Head-and-neck paragangliomas are associated with sleep-related complaints, especially in the presence of carotid body tumors
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Abstract
Objectives
The carotid body functions as a chemoreceptor. We hypothesized that head-and-neck paragangliomas (HNP) may disturb the function of these peripheral chemoreceptors and play a role in sleep-disordered breathing.
Design
This is a case–control study.
Setting
This study was conducted in a tertiary referral center.
Participants and main outcome measures
We assessed fatigue, sleep, and exercise capacity in 74 HNP patients using three questionnaires (Epworth Sleepiness Scale, St. George Respiratory Questionnaire, and a standard clinical sleep assessment questionnaire). Outcomes were compared to those of age- and sex-matched controls.
Results and conclusions
Activity, disturbance of psychosocial function, and total score were worse compared to controls (15.4 ± 18.5 vs. 7.2 ± 9.9, P = 0.007; 5.3 ± 10.5 vs. 1.2 ± 2.6, P = 0.008; and 10.4 ± 12.9 vs. 5.0 ± 4.8, P = 0.006, respectively). Patients reported more daytime fatigue, concentration difficulties, and depression (51% vs. 24%, P = 0.006; 31% vs. 10%, P = 0.010; and 19% vs. 2%, P = 0.012). Waking up was reported to be less refreshing in HNP patients (53% vs. 73%, P = 0.038). Dysphonia was a predictor of symptoms, activity, disturbance of psychosocial function, and total scores. Remarkably, the presence of a carotid body tumor was an independent predictor of increased daytime sleepiness (β = 0.287, P = 0.029). In conclusion, patients with HNP have remarkable sleep-related complaints. Especially the presence of carotid body tumors appears to be associated with increased daytime somnolence.
Keywords
Paraganglioma Glomus tumors Carotid body tumor Sleep SDHD mutationAbbreviations
- HNP
Head-and-neck paraganglioma
- CBT
Carotid body tumor
- ESS
Epworth Sleepiness Scale
- SGRQ
St. George Respiratory Questionnaire
- SCAQ
Standard clinical assessment questionnaire
Introduction
Head-and-neck paragangliomas (HNP) are highly vascularised tumors originating from neural crest-derived chief cells of the paraganglia belonging to the autonomic nervous system and are also known as glomus tumors. One of the paraganglia in the neck is the carotid body which normally functions as a peripheral chemoreceptor by registering the arterial oxygen and carbon dioxide (CO2) concentration [1, 2, 3, 4, 5, 6, 7]. HNP are most frequently found in the carotid body region and this subset of paragangliomas is called carotid body tumors (CBT). Paragangliomas can occur in a hereditary context. Familial paraganglioma syndromes are associated with germline mutations in the genes encoding the B, C, and D subunits of mitochondrial complex II succinate dehydrogenase (SDH). These SDH genes may behave as tumor suppressor genes [8, 9, 10]. Among these three genes, mutations in SDH-D subunit are the most prominent cause of HNP [11, 12, 13, 14].
Although these tumors are usually benign, the location of HNP in close proximity to nerves and vasculature can result in considerable morbidity. Patients often complain of progressive dysphagia, dysphonia, and hearing loss. We recently found that quality of life (QoL) parameters, assessed by validated questionnaires, are reduced in paraganglioma patients [15]. These patients frequently reported fatigue, reduced exercise tolerance, and impaired sleep. This disturbed sleep is of interest since the metabolic ventilatory control system is fine-tuned by two sets of chemoreceptors, the peripheral chemoreceptors in the carotid bodies and the central CO2 chemoreceptors in the ventral medulla. Bilateral dysfunction of carotid body chemoreceptors causes an abolition of the ventilatory response to hypoxia under normocapnic conditions [16, 17]. The permanent absence of the breathing response to hypoxia and the reduction of central CO2 sensitivity after bilateral carotid body resection may worsen sleep-disordered breathing [18]. Therefore, the aim of the present study was to specify sleep-related complaints in paraganglioma patients, especially in those with carotid body tumors, using three questionnaires: Epworth Sleepiness Scale (ESS), St. George Respiratory Questionnaire (SGRQ), and a third questionnaire that ensured a standardized clinical assessment of these sleep-related complaints. Patient outcomes of fatigue, sleep, and exercise capacity parameters were compared with an age- and sex-adjusted control group.
