Sleep and Breathing

, Volume 13, Issue 1, pp 85–88 | Cite as

Urinary levels of catecholamines among individuals with and without sleep bruxism

  • Paula Seraidarian
  • Paulo Isaías Seraidarian
  • Bruno das Neves Cavalcanti
  • Leonardo MarchiniEmail author
  • Ana Christina Claro Neves
Original Article



Sleep bruxism (SB) is characterized by repetitive and coordinated mandible movements and non-functional teeth contacts during sleep time. Although the etiology of SB is controversial, the literature converges on its multifactorial origin. Occlusal factors, smoking, alcoholism, drug usage, stress, and anxiety have been described as SB trigger factors. Recent studies on this topic discussed the role of neurotransmitters on the development of SB.


Thus, the purpose of this study was to detect and quantify the urinary levels of catecholamines, specifically of adrenaline, noradrenaline and dopamine, in subjects with SB and in control individuals.

Materials and methods

Urine from individuals with SB (n = 20) and without SB (n = 20) was subjected to liquid chromatography. The catecholamine data were compared by Mann–Whitney’s test (p ≤ 0.05).


Our analysis showed higher levels of catecholamines in subjects with SB (adrenaline = 111.4 µg/24 h; noradrenaline = 261,5 µg/24 h; dopamine = 479.5 µg/24 h) than in control subjects (adrenaline = 35,0 µg/24 h; noradrenaline = 148,7 µg/24 h; dopamine = 201,7 µg/24 h). Statistical differences were found for the three catecholamines tested.


It was concluded that individuals with SB have higher levels of urinary catecholamines.


