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Physiological Whole-Brain Distribution of [18F]FDOPA Uptake Index in Relation to Age and Gender: Results from a Voxel-Based Semi-quantitative Analysis

  • Sinn-Rithy Toch
  • Sylvain Poussier
  • Emilien Micard
  • Marc Bertaux
  • Axel Van Der Gucht
  • Elodie Chevalier
  • Pierre-Yves Marie
  • Eric Guedj
  • Antoine Verger
Research Article
  • 35 Downloads

Abstract

Purpose

6-[18F]fluoro-l-DOPA ([18F]FDOPA), a positron emission tomography (PET) amino-acid tracer of brain decarboxylase activity, is used to assess the brain dopaminergic system. Using a voxel-based semi-quantitative analysis, this study aimed to determine whether a current brain uptake index of [18F]FDOPA, expressed relative to the occipital background level, varies according to age and gender.

Procedures

One hundred and seventy-seven subjects were retrospectively included. A whole-brain statistical parametric mapping analysis of the [18F]FDOPA uptake index in parametric PET images was performed at a voxel threshold of p < 0.05 (corrected) and p < 0.005 (uncorrected, k cluster > 125).

Results

Striatal uptake indices were influenced by age, negatively for the caudate nucleus and positively for the putamen, as well as by gender, with a lower left putaminal uptake index in women. Extra-striatal uptake indices were influenced by age, negatively for the frontal cortex and brainstem and positively for the occipital cortex and cerebellum, as well as by gender (diffuse increase in women).

Conclusions

The uptake index of [18F]FDOPA exhibited significant physiological variations according to age and gender and should therefore be considered for PET interpretation.

Key words

[18F]FDOPA PET Quantitative analysis Age Gender Template 

Notes

Acknowledgements

The authors thank Pierre Pothier for the critical review of the manuscript.

Compliance with Ethical Standards

This retrospective study was approved on June 27, 2017 by the local institutional review board (IRB) and the Ethics Committee (CPP Est III).

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

For this type of study, formal consent is not required. Informed consent was obtained from all individual participants included in the study.

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Copyright information

© World Molecular Imaging Society 2018

Authors and Affiliations

  • Sinn-Rithy Toch
    • 1
  • Sylvain Poussier
    • 1
    • 2
  • Emilien Micard
    • 2
  • Marc Bertaux
    • 3
  • Axel Van Der Gucht
    • 4
  • Elodie Chevalier
    • 1
  • Pierre-Yves Marie
    • 1
    • 5
  • Eric Guedj
    • 6
    • 7
    • 8
  • Antoine Verger
    • 1
    • 2
  1. 1.Department of Nuclear Medicine & Nancyclotep Imaging Platform, CHRU NancyLorraine UniversityNancyFrance
  2. 2.Lorraine University, INSERM, IADINancyFrance
  3. 3.Department of Nuclear MedicineAPHP Pitié SalpêtrièreParisFrance
  4. 4.Departments of Nuclear Medicine and Molecular ImagingLausanne University HospitalLausanneSwitzerland
  5. 5.INSERM, UMR 1116Lorraine UniversityNancyFrance
  6. 6.Aix Marseille Univ, CNRS, Centrale Marseille, Institut FresnelMarseilleFrance
  7. 7.Department of Biophysics & Nuclear MedicineAPHM TimoneMarseilleFrance
  8. 8.European Research Center in Nuclear Medicine, CERIMEDMarseilleFrance

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