Patients and methods
Study protocol
Consecutive patients were recruited from the outpatient clinic of the department of endocrinology in the Leiden University Medical Center, which is a tertiary referral center for HNP. A total of 105 consecutive patients with HNP were asked to participate in this study. The three questionnaires were sent to their homes in prepaid envelopes. Nonresponders were encouraged by phone to complete and return the questionnaires. Each patient was asked to provide a control person of comparable sex and age. In addition, for every patient, one age- and sex-matched control subject was derived from a database containing results of similar questionnaires in healthy controls in our center [19]. The medical ethics committee of the Leiden University Medical Center approved the study protocol.
Study parameters
Primary study parameters were the results of the three questionnaires. The results were linked to characteristics (age and gender) of the patients; the presence of carotid body tumors, number, size estimate, and location of HNP; surgical procedures; and clinical data. Tumor size was estimated by using the product of the two largest diameters on previous MRI, and patients were subsequently divided into two groups. As a cutoff value in tumor size estimate, we used 8 cm2.
Sleep questionnaires
Epworth Sleepiness Scale
The ESS is a validated self-administered questionnaire that has been proposed as a method for measuring daytime sleepiness in adults. The subject is asked to rate on a scale of 0 to 3 the chances he/she would doze in each of eight different situations that are commonly met in daily life (0 = would never doze, 3 = high chance of dozing). The ESS score is the sum of the eight items score and can range from 0 to 24. The normal range of ESS scores is 2–10 with a normal distribution. A score of 10 or more is considered increased [20, 21].
St. George Respiratory Questionnaire
The SGRQ is a validated self-administered questionnaire that has been proposed as a method for measuring health-related quality of life in chronic respiratory patients. It contains 50 items divided into three subscales: symptoms (8 items), activity (16 items), and disturbance of psychosocial function (26 items). Each item in the questionnaire has a weight attached, which provides an estimate of the distress associated with the symptom or state described. A score can be calculated for each subscale of the SGRQ, and also an overall score can be calculated. SGRQ scores range from 0 to 100, 0 score indicating no impairment of quality of life. A four-point change in SGRQ is considered a clinically significant difference [22].
Standard clinical assessment questionnaire
This questionnaire is frequently used in our hospital as a tool in clinical practice and research. Studies using this questionnaire have been published in peer-reviewed journals [23]. The standard clinical assessment questionnaire (SCAQ) may be used to screen patients for diseases which cause daytime sleepiness like: obstructive sleep apnea syndrome, depression, and restless legs syndrome. The SCAQ contains 12 yes/no items about snoring, loud and irregular snoring, environmental complaints about snoring, apnea, history of cardiovascular disease or hypertension, daytime sleepiness, refreshed when waking up, daytime fatigue, concentration difficulties, dyspnea or restless legs at night, and feelings of depression. In addition, three items on the assessment of bedtime, sleep onset, and rising time are present. Sleep duration and midsleep (clock time halfway during sleep duration) are calculated from sleep onset and rising time.
Statistics
SPSS for Windows version 12.0 (SPSS Inc., Chicago, IL) was used for data analysis. Data are expressed as percentages or as mean ± SD. We used chi-squared tests, unpaired T tests to compare patient and control data, and one-way analysis of variance (ANOVA) to compare several subgroups of patients, when appropriate. Independent variables affecting ESS and SGRQ scores were assessed by using linear regression analysis. These results were expressed as standardized β of independent predictive values. P < 0.05 was considered significant.