Sleep bruxism Etiology Catecholamines Adrenaline Noradrenaline Dopamine Urine 


  1. 1.
    Lavigne GJ, Kato T, Kolta A, Sessle BJ (2003) Neurobiological mechanisms involved in sleep bruxism. Crit Rev Oral Biol Med 14:30–46CrossRefPubMedGoogle Scholar
  2. 2.
    Lavigne GJ, Rompré PH, Poirierl G, Huard H, Katol T, Montplaisir JY (2001) Rhythmic masticatory muscle activity during sleep in humans. J Dent Res 80:443–448CrossRefPubMedGoogle Scholar
  3. 3.
    Lobbezoo F, Naeije M (2001) Bruxism is mainly regulated centrally, not peripherally. J Oral Rehabil 28:1085–1091CrossRefPubMedGoogle Scholar
  4. 4.
    Amir I, Hermesh H, Gavish A (1997) Bruxism secondary to antipsychotic drug exposure: a positive response to propranolol. Clin Neuropharmacol 20:86–89CrossRefPubMedGoogle Scholar
  5. 5.
    Bader G, Lavigne GJ (2000) Sleep bruxism: overview of an oromandibular sleep movement disorder. Sleep Med Rev 4:27–43CrossRefPubMedGoogle Scholar
  6. 6.
    Lobbezoo F, Soucy JP, Hartman NG, Montplaisir JY, Lavigne GJ (1997) Effects of the D2 receptor agonist bromocriptine on sleep bruxism: report of two single patient trials. J Dent Res 76:1610–1614CrossRefPubMedGoogle Scholar
  7. 7.
    Bostwick JM, Jaffee MS (1999) Buspirone as an antidote to SSRI-induced bruxism in 4 cases. J Clin Psychiatry 60:857–860CrossRefPubMedGoogle Scholar
  8. 8.
    Brown ES, Hong SC (1999) Antidepressant-induced bruxism successfully treated with gabapentin. J Am Dent Assoc 130:1467–1469PubMedGoogle Scholar
  9. 9.
    Micheli F, Pardal MF, Gatto M, Asconapé J, Giannaula R, Parera IC (1993) Bruxism secondary to chronic antidopaminergic drug exposure. Clin Neuropharmacol 16:315CrossRefPubMedGoogle Scholar
  10. 10.
    Ohayon MM, Li KK, Guilleminault C (2001) Risk factors for sleep bruxism in the general population. Chest 119:53–61CrossRefPubMedGoogle Scholar
  11. 11.
    Patrick R (2004) Selective serotonin reuptake inhibitors (SSRI) and bruxism. Focus Journal for Respir Care Sleep Med Fall:14–21Google Scholar
  12. 12.
    Stein DJ, Van Greunen G, Niehaus D (1998) Can bruxism respond to serotonin reuptake inhibitors? J Clin Psychiatry 59(3):133CrossRefPubMedGoogle Scholar
  13. 13.
    Winocur E, Gavish A, Voikovitch M, Emodi-Perlman A, Eli I (2003) Drugs and bruxism: a critical review. J Orofac Pain 17:99–111PubMedGoogle Scholar
  14. 14.
    Lobbezoo F, Lavigne GJ, Tanguay R, Montplaisir JY (1997) The effect of catecholamine precursor l-Dopa on sleep bruxism: a controlled clinical trial. Mov Disord 12:73–78CrossRefPubMedGoogle Scholar
  15. 15.
    Sjöholm T, Lehtinen I, Piha SJ (1996) The effect of propanolol on sleep bruxism hypothetical considerations based on a case study. Clin Auton Res 6:37–40CrossRefPubMedGoogle Scholar
  16. 16.
    Chen WH, Lu YC, Lui CC, Liu JS (2005) A proposed mechanism for diurnal/nocturnal bruxism: hypersensitiviy of presynaptic dopamine receptors in the frontal lobe. J Clin Neurosci 12:161–163CrossRefPubMedGoogle Scholar
  17. 17.
    Clark GT, Rugh JD, Handelman SL (1980) Nocturnal masseter muscle activity and urinary catecholamine levels in bruxers. J Dent Res 59:1571–1576CrossRefPubMedGoogle Scholar
  18. 18.
    Magee KR (1970) Bruxism related to levodopa therapy. J Am Med Assoc 214:147CrossRefGoogle Scholar
  19. 19.
    Areso MP, Giralt MT, Sainz B, Prieto M, Garcia-Vallejo P, Gomez FM (1999) Occlusal disharmonies modulate central catecholaminergic activity in the rat. J Dent Res 78:1204–1213CrossRefPubMedGoogle Scholar
  20. 20.
    Gomez FM, Giralt MT, Sainz B, Arrue A, Prieto M, Garcia-Vallejo P (1999) A possible attenuation of stress-induced increases in striatal dopamine metabolism by the expression of non-functional masticatory activity in the rat. Eur J Oral Sci 107:461–467CrossRefPubMedGoogle Scholar
  21. 21.
    Vanderas AP, Menenakou M, Kouimtzis T, Papagiannoulis L (1999) Urinary catecholamine levels and bruxism in children. J Oral Rehabil 26:103–110CrossRefPubMedGoogle Scholar
  22. 22.
    Wetter TC, Stiasny K, Winkelmann J, Buhlinger A, Brandenburg U, Penzel T et al (1999) A randomized controlled study of pergolide in patients with restless legs syndrome. Neurology 52:944–950PubMedGoogle Scholar
  23. 23.
    American Academy of Sleep Medicine (2001) International classification of sleep disorders, revised: diagnostic and coding manual. American Academy of Sleep Medicine, ChicagoGoogle Scholar
  24. 24.
    Ross GA, Newbould EC, Thomas J, Bouloux PM, Besser GM, Perrett D et al (1993) Plasma and 24 h-urinary catecholamine concentrations in normal and patient populations. Ann Clin Biochem 30:38–44PubMedGoogle Scholar
  25. 25.
    Osterberg T, Carlsson G (2007) Relationship between symptoms of temporomandibular disorders and dental status, general health and psychosomatic factors in two cohorts of 70-year-old subjects. Gerodontol 24:129–135CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Paula Seraidarian
    • 1
  • Paulo Isaías Seraidarian
    • 2
  • Bruno das Neves Cavalcanti
    • 1
    • 3
  • Leonardo Marchini
    • 1
    • 4
    • 5
    • 6
    Email author
  • Ana Christina Claro Neves
    • 1
  1. 1.Universidade de TaubatéTaubatéBrazil
  2. 2.Pontifícia Universidade Católica de Minas GeraisBelo HorizonteBrazil
  3. 3.Universidade IbirapueraSão PauloBrazil
  4. 4.Universidade do Vale do ParaíbaSão José dos CamposBrazil
  5. 5.State University of São Paulo-UNESPSão José dos CamposBrazil
  6. 6.S.J. CamposBrazil

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