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Molecular Imaging and Biology

, Volume 20, Issue 4, pp 632–640 | Cite as

Diffusion Profiling via a Histogram Approach Distinguishes Low-grade from High-grade Meningiomas, Can Reflect the Respective Proliferative Potential and Progesterone Receptor Status

  • Georg Alexander Gihr
  • Diana Horvath-Rizea
  • Nikita Garnov
  • Patricia Kohlhof-Meinecke
  • Oliver Ganslandt
  • Hans Henkes
  • Hans Jonas Meyer
  • Karl-Titus Hoffmann
  • Alexey Surov
  • Stefan Schob
Research Article

Abstract

Purpose

Presurgical grading, estimation of growth kinetics, and other prognostic factors are becoming increasingly important for selecting the best therapeutic approach for meningioma patients. Diffusion-weighted imaging (DWI) provides microstructural information and reflects tumor biology. A novel DWI approach, histogram profiling of apparent diffusion coefficient (ADC) volumes, provides more distinct information than conventional DWI. Therefore, our study investigated whether ADC histogram profiling distinguishes low-grade from high-grade lesions and reflects Ki-67 expression and progesterone receptor status.

Procedures

Pretreatment ADC volumes of 37 meningioma patients (28 low-grade, 9 high-grade) were used for histogram profiling. WHO grade, Ki-67 expression, and progesterone receptor status were evaluated. Comparative and correlative statistics investigating the association between histogram profiling and neuropathology were performed.

Results

The entire ADC profile (p10, p25, p75, p90, mean, median) was significantly lower in high-grade versus low-grade meningiomas. The lower percentiles, mean, and modus showed significant correlations with Ki-67 expression. Skewness and entropy of the ADC volumes were significantly associated with progesterone receptor status and Ki-67 expression. ROC analysis revealed entropy to be the most accurate parameter distinguishing low-grade from high-grade meningiomas.

Conclusions

ADC histogram profiling provides a distinct set of parameters, which help differentiate low-grade versus high-grade meningiomas. Also, histogram metrics correlate significantly with histological surrogates of the respective proliferative potential. More specifically, entropy revealed to be the most promising imaging biomarker for presurgical grading. Both, entropy and skewness were significantly associated with progesterone receptor status and Ki-67 expression and therefore should be investigated further as predictors for prognostically relevant tumor biological features. Since absolute ADC values vary between MRI scanners of different vendors and field strengths, their use is more limited in the presurgical setting.

Key Words

Meningiomas Diffusion-weighted imaging Histogram analysis Histopathology Imaging biomarker 

Notes

Compliance with Ethical Standards

The study was approved by the ethics committee of the medical council of Baden-Württemberg (Ethik-Kommission Landesärztekammer Baden-Württemberg, F-2017-047).

Conflict of Interest

The authors declare that they have no conflict of interest.

Funding Information

This study acknowledges funding via the Clinician-Scientist-Program of the medical faculty of the University Hospital Leipzig.

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Copyright information

© World Molecular Imaging Society 2018

Authors and Affiliations

  • Georg Alexander Gihr
    • 1
  • Diana Horvath-Rizea
    • 1
  • Nikita Garnov
    • 2
  • Patricia Kohlhof-Meinecke
    • 3
  • Oliver Ganslandt
    • 4
  • Hans Henkes
    • 1
  • Hans Jonas Meyer
    • 5
  • Karl-Titus Hoffmann
    • 6
  • Alexey Surov
    • 5
  • Stefan Schob
    • 6
  1. 1.Clinic for NeuroradiologyKatharinenhospital StuttgartStuttgartGermany
  2. 2.Eichamt LeipzigLeipzigGermany
  3. 3.Department for PathologyKatharinenhospital StuttgartStuttgartGermany
  4. 4.Neurosurgical ClinicKatharinenhospital StuttgartStuttgartGermany
  5. 5.Clinic for Diagnostic and Interventional RadiologyUniversity Hospital LeipzigLeipzigGermany
  6. 6.Department for NeuroradiologyUniversity Hospital LeipzigLeipzigGermany

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