Results
Patients and controls
Characteristics of head-and-neck paraganglioma patients and controls
| Paraganglioma (n = 74) | Controls (n = 41) | Leiden controls (n = 74) | ||
|---|---|---|---|---|
| Age (years) | 49.1 ± 12.2 | 45.0 ± 11.4 | 52.2 ± 8.9 | |
| Sex (male/female) | 39/35 | 18/23 | 39/35 | |
| Height (m) | Male | 1.79 ± 0.06 | ||
| Female | 1.67 ± 0.08 | |||
| Weight (kg) | Male | 83 ± 14 | ||
| Female | 67 ± 12 | |||
| Body mass index | Male | 26 ± 4 | ||
| Female | 24 ± 5 | |||
| 1 glomus tumor | 29 (40%) | |||
| 2 glomus tumors | 17 (23%) | |||
| ≥3 glomus tumors | 27 (37%) | |||
| CBT without other GT | 29 (40%) | |||
| Bilateral CBT without other GT | 8 (11%) | |||
| Hearing loss | 26 (40%) | |||
| Tinnitus | 22 (34%) | |||
| Dysphonia | 12 (18%) | |||
| Dysphagia | 16 (25%) | |||
| Patients tested for mutation | 51 (69%) | |||
| SDH-D subunit (D92Y) mutation | 49 (66%) | |||
Of the paraganglioma patients, 40% had one glomus tumor, 23% had two glomus tumors, whereas 37% was diagnosed with three or more tumors. Carotid body tumors were found in 85% of the patients and more than half of these patients had been operated at some point during follow-up. In 40% of HNP patients, one or more carotid body tumors were apparent without the presence of other glomus tumors. In our study population, eight of these patients had bilateral carotid body tumors (11%). Sixty-one percent was classified as the larger tumor size estimate group. Intra-adrenal paragangliomas (pheochromocytomas) had previously been identified in 11 patients, whereas 2 patients were diagnosed with an extra-adrenal paraganglioma.
Complaints of hearing loss and tinnitus were present in 40% and 34% of the patients, respectively. Dysphonia was present in 18% the patients, and dysphagia was reported by 25% of the patients. Genetic analysis had been performed in 51 of 74 patients (69%). In 49 of these patients, an SDHD mutation was found (96%).
The 76 patients who returned the questionnaires provided 41 controls (54%). The control group (46% men) had a mean age of 45 ± 11 years. There were no significant differences in mean age and sex between patients and controls. For every patient one age- and sex-matched control subject was found in the database to create the larger control group (Leiden controls). The Leiden control group (53% men) had a mean age of 52 ± 9 years.
Sleep-related complaints in patients with HNP
Epworth Sleepiness Scale
Results of questionnaires in head-and-neck paraganglioma patients
| Paraganglioma (n = 74) | Controls (n = 41) | P value | Leiden controls (n = 74) | P value | |
|---|---|---|---|---|---|
| ESS | |||||
| Total score | 6.1 ± 4.1 | 5.7 ± 3.9 | 0.555 | 5.1 ± 3.5 | 0.092 |
| Total score ≥10 | 21% | 20% | 0.867 | 12% | 0.158 |
| SGRQ | |||||
| Symptoms score | 17.1 ± 19.3 | 12.2 ± 13.5 | 0.128 | ||
| Activity score | 15.4 ± 18.5 | 7.2 ± 9.9 | 0.007* | ||
| Disturbance of psychosocial function | 5.3 ± 10.5 | 1.2 ± 2.6 | 0.008* | ||
| Total score | 10.4 ± 12.9 | 5.0 ± 4.8 | 0.006* | ||
| SCAQ | |||||
| Snoring | 66% | 54% | 0.203 | 68% | 0.816 |
| Loud and irregular snoring | 37% | 35% | 0.865 | 33% | 0.637 |
| Complaints of environment | 30% | 30% | 0.988 | 29% | 0.881 |
| Apnea | 16% | 10% | 0.423 | 8% | 0.176 |
| Cardiovascular disease or hypertension | 45% | 24% | 0.032* | 37% | 0.348 |
| Daytime sleepiness | 39% | 25% | 0.137 | 27% | 0.127 |
| Waking up refreshed | 53% | 73% | 0.038* | 74% | 0.010* |
| Daytime fatigue | 51% | 24% | 0.006* | 28% | 0.006* |
| Concentration difficulties | 31% | 10% | 0.010* | 7% | 0.000* |
| Waking up at night by dyspnea | 14% | 0% | 0.014* | 5% | 0.092 |
| Restless legs | 34% | 12% | 0.012* | 22% | 0.098 |
| Feeling depressed | 19% | 2% | 0.012* | 4% | 0.005* |
| Sleep onset | 23:28 ± 0:50 | 23:21 ± 0:54 | 0.531 | 23:35 ± 0:58 | 0.390 |
| Sleep duration | 7:18 ± 1:06 | 7:14 ± 0:58 | 0.764 | 7:24 ± 0:58 | 0.517 |
| Midsleep | 3:06 ± 0:42 | 2:58 ± 0:38 | 0.317 | 3:18 ± 0:44 | 0.116 |
| Rising time | 6:44 ± 0:56 | 6:35 ± 0:41 | 0.410 | 7:00 ± 0:48 | 0.058 |
St. George Respiratory Questionnaire
The scores on three of the four subscales of the SGRQ were significantly increased in HNP patients. Activity, disturbance of psychosocial function, and total score were worse in patients compared to own controls (15.4 ± 18.5 vs. 7.2 ± 9.9, P = 0.007; 5.3 ± 10.5 vs. 1.2 ± 2.6, P = 0.008; and 10.4 ± 12.9 vs. 5.0 ± 4.8, P = 0.006). No difference was found in symptom scores. For this questionnaire we did not have an extended control group to include in our analyses, therefore these data are missing in Table 2.
