Suboptimal Sensitivity and Specificity of PET and Other Gross Imaging Techniques in Assessing Lymph Node Metastasis

  • Abass AlaviEmail author
  • Sean D. Carlin
  • Thomas J. Werner
  • Abdullah Al-Zaghal

In recent years, we have emphasized the limitations of positron emission tomography (PET) in imaging disorders that are beyond the capability of current instruments and available radiotracers [1, 2, 3, 4, 5, 6]. These include imaging islets, bacteria, plaques and tangles, and atherosclerotic plaques. The spatial resolution of PET has substantially improved over the past decade, and therefore, high-quality images can be generated, particularly with specialized instruments for brain and animal studies. However, when the spatial resolution of PET instruments that are designed to image the entire body compared to that of dedicated brain scanners, it becomes quite evident that image quality deteriorates substantially due to large field of view and volume of the structures assessed. In other words, specially designed PET scanners for the brain (and possibly other small organs such as the breast) can provide images with spatial resolutions at around 4–5 mm that are similar to that of phantom...

Key words

Malignancy Cancer Lymph node metastasis PET Limitations Staging 


Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.


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Copyright information

© World Molecular Imaging Society 2019

Authors and Affiliations

  1. 1.Department of RadiologyHospital of the University of PennsylvaniaPhiladelphiaUSA

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