Sleep and Breathing

, Volume 14, Issue 4, pp 387–390

How common is sleep-disordered breathing in patients with idiopathic pulmonary fibrosis?

  • Charalampos Mermigkis
  • Eleni Stagaki
  • Stavros Tryfon
  • Sophia Schiza
  • Anastasia Amfilochiou
  • Vlassios Polychronopoulos
  • Panagiotis Panagou
  • Nikolaos Galanis
  • Anastasios Kallianos
  • Demetrios Mermigkis
  • Antony Kopanakis
  • Georgios Varouchakis
  • Fotis Kapsimalis
  • Demosthenis Bouros
Short Communication

Abstract

Background and aim

The frequency of obstructive sleep apnea–hypopnea syndrome (OSAHS) in patients with idiopathic pulmonary fibrosis (IPF) remains controversial. The aim of this study was to assess the frequency of OSAHS in newly diagnosed IPF patients and to identify possible correlations with body mass index and pulmonary function testing parameters.

Materials and methods

Thirty-four newly diagnosed IPF patients were included. All subjects underwent attended overnight PSG. None of the included subjects was under any of the currently available IPF treatments or nocturnal supplemental oxygen therapy.

Results

Total apnea–hypopnea index (AHI) was <5, 5–15, and ≥15/h of sleep in 14 (41%), 15 (44%), and five patients (15%), respectively. REM AHI was statistically significant correlated with TLC [Total lung capacity] (p = 0.03, r = −0.38). Diffusing capacity of the lung for carbon monoxide was correlated with mean oxygen saturation during sleep (p = 0.02, r = 0.39).

Conclusions

Sleep-disordered breathing seems frequent, although remains usually under diagnosed in IPF patients. A decrease in TLC, reflecting the severity of pulmonary restriction, might predispose IPF patients in SDB, especially during the vulnerable REM sleep period.

Keywords

Idiopathic pulmonary fibrosis (IPF) Polysomnography (PSG) Obstructive sleep apnea–hypopnea syndrome (OSAHS) 

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Charalampos Mermigkis
    • 1
  • Eleni Stagaki
    • 3
  • Stavros Tryfon
    • 2
  • Sophia Schiza
    • 4
  • Anastasia Amfilochiou
    • 3
  • Vlassios Polychronopoulos
    • 3
  • Panagiotis Panagou
    • 1
  • Nikolaos Galanis
    • 2
  • Anastasios Kallianos
    • 1
  • Demetrios Mermigkis
    • 3
  • Antony Kopanakis
    • 3
  • Georgios Varouchakis
    • 1
  • Fotis Kapsimalis
    • 1
  • Demosthenis Bouros
    • 5
  1. 1.Sleep Disorders Center401 General Army HospitalAthensGreece
  2. 2.1st Pulmonary ClinicG.H. “G. Papanikolaou”ThessalonikiGreece
  3. 3.Third Pulmonary DepartmentSismanoglion General District HospitalAthensGreece
  4. 4.Sleep Disorders Unit, Department of Thoracic Medicine, Medical SchoolUniversity of CreteHeraklionGreece
  5. 5.Department of PneumonologyDemocritus Medical School University of ThraceAlexandroupolisGreece

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