • Qiao-Zhen Xu
  • Li Lin
  • Li-Da ChenEmail author
Sleep Breathing Physiology and Disorders • Original Article
  • 5 Downloads

Abstract

Purpose

Obstructive sleep apnea (OSA) is associated with increased F2-isoprostanes, a reliable standard biomarker of oxidative stress. Treatment with continuous positive airway pressure (CPAP) is effective for all degrees of OSA. However, it remains unknown whether treatment with CPAP will decrease F2-isoprostanes. A meta-analysis was conducted to determine the effect of CPAP treatment on F2-isoprostanes among patients with OSA.

Methods

The PubMed, Embase, Web of Science, and Cochrane library were searched before September, 2018. Eight articles assessing indices of F2-isoprostanes from various body fluids were identified. Pooled standardized mean difference (SMD) and weighted mean difference (WMD) were appropriately calculated through fixed or random effects models after assessing between-study heterogeneity.

Results

A total of 4 studies with 108 patients were pooled for exhaled breath condensate (EBC) F2-isoprostanes; 3 studies with 93 patients were pooled for serum or plasma F2-isoprostanes; and 3 studies with 102 patients were pooled for urinary F2-isoprostanes. A significant decrease of EBC F2-isoprostanes was observed after CPAP treatment (WMD = 2.652, 95% CI = 0.168 to 5.136, z = 2.09, p = 0.036), as well as serum or plasma F2-isoprostanes and urinary F2-isoprostanes (SMD = 1.072, 95% CI = 0.276 to 1.868, z = 2.64, p = 0.008 and WMD = 85.907, 95% CI = 50.443 to 121.372, z = 4.75, p = 0.000, respectively).

Conclusions

This meta-analysis suggested that CPAP therapy was associated with a significant decrease in F2-isoprostanes in patients with OSA.

Keywords

Obstructive sleep apnea Continuous positive airway pressure Oxidative stress F2-isoprostanes Meta-analysis 

Notes

Funding information

This work was supported by grant 2015-1-98 for Youth Research Fund from Fujian Provincial Health Bureau and grant 2017XQ1117 for Startup Fund for Scientific Research from Fujian Medical University. The funders had no role in study design, data collection, and analysis, decision to publish, or preparation of the manuscript.

Compliance with ethical standards

This article does not contain any studies with human participants performed by any of the authors.

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Zhi-Wei Huang
    • 1
  • Wu Ouyang
    • 2
  • Liang-Ji Zhang
    • 2
  • Hao Li
    • 2
  • Yu-Ming Ye
    • 2
  • Xue-Jun Lin
    • 3
  • Qiao-Zhen Xu
    • 2
  • Li Lin
    • 2
  • Li-Da Chen
    • 2
    • 4
    Email author
  1. 1.Department of OtolaryngologyQuanzhou First Hospital Affiliated to Fujian Medical UniversityQuanzhouPeople’s Republic of China
  2. 2.Department of Respiratory and Critical Care MedicineZhangzhou Affiliated Hospital of Fujian Medical UniversityZhangzhouPeople’s Republic of China
  3. 3.Department of Laboratory MedicineZhangzhou Affiliated Hospital of Fujian Medical UniversityZhangzhouPeople’s Republic of China
  4. 4.Department of Respiratory and Critical Care MedicineThe First Affiliated Hospital of Fujian Medical UniversityFuzhouPeople’s Republic of China

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