Increased sleep latency and reduced sleep duration in children with asthma
- 323 Downloads
Sleep disturbance is reported to be more prevalent in children and adolescents with asthma than those without. However, this has not been described adequately using objective measures. The aim of this study was to objectively characterise sleep disturbance in asthmatic and non-asthmatic children and adolescents.
A retrospective analysis of polysomnography recordings from children aged 5–17 years old, with (n = 113) and without asthma (n = 104), referred for a sleep study over the period 2005–2010 at the Paediatric Sleep Unit, John Hunter Children’s Hospital in Newcastle, NSW Australia, was carried out.
Polysomnographic recordings were analysed to compare sleep quality and quantity between asthmatic and non-asthmatic children. Sleep latency was significantly longer in asthmatic children compared to controls. However, this result was significant for females only (46.2 (5.6) vs 33.2 (2.7) min, p < 0.05). Male asthmatics had significantly shorter sleep duration (425.9 (5.4) vs 441.8 (5.4) min, p < 0.05) than male controls.
Sleep disturbance exists in children with asthma and manifests differently in males and females. Further investigation into the clinical implication of increased sleep latency and reduced sleep duration upon daytime functioning and lifestyle behaviours in children and adolescents with asthma is warranted.
KeywordsAdolescent Asthma Child Polysomnography Sleep
Body mass index
Forced expiratory volume in one second
Forced vital capacity
Pulmonary expiratory flow
Paediatric sleep unit
Respiratory disturbance index
Rapid eye movement
Standard error mean
Total sleep time
Total time awake
Obstructive sleep apnea
The authors acknowledge the work of the John Hunter Children’s Hospital Paediatric Sleep Unit staff for the collection, extraction, and scoring of the polysomnography data.
Conflict of interest
The authors declare that they have no conflict of interest.
- 1.Masoli M, Fabian D, Holt S, Beasley R (2004) Global burden of asthma: a report prepared for the global initiative for asthma. GINA: 1-12Google Scholar
- 2.Australian Centre for Asthma Monitoring (2009) Asthma in Australian children: findings from Growing Up in Australia, the longitudinal study of Australian children. Australian Institute of Health and Welfare, CanberraGoogle Scholar
- 3.Australian Centre for Asthma Monitoring (2008) Asthma in Australia. In: AIHW asthma series no. 3. Australian Institute of Health and Welfare, Canberra.Google Scholar
- 7.Luyster F, Teodorescu M, Bleecker E, Busse W, Calhoun W, Castro M, Chung K, Erzurum S, Israel E, Strollo P, Wenzel S (2011) Sleep quality and asthma control and quality of life in non-severe and severe asthma. Sleep Breath. doi: 10.1007/s11325-011-0616-8
- 11.Spruyt K, Molfese DL, Gozal D (2011) Sleep duration, sleep regularity, body weight, and metabolic homeostasis in school-aged children. Pediatrics. doi: 10.1542/peds.2010-0497
- 14.Gangwisch JE, Malaspina D, Babiss LA, Opler MG, Posner K, Shen S, Turner JB, Zammit GK, Ginsberg HN, Gangwisch JE, Malaspina D, Babiss LA, Opler MG, Posner K, Shen S, Turner JB, Zammit GK, Ginsberg HN (2010) Short sleep duration as a risk factor for hypercholesterolemia: analyses of the National Longitudinal Study of Adolescent Health. Sleep 33(7):956–961PubMedGoogle Scholar
- 21.Rechtschaffen A, and Kales A. (1968) A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects. US Dept. of Health, Education, and Welfare, Public Health Services—National Institutes of Health, National Institute of Neurological Diseases and Blindness, Neurological Information Network, Los Angeles.Google Scholar
- 22.Loughlin G, Broullette R et al (1996) American Thoracic Society: standards and indications for cardiopulmonary sleep studies in children. Am J Respir Crit Care Med 153:866–878Google Scholar
- 23.Thoracic Society of Australia and New Zealand (1994) Guidelines for respiratory sleep studies. TSANZ, AustraliaGoogle Scholar
- 31.Forbes EE, Bertocci MA, Gregory AM, Ryan ND, Axelson DA, Birmaher B, Dahl RE, Forbes EE, Bertocci MA, Gregory AM, Ryan ND, Axelson DA, Birmaher B, Dahl RE (2008) Objective sleep in pediatric anxiety disorders and major depressive disorder. J Am Acad Child Adolesc Psychiatr 47(2):148–155CrossRefGoogle Scholar