Molecular Imaging and Biology

, Volume 19, Issue 3, pp 357–362 | Cite as

Optical Surgical Navigation for Precision in Tumor Resections

  • Stefan Harmsen
  • Nutte Teraphongphom
  • Michael F. Tweedle
  • James P. Basilion
  • Eben L. RosenthalEmail author
Special Topic


Optical imaging methods have significant potential as effective intraoperative tools to visualize tissues, cells, and biochemical events aimed at objective assessment of the tumor margin and guiding the surgeon to adequately resect the tumor while sparing critical tissues. The wide variety of approaches to guide resection, the range of parameters that they detect, and the interdisciplinary nature involving biology, chemistry, engineering, and medicine suggested that there was a need for an organization that could review, discuss, refine, and help prioritize methods to optimize patient care and pharmaceutical and instrument development. To address these issues, the World Molecular Imaging Society created the Optical Surgical Navigation (OSN) interest group to bring together scientists, engineers, and surgeons to develop the field to benefit patients. Here, we provide an overview of approaches currently under clinical investigation for optical surgical navigation and offer our perspective on upcoming strategies.

Key words

Optical navigation Surgery Image guidance Probes Oncology 


Author Contribution

S.H. and N.T. wrote the manuscript. M.F.T., J.P.B., and E.L.R. wrote and revised the manuscript. All authors reviewed and approved the manuscript.

Compliance with Ethical Standards

Conflict of Interests

S.H., N.T., M.F.T., and E.L.R. declare no conflicts of interests. J.P.B. has an interest in Akrotome Imaging Inc., a company developing probes in this space, and consults for Vergent Biosciences and LightPoint Medical Ltd.


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Copyright information

© World Molecular Imaging Society 2017

Authors and Affiliations

  • Stefan Harmsen
    • 1
  • Nutte Teraphongphom
    • 2
  • Michael F. Tweedle
    • 3
  • James P. Basilion
    • 4
    • 5
    • 6
  • Eben L. Rosenthal
    • 7
    • 8
    Email author
  1. 1.Department of PediatricsStanford UniversityStanfordUSA
  2. 2.Department of Otolaryngology—Head and Neck SurgeryStanford UniversityStanfordUSA
  3. 3.Department of Radiology, The Wright Center for Innovation in Biomedical ImagingThe Ohio State University College of MedicineColumbusUSA
  4. 4.Department of Biomedical EngineeringCase Western Reserve UniversityClevelandUSA
  5. 5.Department of RadiologyCase Western Reserve UniversityClevelandUSA
  6. 6.National Foundation for Cancer Research Center for Molecular ImagingCase Western Reserve UniversityClevelandUSA
  7. 7.Department of Otolaryngology—Head and Neck Surgery and RadiologyStanford UniversityStanfordUSA
  8. 8.Ann and John Doerr Medical Director, Stanford Cancer CenterStanfordUSA

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