Sleep and Breathing

, Volume 15, Issue 3, pp 579–587 | Cite as

The effect of nasal continuous positive airway pressure on the symptoms of Gulf War illness

  • Mohammad M. AminEmail author
  • Morris S. Gold
  • Joan E. Broderick
  • Avram R. Gold
Original Article



We performed a pilot study to determine whether nasal continuous positive airway pressure (CPAP) alleviates the symptoms of veterans with Gulf War illness (GWI) and sleep disordered breathing (SDB).


Eighteen male veterans with GWI and SDB recruited by advertisement, participated in a randomized, single-masked, sham-controlled treatment trial. Participants received 3 weeks of treatment during sleep with either therapeutic nasal CPAP or sham nasal CPAP. Using validated questionnaires, pain, fatigue, cognitive function, sleep disturbance, and general health were assessed by self-report before and after treatment. One of the participants assigned to therapeutic CPAP was excluded from the trial before starting treatment, leaving 17 participants.


Compared to the nine sham nasal CPAP recipients, the eight participants receiving therapeutic nasal CPAP experienced improvements in pain (34%; p = 0.0008), fatigue (38%; p = 0.0002), cognitive function (33%; p = 0.004), sleep quality (41%; p = 0.0003), physical health (34%; p = 0.0003), and mental health (16%; p = 0.03).


Our findings in this pilot study suggest that nasal CPAP may greatly improve symptoms in veterans with GWI and SDB.


Gulf war illness Functional somatic syndromes Nasal continuous positive airway pressure Sleep disordered breathing Sleep stage shifts 



Dr. Amin is a recipient of a Department of Veterans Affairs Career Development Award.

Dr. Morris Gold's participation in this study was entirely voluntary. Novartis Consumer Health provided no funding or other resources for this study.

Respironics Inc. supplied, at no cost, all of the nasal CPAP hardware and software for this study.

Conflicts of interest

The authors acknowledge no conflicts of interest.


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Copyright information

© © US Government 2010

Authors and Affiliations

  • Mohammad M. Amin
    • 1
    Email author
  • Morris S. Gold
    • 3
  • Joan E. Broderick
    • 2
  • Avram R. Gold
    • 1
  1. 1.Division of Pulmonary/Critical Care/Sleep Medicine, (111D)DVA Medical CenterNorthportUSA
  2. 2.Department of Psychiatry and Behavioral SciencesStony Brook University School of MedicineStony BrookUSA
  3. 3.Novartis Consumer HealthParsippanyUSA

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