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[68Ga]-Albumin-PET in the Monitoring of Left Ventricular Function in Murine Models of Ischemic and Dilated Cardiomyopathy: Comparison with Cardiac MRI

Abstract

Purpose

The purpose of this study is to evaluate left ventricular functional parameters in healthy mice and in different murine models of cardiomyopathy with the novel blood pool (BP) positron emission tomography (PET) tracer [68Ga]-albumin.

Procedures

ECG-gated microPET examinations were obtained in healthy mice, and mice with dilative (DCM) and ischemic cardiomyopathy (ICM) using the novel BP tracer [68Ga]-albumin (AlbBP), as well as [18F]-FDG microPET. Cine-magnetic resonance imaging (MRI) examination performed on a clinical 1.5-T MRI provided the reference standard measurements.

Results

When considering the combined group of healthy controls, DCM and ICM AlbBP-PET significantly overestimated the magnitudes of EDV (AlbBP, 181 ± 86 μl; cine-MRI, 125 ± 80 μl; P < 0.001) and ESV (AlbBP, 136 ± 92 μl; cine-MRI, 96 ± 77 μl; P < 0.001), whereas the EF (AlbBP, 31 ± 16 %; cine-MRI, 33 ± 21 %; P = 0.910) matched closely to cine-MRI results, as did findings with [18F]-FDG. High correlations were found between the measured cardiac parameters (EDV: R = 0.978, ESV: R = 0.989, and LVEF: R = 0.992).

Conclusions

Measuring left ventricular function in mice with [68Ga]-albumin BP PET is feasible and showed a high correlation compared to cine-MRI, which was used as a reference standard.

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Acknowledgements

Financial support was provided by the Fritz-Bender-Stiftung and the Else Kröner-Fresenius-Stiftung.

Disclosures

None.

Author information

Correspondence to Marcus Hacker.

Additional information

Andrei Todica and Stefan Brunner contributed equally to this work.

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Todica, A., Brunner, S., Böning, G. et al. [68Ga]-Albumin-PET in the Monitoring of Left Ventricular Function in Murine Models of Ischemic and Dilated Cardiomyopathy: Comparison with Cardiac MRI. Mol Imaging Biol 15, 441–449 (2013). https://doi.org/10.1007/s11307-013-0618-y

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Key words

  • Cardiomyopathy
  • Ejection fraction
  • Positron emission tomography
  • Albumin
  • Magnetic resonance imaging