Benefit of continuous positive airway pressure on work quality in patients with severe obstructive sleep apnea

  • Elsa BotokekyEmail author
  • N. Freymond
  • F. Gormand
  • P. Le Cam
  • G. Chatte
  • J. Kuntz
  • M. N. Liegeon
  • M. Gaillot-Drevon
  • A. Massardier-Pilonchery
  • A. Fiquemont
  • E. Fort
  • M. Marcu
  • T. Petitjean
  • B. Charbotel
Sleep Breathing Physiology and Disorders • Original Article



The objective of this prospective study was to assess the effect of CPAP therapy on job productivity and work quality for patients with severe obstructive sleep apnea (OSA).


A convenience sample of patients diagnosed with severe OSA using polysomnography or polygraphy and with a therapeutic indication for CPAP was enrolled in our study. Patients completed two self-administered questionnaires: the first before CPAP therapy and the second during the first 6 months after CPAP treatment. OSA symptoms were evaluated through self-administered questionnaires assessing potential effects on occupational activity: excessive daytime sleepiness was rated by the Epworth Sleepiness Scale (ESS), emotional status was rated by the Hospital Anxiety and Depression (HAD) scale, work quality was rated by the Work Role Functioning Questionnaire (WRFQ).


Forty patients (30 men, mean age 47.3 ± 8.3, mean BMI 31.6 ± 7.4, mean apnea-hypopnea index 51.8 ± 16.3) showed a beneficial effect of CPAP therapy on ESS score (mean 11.6 to 8.2, p < 0.0001), the anxiety dimension (mean 57.5% to 20%, p = 0.0002), and the overall anxiety-depressive score (mean 50% to 22.5%, p = 0.0006). Mean WRFQ scores were significantly improved in the second questionnaire for the dimensions of timetable requirements (69.3% to 83.5%, p < 0.0001), productivity requirements (71.4% to 82.2%, p < 0.0001), mental requirements (72.0% to 84.3%, p < 0.0001), and social requirements (82.6% to 91.4%, p < 0.003).


We observed that adherence to CPAP therapy for patients with severe OSA mitigates the impact of symptoms on work including excessive daytime sleepiness, impairment of work ability, and anxiety and depressive disorders.


Obstructive sleep apnea CPAP Job productivity Work limitation 



Apnea-hypopnea index

AUDIT-C questionnaire C

Alcohol Use Disorders Identification Test Consumption


Body mass index


Comité consultatif sur le traitement de l’information en matière de recherche en santé


Comité consultatif sur le traitement de l’information en matière de recherche en santé


Continuous positive airway pressure


Comité de protection des personnes


Epworth Sleepiness Scale


Hospital Anxiety and Depression


Haute autorité de santé


Obstructive sleep apnea


The first quartile


The third quartile


Work Limitation Questionnaire


Work Role Functioning Questionnaire


Compliance with ethical standards

Ethical responsibilities of authors

All persons gave their informed consent prior to their inclusion in the study. Details that might disclose the identity of the subjects under study are omitted. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Elsa Botokeky
    • 1
    • 2
    Email author
  • N. Freymond
    • 3
  • F. Gormand
    • 4
  • P. Le Cam
    • 4
  • G. Chatte
    • 5
  • J. Kuntz
    • 5
  • M. N. Liegeon
    • 5
  • M. Gaillot-Drevon
    • 3
  • A. Massardier-Pilonchery
    • 1
    • 2
  • A. Fiquemont
    • 6
  • E. Fort
    • 2
  • M. Marcu
    • 3
  • T. Petitjean
    • 4
  • B. Charbotel
    • 1
    • 2
  1. 1.Department of Occupational DiseasesCHU LyonPierre-BéniteFrance
  2. 2.Université de Lyon, Université Claude Bernard Lyon 1, IFSTTAR, UMRESTTELyonFrance
  3. 3.Department of Respiratory MedicineCentre Hospitalier Lyon Sud, CHU LyonPierre-BéniteFrance
  4. 4.Department of Sleep DisordersCentre Hospitalier Croix Rousse, CHU LyonLyonFrance
  5. 5.Private Practice PneumologyCaluire-et-CuireFrance
  6. 6.University Claude Bernard Lyon 1LyonFrance

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