Sleep and Breathing

, Volume 21, Issue 3, pp 697–701 | Cite as

Hydroxyurea treatment effect on children with sickle cell disease and obstructive sleep apnea

  • Anthony J. Grady
  • Jane S. Hankins
  • Brent Haberman
  • Robert Schoumacher
  • Rose Mary Stocks
Sleep Breathing Physiology and Disorders • Short Communication

Abstract

Background

While hydroxyurea is the mainstay of treatment for many of the comorbidities associated with sickle cell disease, its effect on obstructive sleep apnea has not been fully investigated. The purpose of this project is to help characterize the effects of hydroxyurea on obstructive sleep apnea in children with sickle cell disease and determine its therapeutic role in the condition.

Methods

Chart review was conducted on two pediatric patients with sickle cell disease who experienced resolution of obstructive sleep apnea following hydroxyurea administration.

Results

After undergoing approximately 11 months of hydroxyurea therapy, sleep apnea symptoms improved and obstructive sleep apnea resolution was confirmed by repeat polysomnography in both cases. This resolution was largely secondary to a reduction in the obstructive component of the apnea hypopnea index, highlighting a previously unreported association.

Conclusions

As adenotonsillectomy is associated with significant risks in patients with sickle cell disease, it appears reasonable to consider a period of observation for improvement of obstructive sleep apnea following hydroxyurea administration rather than directly proceeding with surgery.

Keywords

Obstructive sleep apnea Sickle cell disease Hydroxyurea Pediatric Adenotonsillectomy Polysomnography 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  • Anthony J. Grady
    • 1
  • Jane S. Hankins
    • 2
  • Brent Haberman
    • 3
  • Robert Schoumacher
    • 3
  • Rose Mary Stocks
    • 1
  1. 1.Department of Otolaryngology, Head and Neck SurgeryUniversity of Tennessee Health Science CenterMemphisUSA
  2. 2.Department of HematologySt. Jude Children’s Research HospitalMemphisUSA
  3. 3.Department of Pediatric PulmonologyUniversity of Tennessee Health Science CenterMemphisUSA

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