Treatment-emergent central sleep apnea (TE-CSA) is defined as the emergence or persistence of central respiratory events during the initiation of positive airway pressure (PAP) without a back-up rate in obstructive sleep apnea (OSA) patients and after significant resolution of obstructive events. Previous studies have estimated a prevalence from 0.56 to 20.3%. The aim of this study was to establish the prevalence of TE-CSA in a Greek adult population.
One thousand fifty nine patients with newly diagnosed OSA, who were referred to the Sleep Disorders Center of Evangelismos Hospital of Athens over an 18-month period, were included in this study. A split-night polysomnography (PSG), or two formal overnight PSGs (diagnostic and continuous PAP (CPAP) titration study), were performed.
Patients with OSA were divided in two groups; the first group included 277 patients, who underwent two separate studies (diagnostic and CPAP titration study), and the second group 782 patients, who underwent split-night studies. The prevalence of TE-CSA in the first group was 2.53% (7 patients), and in the second group was 5.63% (44 patients).
The prevalence of TE-CSA in Greece was lower compared to most previous reported studies. The significant variation in the prevalence of TE-CSA between different centers throughout the world is mainly associated with the used diagnostic criteria as well as methodological and technical aspects.
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This study has been approved by our Institutional Research Ethics Committee and it also complies to the Declaration of Helsinski.
Conflict of interest
All authors declare that they have no conflict of interest.
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Baou, K., Mermigkis, C., Minaritzoglou, A. et al. Complex sleep apnea after full-night and split-night polysomnography: the Greek experience. Sleep Breath 22, 713–719 (2018). https://doi.org/10.1007/s11325-017-1601-7
- Complex sleep apnea
- Central apneas
- Obstructive sleep apnea
- CPAP apparatus