How common is sleep-disordered breathing in patients with idiopathic pulmonary fibrosis?
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Background and aim
The frequency of obstructive sleep apnea–hypopnea syndrome (OSAHS) in patients with idiopathic pulmonary fibrosis (IPF) remains controversial. The aim of this study was to assess the frequency of OSAHS in newly diagnosed IPF patients and to identify possible correlations with body mass index and pulmonary function testing parameters.
Materials and methods
Thirty-four newly diagnosed IPF patients were included. All subjects underwent attended overnight PSG. None of the included subjects was under any of the currently available IPF treatments or nocturnal supplemental oxygen therapy.
Total apnea–hypopnea index (AHI) was <5, 5–15, and ≥15/h of sleep in 14 (41%), 15 (44%), and five patients (15%), respectively. REM AHI was statistically significant correlated with TLC [Total lung capacity] (p = 0.03, r = −0.38). Diffusing capacity of the lung for carbon monoxide was correlated with mean oxygen saturation during sleep (p = 0.02, r = 0.39).
Sleep-disordered breathing seems frequent, although remains usually under diagnosed in IPF patients. A decrease in TLC, reflecting the severity of pulmonary restriction, might predispose IPF patients in SDB, especially during the vulnerable REM sleep period.
KeywordsIdiopathic pulmonary fibrosis (IPF) Polysomnography (PSG) Obstructive sleep apnea–hypopnea syndrome (OSAHS)
- 1.American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. Am J Respir Crit Care Med 2002;165: 277–304.Google Scholar
- 2.Idiopathic Pulmonary Fibrosis: Diagnosis and Treatment. International Consensus Statement. Am J Respir Crit Care Med 2000;161:646–64.Google Scholar
- 9.American Academy of Sleep Medicine (1999) Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research; the report of the American Academy of Sleep Medicine task force. Sleep 22:667–89Google Scholar
- 10.American Academy of Sleep Medicine. The AASM Manual for the scoring of sleep and associated events. Rules, Terminology and Technical Specifications. AASM 2007Google Scholar
- 11.American Thoracic Society (1995) Standardization of spirometry, 1994 update. Am J Respir Crit Care Med 152:1107–36Google Scholar