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Weight gain may affect mandibular advancement device therapy in patients with obstructive sleep apnea: a retrospective study



The aim was to analyze whether or not weight gain influences the treatment outcome of patients with obstructive sleep apnea (OSA) treated with mandibular advancement devices (MAD).


As a part of a follow-up study among OSA patients treated with MAD in primary oral health care, a group of 28 patients reporting worsening of daytime or nighttime symptoms of OSA was given closer examination. Altogether, 21 subjects had a complete set of recordings and were enrolled into the study.


Only three subjects had lost weight during the study period. The mean weight gain of 3.6 kg ± 7.1 kg was significant (p = 0.035). According to linear regression, weight gain was independently significantly associated with lower mean peripheral oxygen saturation 92.4 (SD 1.8 (% per hour) (p = 0.019)) and lowest oxygen saturation 80.1 (SD 7.2 (%) (p = 0.024)) scores.


Weight gain is detrimentally associated with MAD treatment in patients with OSA. These findings suggest that regular follow-up by an experienced dentist is advisable to assess for possible worsening of OSA. Patient support to encourage weight control may be an important adjunct to MAD treatment for OSA.

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Correspondence to Tiina-Riitta Vuorjoki-Ranta.

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The authors declare that they have no conflict of interest.

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For this type of study, formal consent is not required.

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Informed consent was obtained from all individual participants included in the study.

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Vuorjoki-Ranta, T., Aarab, G., Lobbezoo, F. et al. Weight gain may affect mandibular advancement device therapy in patients with obstructive sleep apnea: a retrospective study. Sleep Breath 23, 531–534 (2019).

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  • Obstructive sleep apnea
  • Mandibular advancement device
  • Overweight
  • Primary health care