Advertisement

Sleep and Breathing

, Volume 20, Issue 1, pp 271–276 | Cite as

Sleep bruxism frequency and platelet serotonin transporter activities in young adult subjects

  • Hajime MinakuchiEmail author
  • Chiharu Sogawa
  • Haruna Miki
  • Emilio S. Hara
  • Kenji Maekawa
  • Norio Sogawa
  • Shigeo Kitayama
  • Yoshizo Matsuka
  • Glenn Thomas Clark
  • Takuo Kuboki
Neurology • Original Article

Abstract

Purpose

To evaluate correlations between serotonin transporter (SERT) uptake ability in human peripheral platelets and sleep bruxism (SB) frequency.

Methods

Subjects were consecutively recruited from sixth-year students at Okayama University Dental School. Subjects were excluded if they (1) were receiving orthodontic treatment, (2) had a dermatological disease, (3) had taken an antidepressant within 6 months, or (4) had used an oral appliance within 6 months. SB frequency was determined as the summary score of three consecutive night assessments using a self-contained electromyography detector/analyzer in their home. Fasting peripheral venous blood samples were collected in the morning following the final SB assessment. SERT amount and platelet number were quantified via an ELISA assay and flow cytometry, respectively. Functional SERT characterization, 5-hydroxytryptamine (5-HT) uptake, maximum velocity (V max), and an affinity constant (K m ) were assessed with a [3H] 5-HT uptake assay. The correlations between these variables and SB level were evaluated.

Results

Among 50 eligible subjects (26 males, mean age 25.4 ± 2.41 years), 7 were excluded because of venipuncture failure, smoking, and alcohol intake during the experimental period. A small but significant negative correlation between SB level and [3H] 5-HT uptake was observed (Spearman’s correlation R 2 = 0.063, p = 0.04). However, there were no significant correlations between SB level and total platelet amount, SERT, V max, and K m values (p = 0.08, 0.12, 0.71, and 0.68, respectively).

Conclusions

Platelet serotonin uptake is significantly associated with SB frequency, yet only explains a small amount of SB variability.

Keywords

Sleep bruxism Human serotonin transporter Uptake ability Electromyography (EMG) Peripheral platelet 

Notes

Funding

The Ministry of Education, Science and Culture, Japan, provided financial support in the form of Grant-in-Aid ((B) No. 23390442) and Grant-in-Aid for Exploratory Research (No. 25670819) . The sponsor had no role in the design or conduct of this research.

Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements) or non-financial interest (such as personal or professional relationships, affiliations, knowledge, or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

