Deep Brain Stimulation of the Prelimbic Medial Prefrontal Cortex: Quantification of the Effect on Glucose Metabolism in the Rat Brain Using [18 F]FDG MicroPET
- 461 Downloads
Prefrontal cortex (PFC) deep brain stimulation (DBS) has been proposed as a therapy for addiction and depression. This study investigates changes in rat cerebral glucose metabolism induced by different DBS frequencies using μPET.
One hour DBS of the prelimbic area (PL) of the medial PFC (mPFC) (60 Hz, 130 Hz or sham) in rats (n = 9) was followed by 2-deoxy-2-[18 F] fluoro-d-glucose ([18 F]FDG) μPET.
Sixty Hz DBS elicited significant hypermetabolism in the ipsilateral PL ([18 F]FDG uptake +5.2 ± 2.3 %, p < 0.05). At 130 Hz, hypometabolism was induced in the ipsilateral PL (−2.5 ± 2.6 %, non-significant). Statistical parametric mapping revealed hypo and hypermetabolism clusters for both 60 and 130 Hz versus sham and show a certain state of alertness (increased activity in sensory and motor-related regions) mainly for 60 Hz.
This study suggests the potential of 60 Hz PL mPFC DBS for the treatment of disorders associated with prefrontal hypofunction.
Key wordsDorsolateral prefrontal cortex Medial prefrontal cortex Deep brain stimulation [18 F]FDG microPET Addiction Depression
This work was funded by Antwerp University, Belgium through a Ph.D. grant for J. Parthoens, a postdoctoral position for J. Verhaeghe, an associate professor position for S. Staelens and a full professor position for S. Stroobants. S. Stroobants is also supported by Antwerp University Hospital, Belgium through a departmental position. Hardware and experimental costs are supported by an IOF PoC grant (45/FA020000/27/5823) of Antwerp University. Both funding sources had no further role in the study design or in the collection, analysis, and interpretation of the data.
Conflict of Interest
The authors report no conflicts of interest.
- 12.Pelloux Y, Baunez C (2013) Deep brain stimulation for addiction: why the subthalamic nucleus should be favored. Curr. Opin, NeurobiolGoogle Scholar
- 20.Montgomery EB (2010) Deep brain stimulation programming: principles and practice. Press, Oxford UniversityGoogle Scholar
- 33.Parthoens J, Wyckhuys T, Stroobants S, Staelens S (2014) Small animal repetitive transcranial magnetic stimulation combined with [18 F]-FDG microPET to quantify the effect on glucose metabolism in the rat brain. submitted to Mol Imaging BiolGoogle Scholar
- 34.Paxinos G, Watson C (2007) The rat brain in stereotaxic coordinates. Press, AcademicGoogle Scholar