The effect of continuous positive airway pressure (CPAP) treatment on serum levels of proBDNF and mature BDNF in patients with obstructive sleep apnea
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To the Editor,
Obstructive sleep apnea (OSA) is caused by repetitive intermittent hypoxia and re-oxygenation during sleep and has been associated with an increased risk of many adverse health outcomes, including cognitive impairment, cardiovascular events, stroke, and depression. OSA is effectively treated by continuous positive airway pressure (CPAP) therapy , which protects pharyngeal airway to improve oxygenation during sleep. CPAP therapy can normalize sleep parameters of OSA and also ameliorate depressive symptoms. However, mechanisms underlying the effect of CPAP therapy on improvements of sleep parameters and/or depressive symptoms remain to be unclear.
Brain-derived neurotrophic factor (BDNF), one of neurotrophins, has various important roles in the brain. In addition to its neurotrophic actions, mature BDNF plays important roles in the regulation of glucose and lipid metabolism or the energy homeostasis in peripheral organs . Accumulating evidence shows that serum BDNF...
This study was supported by grants from the Japan Agency for Medical Research and Development (AMED) (to Y.M and A.M) and the Japan Society for the Promotion of Science—KAKENHI ((C) to Y.M and A.M).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
All procedures performed in this study were in accordance with the ethical standards of the Institutional Review Board of Human Research at Saga University and with the 1964 Helsinki declaration.
We obtained written informed consent from all individual participants in the study.
- 1.Ning Y, Zhang TS, Wen WW, Li K, Yang YX, Qin YW, Zhang HN, du YH, Li LY, Yang S, Yang YY, Zhu MM, Jiao XL, Zhang Y, Zhang M, Wei YX (2018) Effects of continuous positive airway pressure on cardiovascular biomarkers in patients with obstructive sleep apnea: a meta-analysis of randomized controlled trials. Sleep Breath. https://doi.org/10.1007/s11325-018-1662-2