The effect of continuous positive airway pressure (CPAP) treatment on serum levels of proBDNF and mature BDNF in patients with obstructive sleep apnea

  • Yoshito MizoguchiEmail author
  • Jun-ichi Oyama
  • Yoshiomi Imamura
  • Koichi Node
  • Akira Monji
Sleep Breathing Physiology and Disorders • Letter to the Editors

To the Editor,

Obstructive sleep apnea (OSA) is caused by repetitive intermittent hypoxia and re-oxygenation during sleep and has been associated with an increased risk of many adverse health outcomes, including cognitive impairment, cardiovascular events, stroke, and depression. OSA is effectively treated by continuous positive airway pressure (CPAP) therapy [1], which protects pharyngeal airway to improve oxygenation during sleep. CPAP therapy can normalize sleep parameters of OSA and also ameliorate depressive symptoms. However, mechanisms underlying the effect of CPAP therapy on improvements of sleep parameters and/or depressive symptoms remain to be unclear.

Brain-derived neurotrophic factor (BDNF), one of neurotrophins, has various important roles in the brain. In addition to its neurotrophic actions, mature BDNF plays important roles in the regulation of glucose and lipid metabolism or the energy homeostasis in peripheral organs [2]. Accumulating evidence shows that serum BDNF...



This study was supported by grants from the Japan Agency for Medical Research and Development (AMED) (to Y.M and A.M) and the Japan Society for the Promotion of Science—KAKENHI ((C) to Y.M and A.M).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in this study were in accordance with the ethical standards of the Institutional Review Board of Human Research at Saga University and with the 1964 Helsinki declaration.

Informed consent

We obtained written informed consent from all individual participants in the study.


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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Yoshito Mizoguchi
    • 1
    Email author
  • Jun-ichi Oyama
    • 2
  • Yoshiomi Imamura
    • 1
  • Koichi Node
    • 2
  • Akira Monji
    • 1
  1. 1.Department of Psychiatry, Faculty of MedicineSaga UniversitySagaJapan
  2. 2.Department of Cardiovascular MedicineSaga UniversitySagaJapan

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