References

  1. 1.
    Lobbezoo F, Ahlberg J, Glaros AG, Kato T, Koyano K, Lavigne GJ, de Leeuw R, Manfredini D, Svensson P, Winocur E (2013) Bruxism defined and graded: an international consensus. J Oral Rehabil 40:2–4. doi: 10.1111/joor.12011 CrossRefPubMedGoogle Scholar
  2. 2.
    Beier US, Kapferer I, Dumfahrt H (2012) Clinical long-term evaluation and failure characteristics of 1,335 all-ceramic restorations. Int J Prosthodont 25:70–78PubMedGoogle Scholar
  3. 3.
    JohanssonA OR, Carlsson GE (2011) Bruxism and prosthetic treatment: a critical review. J Prosthodont Res 55:127–136. doi: 10.1016/j.jpor.2011.02.004 CrossRefGoogle Scholar
  4. 4.
    Pistorius A, Krahwinkel T, Willershausen B, Boekstegen C (2002) Relationship between stress factors and periodontal disease. Eur J Med Res 7:393–398PubMedGoogle Scholar
  5. 5.
    Ono Y, Suganuma T, Shinya A, Furuya R, Baba K (2008) Effects of sleep bruxism on periodontal sensation and tooth displacement in the molar region. Cranio 26:282–286PubMedGoogle Scholar
  6. 6.
    Rompre PH, Daigle-Landry D, Guitard F, Montplaisir JY, Lavigne GJ (2007) Identification of a sleep bruxism subgroup with a higher risk of pain. J Dent Res 86:837–842CrossRefPubMedGoogle Scholar
  7. 7.
    Nagamatsu-Sakaguchi C, Minakuchi H, Clark GT, Kuboki T (2008) Relationship between the frequency of sleep bruxism and the prevalence of signs and symptoms of temporomandibular disorders in an adolescent population. Int J Prosthodont 21:292–298PubMedGoogle Scholar
  8. 8.
    Baba K, Haketa T, Sasaki Y, Ohyama T, Clark GT (2005) Association between masseter muscle activity levels recorded during sleep and signs and symptoms of temporomandibular disorders in healthy young adults. J Orofac Pain 19:226–31PubMedGoogle Scholar
  9. 9.
    Ak M, Gulsun M, Uzun O, Gumus HO (2009) Bruxism associated with serotonin reuptake inhibitors: two cases. J Clin Psychopharmacol 29:620–622. doi: 10.1097/JCP.0b013e3181c0e942 CrossRefPubMedGoogle Scholar
  10. 10.
    Romanelli F, Adler DA, Bungay KM (1996) Possible paroxetine-induced bruxism. Ann Pharmacother 30:1246–1248PubMedGoogle Scholar
  11. 11.
    Sabuncuoglu O, Ekinci O, Berkem M (2009) Fluoxetine-induced sleep bruxism in an adolescent treated with buspirone: a case report. Spec Care Dentist 29:215–217. doi: 10.1111/j.1754-4505.2009.00091 CrossRefPubMedGoogle Scholar
  12. 12.
    Kishi Y (2007) Paroxetine-induced bruxism effectively treated with tandospirone. J Neuropsychiatry Clin Neurosci 19:90–91CrossRefPubMedGoogle Scholar
  13. 13.
    Cui L, Wang JH, Wang M, Huang M, Wang CY, Xia H, Xu JG, Li MX, Wang S (2012) Injection of L-glutamate into the insular cortex produces sleep apnea and serotonin reduction in rats. Sleep Breath 16:845–853. doi: 10.1007/s11325-011-0586-x CrossRefPubMedGoogle Scholar
  14. 14.
    McCall RB, Aghajanian GK (1979) Serotonergic facilitation of facial motoneuron excitation. Brain Res 169:11–27CrossRefPubMedGoogle Scholar
  15. 15.
    Inoue T, Itoh S, Kobayashi M, Kang Y, Matsuo R, Wakisaka S, Morimoto T (1999) Serotonergic modulation of the hyperpolarizing spike afterpotential in rat jaw-closing motoneurons by PKA and PKC. J Neurophysiol 82:626–637PubMedGoogle Scholar
  16. 16.
    Camacho A, Dimsdale JE (2000) Platelets and psychiatry: lessons learned from old and new studies. Psychosom Med 62:326–336CrossRefPubMedGoogle Scholar
  17. 17.
    Lesch KP, Wolozin BL, Murphy DL, Reiderer P (1993) Primary structure of the human platelet serotonin uptake site: identity with the brain serotonin transporter. J Neurochem 60:2319–2322CrossRefPubMedGoogle Scholar
  18. 18.
