Sleep and Breathing

, Volume 15, Issue 2, pp 195–201

The efficacy of oral appliances in the treatment of severe obstructive sleep apnea

  • Bing Lam
  • Kim Sam
  • Jamie C. M. Lam
  • Agnes Y. K. Lai
  • Chi-Leung Lam
  • Mary S. M. Ip
Original Article

DOI: 10.1007/s11325-011-0496-y

Cite this article as:
Lam, B., Sam, K., Lam, J.C.M. et al. Sleep Breath (2011) 15: 195. doi:10.1007/s11325-011-0496-y

Abstract

Objectives

The purpose of this study is to evaluate the efficacy of oral appliance (OA) treatment for subjects with severe obstructive sleep apnea (OSA) and to determine the dental parameters associated with treatment outcomes.

Study design

This study uses a prospective longitudinal design.

Methods

Consecutive Chinese subjects with severe OSA who refused continuous positive airway pressure treatment were recruited. Their dental measurements were taken from lateral cephalometric radiographs. Polysomnograms with OA were repeated at 3 months and 1 year. Blood pressure was taken in the morning after sleep studies.

Results

Thirty-four subjects were evaluated at 3 months and 1 year according to the principle of intention-to-treat analysis. OA reduced AHI significantly in subjects with favorable responses, from 49.3 (37.4–67) to 12.5 (6.1–15.7), p < 0.001 at 3 months and from 47.5 (41.1–72.9) to 13.1 (6.0–14.0), p < 0.001 at 1 year. These OSA subjects had an increased overjet at baseline compared to those with unfavorable responses (p ≤ 0.05). Systolic blood pressure was significantly reduced in those hypertensive OSA subjects after 3 months and 1 year of treatment.

Conclusions

OA reduces the severity of sleep apnea, and the effect is maintained at 1 year in subjects with retrognathism. OA appears to reduce systolic blood pressure in hypertensive OSA subjects at 3 months and 1 year.

Keywords

Oral appliances Severe obstructive sleep apnea Retrognathism Blood pressure 

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Bing Lam
    • 1
  • Kim Sam
    • 2
  • Jamie C. M. Lam
    • 1
  • Agnes Y. K. Lai
    • 1
  • Chi-Leung Lam
    • 1
  • Mary S. M. Ip
    • 1
  1. 1.Department of Medicine, Queen Mary HospitalThe University of Hong KongHong Kong SARChina
  2. 2.Orthodontics, Faculty of DentistryThe University of Hong KongHong Kong SARChina

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