Standard clinical assessment questionnaire
On the standard sleep questionnaire, patients reported more daytime fatigue, concentration difficulties, and symptoms of depression (51% vs. 24%, P = 0.006; 31% vs. 10%, P = 0.010; and 19% vs. 2%, P = 0.012, respectively). They also woke up less refreshed compared to both own controls and the extended control group (53% vs. 73%, P = 0.038 and 53% vs. 74%, P = 0.010, respectively). Dyspnea, restless legs, and history of cardiovascular disease or hypertension were increased as compared to the own control group (14% vs. 0%, P = 0.014; 34% vs. 12%, P = 0.012; and 45% vs. 24%, P = 0.032, respectively). However, in comparison to the Leiden control group, no differences were found. The percentage of patients with snoring, apnea, and daytime sleepiness was not significantly different in HNP patients compared to controls. Sleep onset, sleep duration, midsleep, and rising time were also reported equally.
Factors influencing daytime sleepiness in patients with HNP
Age
No significant correlations were found between age and ESS scores or between age and SGRQ scores. Age did increase complaints of dyspnea at night (β = 0.572, P = 0.024).
Gender
There were no significant correlations between gender and ESS scores or between gender and SGRQ scores. Women reported significantly more complaints of daytime fatigue and restless legs at night in the clinical assessment questionnaire (65% vs. 38%, P = 0.025 and 46% vs. 23%, P = 0.040, respectively). Men reported sleep apnea more often (29% vs. 0%, P = 0.001).
Dysphonia
Dysphonia was present in 18% of the patients. Dysphonia could not be related to a change in ESS scores. However, on the SGRQ, patients with dysphonia had worse symptoms, disturbance of psychosocial function, and total scores (31.8 ± 22.9 vs. 12.7 ± 16.6, P = 0.002; 12.8 ± 17.7 vs. 3.9 ± 8.6, P = 0.029; and 21.2 ± 21.7 vs. 8.4 ± 10.3, P = 0.010, respectively).
Number and estimated size of paragangliomas
Sixty percent of patients had multiple HNP. In addition to snoring and loud or irregular snoring on the standard clinical questionnaire (77% vs. 52%, P = 0.027 and 47% vs. 22%, P = 0.041), no other differences were present. The group with larger tumors tended to have more apnea (24% vs. 0%, P = 0.07) and a higher disturbance of psychosocial function (11.8 ± 16.9 vs. 2.5 ± 5.6, P = 0.05). However, the group with the smaller estimates of tumor size reported more daytime sleepiness and fatigue (29% vs. 71%, P = 0.01 and 41% vs. 79%, P = 0.03).