    Minakuchi H, Sogawa C, Hara ES, Miki H, Maekawa K, Sogawa N et al (2014) Comparison of platelet serotonin transporter activity in subjects with severe sleep bruxism and control. J Prosthodont Res 58:217–222. doi: 10.1016/j.jpor.2014.06.003 CrossRefPubMedGoogle Scholar
  19. 19.
    Shochat T, Gavish A, Arons E, Hadas N, Molotsky A, Lavie P, Oksenberg A (2007) Validation of the BiteStrip screener for sleep bruxism. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104:32–39CrossRefGoogle Scholar
  20. 20.
    Mainieri VC, Saueressig AC, Pattussi MP, Fagondes SC, Grossi ML (2012) Validation of the Bitestrip versus polysomnography in the diagnosis of patients with a clinical history of sleep bruxism. Oral Surg Oral Med Oral Pathol Oral Radiol 113:612–617. doi: 10.1016/j.oooo.2011.10.008 CrossRefPubMedGoogle Scholar
  21. 21.
    Makino M, Masaki C, Tomoeda K, Kharouf E, Nakamoto T, Hosokawa R (2009) The relationship between sleep bruxism behavior and salivary stress biomarker level. Int J Prosthodont 22:43–48PubMedGoogle Scholar
  22. 22.
    Minakuchi H, Sakaguchi C, Hara ES, Maekawa K, Matsuka Y, Clark GT, Kuboki T (2012) Multiple sleep bruxism data collected using a self-contained EMG detector/analyzer system in asymptomatic healthy subjects. Sleep Breath 16:1069–1072. doi: 10.1007/s11325-011-0602-1 CrossRefPubMedGoogle Scholar
  23. 23.
    Sogawa C, Sogawa N, Ohyama K, Kikura-Hanajiri R, Goda Y, Sora I, Kitayama S (2011) Methylone and monoamine transporters: correlation with toxicity. Curr Neuropharmacol 9:58–62. doi: 10.2174/157015911795017425 CrossRefPubMedPubMedCentralGoogle Scholar
  24. 24.
    Kand EH, Shim HB, Kim KJ, Park JE, Lee IS, Yu BH (2010) Platelet serotonin transporter function after short-term paroxetine treatment in patients with panic disorder. Psychiat Res 176:250–253. doi: 10.1016/j.psychres.2008.12.007 CrossRefGoogle Scholar
  25. 25.
    Fernandes G, Franco AL, Siqueira JT, Gonçalves DA, Camparis CM (2012) Sleep bruxism increases the risk for painful temporomandibular disorder, depression and non-specific physical symptoms. J Oral Rehabil 39:538–544. doi: 10.1111/j.1365-2842.2012.02308 CrossRefPubMedGoogle Scholar
  26. 26.
    Manfredini D, Landi N, Fantoni F, Segù M, Bosco M (2005) Anxiety symptoms in clinically diagnosed bruxers. J Oral Rehabil 32:584–588CrossRefPubMedGoogle Scholar
  27. 27.
    Pingitore G, Chrobak V, Petrie J (1991) The social and psychologic factors of bruxism. J Prosthet Dent 65:443–446CrossRefPubMedGoogle Scholar
  28. 28.
    Abe Y, Suganuma T, Ishii M, Yamamoto G, Gunji T, Clark GT, Tachikawa T, Kiuchi Y, Igarashi Y, Baba K (2012) Association of genetic, psychological and behavioral factors with sleep bruxism in a Japanese population. J Sleep Res 21:289–296. doi: 10.1111/j.1365-2869.2011.00961 CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Hajime Minakuchi
    • 1
    • 2
    Email author
  • Chiharu Sogawa
    • 2
  • Haruna Miki
    • 2
  • Emilio S. Hara
    • 2
  • Kenji Maekawa
    • 2
  • Norio Sogawa
    • 3
  • Shigeo Kitayama
    • 2
  • Yoshizo Matsuka
    • 4
  • Glenn Thomas Clark
    • 5
  • Takuo Kuboki
    • 1
  1. 1.Department of Oral Rehabilitation and Regenerative MedicineOkayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesOkayamaJapan
  2. 2.Department of Dental PharmacologyOkayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesOkayamaJapan
  3. 3.Department of Dental PharmacologyMatsumoto Dental UniversityNaganoJapan
  4. 4.Department of Stomatgnathic Function and Occlusal Reconstruction, Institute of Biomedical Science, Clinical DentistryTokushima University Graduate SchoolTokushima CityJapan
  5. 5.Advanced Program in Orofacial Pain and Oral Medicine, Ostrow School of DentistryUniversity of Southern CaliforniaLos AngelesUSA

Personalised recommendations