Functionalized Magnetonanoparticles in Visualization of Intracranial Tumors on MRI
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The development of nonradioactive and targeted magnetonanoparticles (MNP) capable of crossing the blood–brain barrier (BBB) and of concentrating in and enhancing the contrast of intracranial tumors on magnetic resonance imaging (MRI).
Nonradioactive 2-deoxy-d-glucose (2DG) was covalently attached to magnetonanoparticles composed of iron oxide and dextran and prepared for intravenous (tail) injection in the naïve rats and mouse models of glioma. MR images were acquired at 3 and 7 T.
2DG-MNP increased tumor visibility and improved delineation of tumor margins. Histopathology confirmed that 2DG-MNP crossed the BBB and accumulated within brain parenchyma.
Nonradioactive 2DG-MNP can cross an intact BBB on and improve visualization of tumor and tumor margins on MRI.
Key wordsMagnetonanoparticles Targeted Glioma 2-Deoxyglucose MRI Contrast
The authors are greatly indebted to Dr. Gevorg Karapetian and Dr. Ira Harutyunyan for their invaluable help and input with acquisition of the MR images. The authors are also indebted to Dr. Leonard Rome of UCLA School of Medicine Dean’s Office for his foresight and support of this project. This Work was supported by generous grants from Stein/Oppenheimer Award, Jane and Terry Semel Institute for Neuroscience and Human Behavior Chairman’s, Opportunity funds, and Weil Fund, as well as, Office of the Dean, David Geffen School of Medicine, Davis Fund.
Conflict of Interest
The technology used in these studies is owned by the University of California, and Dr. Akhtari has received royalty payments from the University of California during the past 3 years. None of the other authors has any conflict of interest. We confirm that we have read the Journal’s position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.
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