Characterization of “γ-Eye”: a Low-Cost Benchtop Mouse-Sized Gamma Camera for Dynamic and Static Imaging Studies
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Several preclinical imaging systems are commercially available, but their purchase and maintenance costs make them unaffordable for the majority of small- and medium-sized groups. Taking into account the needs of average users, we developed “γ-eye”, a mouse-sized, benchtop γ-camera suitable for in vivo scintigraphic imaging.
The γ-eye is based on two position-sensitive photomultiplier tubes, coupled to a CsI(Na) pixelated scintillator and a low-energy lead collimator with parallel hexagonal holes.
The spatial resolution of the system is 2 mm at 0 mm. The energy resolution is 26 % at 140 keV and the maximum recorded sensitivity 210 cps/MBq. The system was evaluated in a proof-of-concept animal study, using three different clinical Tc-99m-labeled radiopharmaceuticals. Phantom and animal studies demonstrate its ability to provide semiquantitative results even for short scans.
Systems’ performance, dimensions, and cost make γ-eye a unique solution for efficient whole-body mouse nuclear imaging.
Key wordsSingle photon emission Scintigraphic small animal imaging Position sensitive photomultiplier tube Performance evaluation
Compliance with Ethical Standards
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
Human and Animal Rights
All applicable institutional and/or national guidelines for the care and use of animals were followed.
Conflict of Interest
The technology similar to the “γ-eye” presented in this manuscript will be commercialized in the near future by BET Solutions, Athens, Greece. At this point, γ-eye system is in prototype version. Eleftherios Fysikopoulos and Konstantinos Mikropoulos are currently coworkers of BET Solutions, George Loudos is consultant for BET Solutions, and Maria Georgiou is a general partner of BET Solutions.
- 9.Zaidi H (2014) Molecular imaging of small animals: instrumentation and applications. SpringerGoogle Scholar
- 12.Meikle SR, Kench P, Kassiou M, Banati RB (2005) Small animal SPECT and its place in the matrix of molecular imaging technologies. Phys Med Biol 50:R45.5Google Scholar
- 17.Miller BW, Barber HB, Barrett HH, et al (2012) Progress in BazookaSPECT: high-resolution, dynamic scintigraphy with large-area imagers. Proc SPIE-- Int Soc Opt Eng.Google Scholar
- 18.Metaxa A-F, Efthimiadou EK, Boukos N et al (2014) Hollow microspheres based on—folic acid modified—hydroxypropyl cellulose and synthetic multi-responsive bio-copolymer for targeted cancer therapy: controlled release of daunorubicin, in vitro and in vivo studies. J Colloid Interface Sci 435:171–181CrossRefPubMedGoogle Scholar
- 23.Popov V (2004) Matrix output device readout system, US6747263B1.Google Scholar
- 28.Knoll GF (2010) Radiation detection and measurement. WileyGoogle Scholar
- 32.Georgiou M, Loudos G, Stratos D et al (2012) Optimization of a gamma imaging probe for axillary sentinel lymph mapping. J Instrum 7:P09010Google Scholar
- 38.Banerjee SR, Pomper MG (2013) Clinical applications of gallium-68. Appl Radiat Isot Data Instrum Methods Use Agric Ind Med 0:2–13Google Scholar
- 40.Pizzonia J, Holmberg J, Orton S et al (2012) Multimodality animal rotation imaging system (Mars) for in vivo detection of intraperitoneal tumors. Am J Reprod Immunol N Y N 1989 67:84–90Google Scholar