Carotid body tumors
Daytime sleepiness in patients with CBT compared to patients without CBT using ANOVA analysis
| No CBTa (n = 10) | Single CBTa (n = 35) | P value | Bilateral CBTa (n = 26) | P value | CBTb (n = 61) | P value | |
|---|---|---|---|---|---|---|---|
| ESS | |||||||
| Total score | 2.6 ± 2.0 | 6.6 ± 4.2 | 0.018* | 6.7 ± 4.0 | 0.019* | 6.6 ± 4.1 | 0.028* |
| Total ≥10 | 0% | 20% | 0.124 | 26.9% | 0.068 | 23% | 0.091 |
| SCAQ | |||||||
| Snoring | 40% | 62% | 0.222 | 82% | 0.012* | 71% | 0.054 |
| Apnea | 10% | 10% | 1 | 22.7% | 0.39 | 15% | 0.658 |
Recent catecholamine excess
In total, 14 patients had had at least one catecholamine-positive urine sample in the preceding year. No significant differences between patients with and without catecholamine excess were found in this study.
Surgery
Daytime sleepiness and sleep disorders in patients with surgical removal of a carotid body tumor
| Single CBT without surgery (n = 10) | Single CBT with surgery (n = 11) | P value | |
|---|---|---|---|
| ESS | |||
| Total score | 5.8 ± 4.7 | 7.7 ± 4.6 | 0.353 |
| Total score ≥10 | 20% | 27% | 0.696 |
| SCAQ | |||
| Snoring | 70% | 45% | 0.256 |
| Apnea | 22% | 11% | 0.466 |
| Restless legs | 30% | 27% | 0.890 |
Linear regression analysis (multivariate analysis)
Stepwise linear regression was performed in a model including age, gender, dysphonia, difficulties with swallowing, number of HNP, and the presence of carotid body tumors as independent variables and ESS scores and SGRQ scores as dependent variables. Age was an independent predictor of midsleep (β = 0.389, P = 0.005). Gender was not an independent predictor in this analysis. Dysphonia was found to be an independent predictor of symptoms, activity, disturbance of psychosocial function, and total scores of the SGRQ (β = 0.434, P = 0.001; β = 0.325, P = 0.043; β = 0.390, P = 0.015; and β = 0.434, P = 0.007, respectively). The presence of a carotid body tumor was an independent predictor of daytime sleepiness (β = 0.287, P = 0.029) according to the ESS questionnaire. Surgery was not found as an independent predictor.
Discussion
Synopsis of key findings
In this study we investigated daytime sleepiness, common sleep-related complaints, and exercise capacity in patients with HNP using questionnaires. Daytime fatigue, concentration difficulties, waking up less refreshed, and feelings of depression were found more often in HNP patients. Remarkably, daytime sleepiness was significantly increased in patients with one or more carotid body tumors, compared to patients without a carotid body tumor. Clinicians need to be aware that carotid bodies may have a distinct role in sleep-related complaints in these patients. However, based on the data of our study, we cannot exclude mechanical airway obstruction to have bearing on our results. Further detailed polysomnographic and ventilatory studies with arterial blood gas analyses in both pre- and postoperative patients would be helpful to further elucidate the pathophysiology.
Comparisons with other studies
Although several studies have investigated clinical presentations of HNP patients, data regarding sleep in these patients are limited. Recently, we performed a QoL study in HNP patients using validated general health-related questionnaires that reported an increase of fatigue and sleep disorders in these patients [15]. Therefore, in the present study, we included questionnaires that were more specifically designed to assess sleep-related complaints. Daytime fatigue, concentration difficulties, being less refreshed on waking up, and feelings of depression were reported to be worse in patients as compared to controls, thus suggesting an association of HNP and/or its treatment with sleep-related disorders. Dysphonia was found to be an independent predictor of symptoms, disturbance of psychosocial function, and total scores according to the SGRQ, which is concordant with our results in the QoL study.
