Evaluation of the Olfactory Nerve Transport Function by SPECT-MRI Fusion Image with Nasal Thallium-201 Administration
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The aim of this study was to visualize the human olfactory transport pathway to the brain by performing imaging after nasal thallium-201 (201Tl) administration.
Healthy volunteers were enrolled in this study after giving informed consent (five males, 35–51 years old). The subjects were nasally administered 201TlCl into either the olfactory cleft. Twenty-four hours later, uptake of 201Tl was detected by a single photon emission computed tomography (SPECT)/X-ray computed tomography hybrid system. For each subject, an MRI image was obtained and merged with the SPECT image.
The peak of the 201Tl uptake entered into the olfactory bulb in the anterior skull base through the cribriform lamina 24 h after nasal administration of 201Tl. No participant had olfactory disturbance after treatment.
Nasal 201Tl administration was safely used to assess the direct pathway to the brain via the nose in healthy volunteers with normal olfactory threshold.
Key WordsOlfactory transport Thallium-201 Nasal administration SPECT-MRI Mutual information method
This study was funded in part by Grant-in-Aid for Scientic Research from the Ministry of Education, Science and Culture of Japan (C21592174 to H.S.).
Conflict of interest statement
The authors declare that they have no competing financial interests.