Sleep and Breathing

, Volume 23, Issue 1, pp 259–267 | Cite as

Bioinformatics analysis to reveal the key genes related to obstructive sleep apnea

  • Xiandong Gu
  • Wei Yang
  • Xuming Luo
  • Xiongbiao Wang
  • Jihong Tang
  • Zhuying CaiEmail author
Sleep Breathing Physiology and Disorders • Original Article



Obstructive sleep apnea (OSA) is induced by obstruction of the upper airway, which can raise multiple health risks. This study is designed to reveal the key genes involved in OSA.


GSE38792 was extracted from Gene Expression Omnibus database, including ten visceral adipose tissues from OSA patients and eight visceral adipose tissues from normal controls. Differential expression analysis was conducted using limma package, and then the functions of the differentially expressed genes (DEGs) were analyzed using DAVID database, followed by protein-protein interaction (PPI) network, and integrated regulatory network analysis was performed using Cytoscape software.


A total of 368 DEGs (176 upregulated and 192 downregulated) were identified in OSA samples. Epstein-Barr virus infection (involving IL10RB, MAPK9, and MAPK10) and olfactory transduction were the main pathways separately enriched for the upregulated genes and the downregulated genes. After the PPI network was built, the top ten network nodes (such as TXN) were selected according to node degrees. Two significant PPI network modules were identified. Moreover, the integrated regulatory network was constructed.


IL10RB, MAPK9, MAPK10, and TXN might function in the pathogenesis of OSA.


Obstructive sleep apnea Differentially expressed genes Enrichment analysis Protein-protein interaction network Integrated regulatory network 



This work was supported by Shanghai Municipal Commission of Health and Family Planning Science and Technology innovation project on traditional Chinese medicine (No.ZYKC201703008).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

This article does not contain any studies with human participants or animals performed by any of the authors.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Xiandong Gu
    • 1
  • Wei Yang
    • 1
  • Xuming Luo
    • 1
  • Xiongbiao Wang
    • 1
  • Jihong Tang
    • 1
  • Zhuying Cai
    • 1
    Email author
  1. 1.Department of Respiratory Medicine, Putuo HospitalShanghai University of Traditional Chinese MedicineShanghaiChina

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