In HNP patients with one or more carotid body tumors, total scores on daytime sleepiness were significantly higher compared to patients without carotid body tumors. However, using the ESS score of 10 or higher as a cutoff value, a significant difference was only found in patients with bilateral carotid body tumors. In the literature, case reports have been published suggesting associations between carotid body tumors and sleep apnea or hypoventilation [2, 24, 25, 26, 27]. Reports have been published describing obstructive sleep apnea syndrome caused by the presence of carotid body tumors with (partial) relief after surgical removal [24, 26]. On the other hand, the development of an abnormal hypoxic ventilatory drive and hypoventilation syndromes after the surgical removal of (bilateral) carotid body tumors has been reported as well [2, 27, 28]. In our study, no significant results concerning the effects of surgery could be found; however, this might be due to the small number of patients that had been operated in our cohort. The percentage of paraganglioma patients in the present study that reported sleep apnea was not significantly increased in comparison with controls. However, in the present study, apnea was only assessed by using self-reported questionnaires and many patients and controls did not know whether or not they had sleep apnea. In addition, although we did not have the exact tumor volumes, our data suggest that sleep apnea may be more commonly found in those patients who have larger tumors. Considering these observations and the increased daytime sleepiness in patients with carotid body tumors, the results of our study warrant additional sleep apnea studies, like polysomnography, in addition to these self-reported questionnaires.
We did not find a correlation between age and sleepiness by univariate analysis, which is in contrast with findings in the general healthy population [29, 30]. This discrepancy could be due to the limited age range of the subjects included in our study. In the multivariate regression analysis, age was an independent predictor of midsleep. In this study patients were compared with own controls and controls derived from previous studies performed in this hospital. The advantage of using own controls is that they are from the same geographic area and socioeconomic class as the patients [31]. However, there may be a selection bias, because patients could have chosen subjects with a good health status [32]. In addition, a considerable number of control subjects chose to return the questionnaires unanswered, resulting in a relatively small number of own controls. Therefore, for every patient, one age- and sex-matched control subject was derived from a database containing results of similar questionnaires, except for the SGRQ results, in healthy controls in our center.
Respiratory drive during non-rapid eye movement sleep is mainly influenced by the metabolic (autonomic) control system, and therefore chemoreceptors alone may be responsible for providing effective input to the respiratory center in the brain stem [1, 3, 4, 6, 7, 18, 33]. The carotid body is the most powerful peripheral chemoreceptor sensitive mainly to arterial oxygen tension. In response to hypoxia, the firing rate of chemosensory impulses increases in the carotid sinus nerve. The impulses reach the respiratory center in the brain stem via the glossopharyngeal nerve, resulting in an increase in ventilation. In HNP patients the function of these peripheral chemoreceptors may be disturbed, either in the carotid body tumor itself or adjacent nerves. Ventilatory responses to hypoxia may be less adequate [4, 16, 24, 28, 33, 34]. Our results suggest that patients with carotid body tumors have more complaints of daytime sleepiness than patients without carotid body tumors. Thus, we could hypothesize that disturbed chemoreceptor function in HNP patients might be contributory to increased daytime sleepiness, especially in those with carotid body tumors.
Clinical applicability of the study
Of course the hypothesis that dysfunction and/or removal of these carotid bodies (that play a role in controlling breathing) are directly responsible for the impaired sleep is appealing. However, since we did not specifically investigate airway resistance in our study, we were not able to estimate the contribution of a purely mechanical obstruction of the upper airways to the reported complaints. The dilator muscles of the upper airway have been shown to play a critical role in maintaining patency of the oropharynx during inspiration [35]. Obstructive sleep apnea has been shown to occur in patients with inadequate activity of the glenioglossus, the main protrusor muscle of the tongue [36]. Neural output to the glenioglossus is stimulated largely by input from the peripheral chemoreceptors [37, 38]. This might be of critical importance to the control of the airway resistance in patients who have undergone surgical removal of carotid bodies. Importantly, larger paragangliomas in situ may also cause direct compression of the upper airway. Interestingly, albeit not significantly, sleep apnea tended to be more frequent in the group with the larger tumors. Unfortunately, we could not precisely calculate tumor volume and did not perform additional studies. This remains to be further analyzed in future studies.
In conclusion, we found self-reported, sleep-related problems to be increased in HNP patients. Remarkably, patients with carotid body tumors had increased daytime sleepiness compared to patients without carotid body tumors. Clinicians need to be aware that carotid bodies may have a distinct role in sleep-related complaints in these patients. However, based on the data of our study, we cannot exclude mechanical airway obstruction to have bearing on our results. Further detailed polysomnographic and ventilatory studies with arterial blood gas analyses in both pre- and postoperative patients would be helpful to further elucidate the pathophysiology.
Notes
Open Access
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