Sleep and Breathing

, Volume 21, Issue 1, pp 149–154 | Cite as

Sleep disorders in patients with multiple sclerosis in China

  • Shengli MaEmail author
  • Xue Rui
  • Peiyi Qi
  • Gangqiong Liu
  • Jing Yang
Neurology • Original Article



Poor sleep is common in patients with multiple sclerosis (MS). This study assessed the prevalence of poor sleep and investigated the potential impact factors that influence sleep quality of patients with MS.


A cross-sectional self-report survey of 231 patients with MS and 265 sex- and age-matched controls was conducted. Good sleepers and poor sleepers were separated by their global score on the Pittsburgh Sleep Quality Index (PSQI). Sociodemographic parameters, such as age, gender, and marital status, and clinical-demographic parameters, such as excessive daytime sleepiness (measured by the Epworth Sleepiness Scale), snoring, insomnia, obstructive sleep apnea, drugs, pain, depression, fatigue, and quality of life, were registered. Clinical and sociodemographic parameters were compared between patients with MS and controls and between good and poor sleepers among patients with MS.


The prevalence of poor sleep in patients with MS was 64.9. Univariate analysis found that gender (p < 0.001), antidepressant drugs (p < 0.001), insomnia (p < 0.001), fatigue (p < 0.001), Epworth Sleepiness Scale (ESS) (p < 0.001), pain (p < 0.001), and depression (p < 0.001) were associated with sleep disorders. Multivariate analysis revealed that female gender, antidepressant drug treatment, and a high psychological burden of MS may be risk factors for poor sleep among patients with MS.


Poor sleep is more common in patients with MS than in the general population. Sleep disorders should routinely be evaluated in patients with MS to improve the quality of sleep among them.


Multiple sclerosis Sleep disorder Poor sleep China 



We thank all the participants and staff who took part in the questionnaire survey.

Compliance with ethical standards


No funding was received for this research.

Conflict of interest

The authors declare that they have no competing interests.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Additional informed consent was obtained from all individual participants for whom identifying information is included in this article.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Shengli Ma
    • 1
    Email author
  • Xue Rui
    • 2
  • Peiyi Qi
    • 1
  • Gangqiong Liu
    • 3
  • Jing Yang
    • 4
  1. 1.Department of Emergency, Institute of Clinic MedicineThe First Affiliated Hospital of Zhengzhou UniversityZhengzhouPeople’s Republic of China
  2. 2.Institute of Clinical MedicineThe First Affiliated Hospital of Zhengzhou UniversityZhengzhouPeople’s Republic of China
  3. 3.Department of CardiologyThe First Affiliated Hospital of Zhengzhou UniversityZhengzhouPeople’s Republic of China
  4. 4.Department of neurologyThe First Affiliated Hospital of Zhengzhou UniversityZhengzhouPeople’s Republic of China

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