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Sleep and Breathing

, Volume 20, Issue 2, pp 569–574 | Cite as

Shorter sleep duration is associated with poorer glycemic control in type 2 diabetes patients with untreated sleep-disordered breathing

  • Nantaporn Siwasaranond
  • Hataikarn Nimitphong
  • Sunee Saetung
  • Naricha Chirakalwasan
  • Boonsong Ongphiphadhanakul
  • Sirimon Reutrakul
Sleep Breathing Physiology and Disorders • Original Article

Abstract

Purpose

The purpose of this study is to explore the impact of sleep duration on glycemic control in type 2 diabetes patients with untreated sleep-disordered breathing (SDB).

Methods

Ninety type 2 diabetes patients participated in the study. SDB was diagnosed using an overnight in-home monitoring device (WatchPAT200). Sleep duration was recorded by wrist actigraphy for 7 days. Medical records were reviewed for hemoglobin A1c (HbA1c) values.

Results

Seventy-one patients (78.8 %) were diagnosed with SDB [apnea-hypopnea index (AHI) ≥ 5]. In patients with SDB, there was no significant relationship between AHI and glycemic control. In addition, oxygen desaturation index, minimum oxygen saturation, and time spent below oxygen saturation of 90 % were not significantly correlated with glycemic control. Sleep duration, however, was inversely correlated with HbA1c (r = −0.264, p 0.026). Multiple regression analysis adjusting for age, sex, body mass index, insulin use, diabetes duration, and AHI revealed that sleep duration was significantly associated with HbA1c (p = 0.005). Each hour reduction in sleep duration was associated with a 4.8 % increase in HbA1c of its original value (95 % CI 1.5–8.0).

Conclusion

In type 2 diabetes patients with untreated SDB, shorter sleep duration was independently associated with poorer glycemic control. Sleep duration optimization may lead to improved glycemic control in this population.

Keywords

Sleep-disordered breathing Obstructive sleep apnea Sleep duration Diabetes Glycemic control Short sleep duration 

Notes

Acknowledgments

The study received grant support from Mahidol University.

Conflict of interest

S.R. received speaker honoraria from Sanofi Aventis and research grant from Merck. All other authors disclosed no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Nantaporn Siwasaranond
    • 1
  • Hataikarn Nimitphong
    • 1
  • Sunee Saetung
    • 1
  • Naricha Chirakalwasan
    • 2
    • 3
  • Boonsong Ongphiphadhanakul
    • 1
  • Sirimon Reutrakul
    • 1
  1. 1.Section of Endocrinology, Department of Medicine, Faculty of Medicine Ramathibodi HospitalMahidol UniversityBangkokThailand
  2. 2.Division of Pulmonary and Critical Care Medicine, Department of Medicine, Faculty of MedicineChulalongkorn UniversityBangkokThailand
  3. 3.Excellence Center for Sleep Disorders, King Chulalongkorn Memorial HospitalThai Red Cross SocietyBangkokThailand

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