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Sleep and Breathing

, Volume 18, Issue 2, pp 243–249 | Cite as

Autophagy and hippocampal neuronal injury

  • Lulu Li
  • Qiang Zhang
  • Jin Tan
  • Yunyun Fang
  • Xu An
  • Baoyuan Chen
Review

Abstract

Background

Autophagy is a specific universal biological phenomenon in eukaryotic cells, which is characterized by cytoplasmic vacuoles in the process of degrading cellular contents in lysosomes. The hippocampus plays an important role in higher nervous activities such as emotional integration, cognition, and memory. As an area closely related to learning and memory functions of the brain, the hippocampus is particularly sensitive to injuries caused by various reasons.

Purpose

Autophagy has certain links with a variety of causes of hippocampal neuronal injury. This short review discusses and summarizes this correlation with a focus on the possible role of autophagy and mechanisms in it.

Conclusion

The current correlation between autophagy and hippocampal neuronal injury has not been completely determined by the general public alike. Further studies are needed to determine special effects of autophagy on hippocampal neuronal injury, which might accelerate the development of therapeutic interventions in hippocampal neuronal injury in many neurological disorders.

Keywords

Autophagy Hippocampal neurons Alzheimer’s disease (AD) Hypoxia–ischemia Excitotoxicity Vitamin E 

Notes

Acknowledgments

This work was supported by a grant from the National Natural Science Foundation of China (no. 81370183) and a grant from Natural Science Foundation of Tianjin (no. 13JCYBJC23700).

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Lulu Li
    • 1
  • Qiang Zhang
    • 1
  • Jin Tan
    • 1
  • Yunyun Fang
    • 1
  • Xu An
    • 1
  • Baoyuan Chen
    • 2
  1. 1.Tianjin Institute of GeriatricsTianjin Medical University General HospitalTianjinChina
  2. 2.Department of RespirationTianjin Medical University General HospitalTianjinChina

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