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Special considerations for obstructive sleep apnea in women

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To the editor,

I read with interest the article by Dursunoglu et al. exploring the differences in the clinical presentation between men and women with obstructive sleep apnea (OSA) admitted to the sleep clinic [1]. The authors compared a number of variables including age between both groups (men and women) without exploring the menopausal status of women. With regards to women, including age without considering the menopausal status can be misleading. In females, the menopausal status is one of the most important risk factors and predictors of OSA regardless of age and body mass index (BMI), and its assessment is an essential part of any study looking into OSA in women. Young et al. assessed the association between the menopausal status and sleep-disordered breathing in women [2]. After adjusting for potential confounders like age, BMI, and smoking, the authors calculated the odds ratio (95% CI) for an apnea hypopnea index (AHI) of more than five per hour of sleep to be 1.2 (0.7-2.02) in perimenopausal and 2.6 (1.4-4.8) in the postmenopausal women [2]. Some studies have suggested that sleep differences between men and women become less obvious in postmenopausal compared to premenopausal women [3, 4]. After menopause, the prevalence and severity of OSA in women approach that in men [2, 3, 5]. On the contrary, the AHI in premenopausal women is usually less than that in men [3]. Furthermore, women are more likely to exhibit apneas during rapid eye movement (REM) sleep [6, 7]. Dursunoglu et al. did not report the distribution of apnea in REM and nonREM sleep [1]. Women tend to have higher REM-related apnea than men. This was studied by O’ Conner who found that most of the respiratory events in women occurred during REM sleep and 62% of women were categorized as REM-related apnea group compared to 24% of men [8]. This difference was not age or weight dependent [8]. Hence, it appears that women can be symptomatic at a lower AHI, possibly due to clustering of apneas and hypopneas mainly in REM sleep [4, 9].

References

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Correspondence to Ahmed Salem BaHammam.

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The author has no personal or financial support or author involvement with organization(s) with financial interest in the subject matter or any conflict of interest to report.

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BaHammam, A.S. Special considerations for obstructive sleep apnea in women. Sleep Breath 14, 175 (2010). https://doi.org/10.1007/s11325-009-0303-1

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Keywords

  • Obstructive sleep apnea
  • Menopause
  • Rapid eye movement sleep