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Molecular Imaging and Biology

, Volume 13, Issue 6, pp 1262–1266 | Cite as

Evaluation of the Olfactory Nerve Transport Function by SPECT-MRI Fusion Image with Nasal Thallium-201 Administration

  • Hideaki ShigaEmail author
  • Junichi Taki
  • Masato Yamada
  • Kohshin Washiyama
  • Ryohei Amano
  • Yukihiro Matsuura
  • Osamu Matsui
  • Shinji Tatsutomi
  • Sayaka Yagi
  • Asuka Tsuchida
  • Tomokazu Yoshizaki
  • Mitsuru Furukawa
  • Seigo Kinuya
  • Takaki Miwa
Research Article

Abstract

Purpose

The aim of this study was to visualize the human olfactory transport pathway to the brain by performing imaging after nasal thallium-201 (201Tl) administration.

Procedures

Healthy volunteers were enrolled in this study after giving informed consent (five males, 35–51 years old). The subjects were nasally administered 201TlCl into either the olfactory cleft. Twenty-four hours later, uptake of 201Tl was detected by a single photon emission computed tomography (SPECT)/X-ray computed tomography hybrid system. For each subject, an MRI image was obtained and merged with the SPECT image.

Results

The peak of the 201Tl uptake entered into the olfactory bulb in the anterior skull base through the cribriform lamina 24 h after nasal administration of 201Tl. No participant had olfactory disturbance after treatment.

Conclusions

Nasal 201Tl administration was safely used to assess the direct pathway to the brain via the nose in healthy volunteers with normal olfactory threshold.

Key Words

Olfactory transport Thallium-201 Nasal administration SPECT-MRI Mutual information method 

Notes

Acknowledgments

This study was funded in part by Grant-in-Aid for Scientic Research from the Ministry of Education, Science and Culture of Japan (C21592174 to H.S.).

Conflict of interest statement

The authors declare that they have no competing financial interests.

Supplementary material

11307_2010_461_MOESM1_ESM.doc (514 kb)
ESM 1 (DOC 513 kb)

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Copyright information

© Academy of Molecular Imaging and Society for Molecular Imaging 2010

Authors and Affiliations

  • Hideaki Shiga
    • 1
    Email author
  • Junichi Taki
    • 2
  • Masato Yamada
    • 3
  • Kohshin Washiyama
    • 4
  • Ryohei Amano
    • 4
  • Yukihiro Matsuura
    • 5
  • Osamu Matsui
    • 5
    • 6
  • Shinji Tatsutomi
    • 7
  • Sayaka Yagi
    • 7
  • Asuka Tsuchida
    • 7
  • Tomokazu Yoshizaki
    • 7
  • Mitsuru Furukawa
    • 8
  • Seigo Kinuya
    • 2
    • 3
  • Takaki Miwa
    • 1
  1. 1.Department of Otorhinolaryngology—Head and Neck SurgeryKanazawa Medical UniversityIshikawaJapan
  2. 2.Department of Biotracer Medicine, Graduate School of Medical ScienceKanazawa UniversityIshikawaJapan
  3. 3.Division of RadioisotopesKanazawa University HospitalIshikawaJapan
  4. 4.Department of Quantum Medical Technology, Graduate School of Medical ScienceKanazawa UniversityIshikawaJapan
  5. 5.Division of RadiologyKanazawa University HospitalIshikawaJapan
  6. 6.Department of Radiology, Graduate School of Medical ScienceKanazawa UniversityIshikawaJapan
  7. 7.Department of Otorhinolaryngology—Head and Neck Surgery, Graduate School of Medical ScienceKanazawa UniversityIshikawaJapan
  8. 8.Kanazawa UniversityIshikawaJapan

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